Progress in modifications and applications of fluorescent dye probe

Fei, Xuening; Gu, Yingchun

doi:10.1016/j.pnsc.2008.06.004

Cited by 111 publications

(50 citation statements)

References 29 publications

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“…Molecules of dyes can label compounds by a covalent bonding using an active group (-SH, -COOH, -NH 2 ) or might be inserted into the double-helix structure of DNA by affinity, as in the case of thiazole orange, oxazole yellow and their dimers [13,14]. Antibodies (their size is about 12 nm) endowed with fluorescent dyes (e.g., Alexa Fluor 488 λEm=525 nm and Texas Red λEm=609 nm) [15][16][17] were used in the development of a wide range of effective targeted therapies [18][19][20][21][22] but they create clustering artifacts due to limited antibody penetration, which have an impact on insufficient labeling density.…”

Section: Fluorescent Small Molecules As Cell-type-specific Imaging Prmentioning

confidence: 99%

Fluorescent Dyes Used in Polymer Carriers as Imaging Agents in Anticancer Therapy

Miksa¹

2016

Med chem (Los Angeles)

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This review highlights the role of fluorescent dyes as active "molecular photoswiches" focusing on the application in bioimaging and anticancer therapies in the field of therapeutic delivery. The author describes the development of prodrugs targeted to specific cell types and polymeric nanocarriers (capsules, micelles and silica nanoparticles) used as fluorescent probes which offer advantages in the integration of "smart" features of fluorescent dyes into synthetic materials. The incorporation of biologically responsive components that cleave upon changes in pH or light irradiation is fundamental to the successful design of such carriers with capabilities to load and release therapeutics specifically at a target site.

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Section: Fluorescent Small Molecules As Cell-type-specific Imaging Prmentioning

confidence: 99%

Fluorescent Dyes Used in Polymer Carriers as Imaging Agents in Anticancer Therapy

Miksa¹

2016

Med chem (Los Angeles)

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“…The factor was used to convert the diameters of individual particles to nm. A number of particles (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40) were selected for each sample and the size distribution was determined.…”

Section: Particle Size Measurementmentioning

confidence: 99%

“…However, these fluorophores have the tendency to photobleach quickly, which does not allow monitoring and bioimaging for extended time periods. Most fluorescent dyes are reported to be cytotoxic and are known to induce chemical changes to the biological structures under observation, limiting their use in-vitro and in-vivo [26]. Moreover, the degradability of SF in biological environment can lead to significant uncertainty in the fluorophore emission.…”

Section: Introductionmentioning

confidence: 99%

Doxorubicin loaded nanodiamond-silk spheres for fluorescence tracking and controlled drug release

Khalid

Mitropoulos

Marelli

et al. 2015

Biomed. Opt. Express

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Nanoparticle (NP) based technologies have proved to be considerably beneficial for advances in biomedicine especially in the areas of disease detection, drug delivery and bioimaging. Over the last few decades, NPs have garnered interest for their exemplary impacts on the detection, treatment, and prevention of cancer. The full potential of these technologies are yet to be employed for clinical use. The ongoing research and development in this field demands single multifunctional composite materials that can be employed simultaneously for drug delivery and biomedical imaging. In this manuscript, a unique combination of silk fibroin (SF) and nanodiamonds (NDs) in the form of nanospheres are fabricated and investigated. The spheres were loaded with the anthracyline Doxorubicin (DoX) and the drug release kinetics for these ND-SF-DoX (NDSX) spheres were studied. NDs provided the fluorescence modality for imaging while the degradable SF spheres stabilized and released the drug in a controlled manner. The emission and structural properties of the spheres were characterized during drug release. The degradability of SF and the subsequent release of DoX from the spheres were monitored through fluorescence of NDs inside the spheres. This research demonstrates the enormous potential of the ND-SF nanocomposite platforms for diagnostic and therapeutic purposes, which are both important for pharmaceutical research and clinical settings. "Nanodiamond-mediated drug delivery and imaging: challenges and opportunities," Expert Opin. Drug Deliv. 12(5), 735-749 (2015).

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“…Such materials could also be used as suitable matrices for the growth of stem cells. Moreover, during recent decades, the fluorescent conjugated polymers and their use as active components in organic light-emitting diodes, photoconductors, and sensors give the electrospinning technique farther attractiveness to be leader technology [15][16][17]. The electrospinning is applicable practically to every soluble or fusible polymer.…”

Section: Introductionmentioning

confidence: 99%

Application of Fluorescent Label in Polymer Nanofibers

Zárybnická

Bačovská

Nadvornikova

et al. 2017

Advances in Materials Science and Engineering

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The electrospinning of fluorescent probe polyamide 6 doped by 7H-benzimidazo[2,1-a]benzo [de]isoquinolin-7-on is presented as a model processing photoluminescent nanofibers. The presence of the fluorescent probe in the fiber layers was confirmed by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR); the surface nanofiber structure was described by high-resolution fluorescence microscope and scanning electron microscope images. The prepared nanofibers with the fluorescent label were further characterized by fluorescence spectroscopy, both in the solid phase and in the solution.

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Progress in modifications and applications of fluorescent dye probe

Cited by 111 publications

References 29 publications

Fluorescent Dyes Used in Polymer Carriers as Imaging Agents in Anticancer Therapy

Fluorescent Dyes Used in Polymer Carriers as Imaging Agents in Anticancer Therapy

Doxorubicin loaded nanodiamond-silk spheres for fluorescence tracking and controlled drug release

Application of Fluorescent Label in Polymer Nanofibers

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