Progress in Molecular Nanoarchitectonics and Materials Nanoarchitectonics

Abstract

Although various synthetic methodologies including organic synthesis, polymer chemistry, and materials science are the main contributors to the production of functional materials, the importance of regulation of nanoscale structures for better performance has become clear with recent science and technology developments. Therefore, a new research paradigm to produce functional material systems from nanoscale units has to be created as an advancement of nanoscale science. This task is assigned to an emerging concept, nanoarchitectonics, which aims to produce functional materials and functional structures from nanoscale unit components. This can be done through combining nanotechnology with the other research fields such as organic chemistry, supramolecular chemistry, materials science, and bio-related science. In this review article, the basic-level of nanoarchitectonics is first presented with atom/molecular-level structure formations and conversions from molecular units to functional materials. Then, two typical application-oriented nanoarchitectonics efforts in energy-oriented applications and bio-related applications are discussed. Finally, future directions of the molecular and materials nanoarchitectonics concepts for advancement of functional nanomaterials are briefly discussed.

Lipid Nanoparticle Technologies for Nucleic Acid Delivery: A Nanoarchitectonics Perspective

“…As evidenced by the previous section, the key to the success of LNPs as nucleic acid delivery systems lies in a solid understanding of the structure-function relationship. Clearly, the molecular structures define the resultant geometry of the lipid components, affect their interaction with the nucleic acids, and influence the overall morphology and physicochemical properties of the LNP (i.e., the concept of nanoarchitectonics [71] ), all of which in turn determine the behavior of LNPs in vivo, and ultimately the performance of the LNPs within the context of a nucleic acid delivery system. [72] While the design principles are built upon these correlations, they would not have been realized without proper and consistent control over the LNP fabrication process, which has allowed systematic studies to be conducted in a reproducible manner.…”

Weak Polyelectrolytes as Nanoarchitectonic Design Tools for Functional Materials: A Review of Recent Achievements

“…Functional materials with precisely controlled compositions and (nano)structures and predictable responses to stimuli are prime candidates to address a number of challenges in fields including biomaterials, vectorization, and energy storage and conversion [ 1 ]. The development of such “smart” materials relies largely on designing functional systems through the assembly of well-controlled nanoscale units.…”

Oligomer Sensor Nanoarchitectonics for “Turn-On” Fluorescence Detection of Cholesterol at the Nanomolar Level

“…Over the past decade, numerous researchers have sought to create functional systems composed of well-controlled nano-units [1,2]. This new concept, called nanoarchitectonics, has enabled the combination of nanotechnology with organic synthesis, materials science, biological and supramolecular approaches, resulting in nanosystems with well-defined structures and functions [3,4].…”