Progress in Gelatin as Biomaterial for Tissue Engineering

Lukin, Izeia; Erezuma, Itsasne; Maeso, Lidia; Zárate, Jon; Desimone, Martín Federico; Al‐Tel, Taleb H.; Dolatshahi‐Pirouz, Alireza; Orive, Gorka

doi:10.3390/pharmaceutics14061177

Cited by 107 publications

(79 citation statements)

References 117 publications

(194 reference statements)

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“…As a natural extracellular-derived proteinaceous material, gelatin has been widely studied and applied in various biomedical fields, due to its implantability, biocompatibility and degradable properties ( Stevens et al, 2002 ). However, gelatin itself as well as GelMA does not possess a biological infiltration capacity after implantation in the defect area, which limits its repair efficacy of bone defects ( Lukin et al, 2022 ). Therefore, enhancing the bio-infiltration function of gelatin through surface modifications is expected to improve the biocompatibility and regeneration efficacy of implant materials.…”

Section: Introductionmentioning

confidence: 99%

Superwettable and injectable GelMA-MSC microspheres promote cartilage repair in temporomandibular joints

Yang

Huang²,

Zheng³

et al. 2022

Front. Bioeng. Biotechnol.

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Temporomandibular disorders (TMD) can be treated by promoting cartilage regeneration with biomaterials. However, there are deficiencies in the infiltration function of bone filler biological materials. In this study, stems cells were loaded onto gelatin methacryloyl (GelMA) hydrogel microspheres endowed with superwettable properties and TGF-β sustained-release function, which can quickly infiltrate the irregular surface of the temporomandibular joint (TMJ) bone defect area and accelerate cartilage healing. First, to improve cell adhesion and spreading function, the BMSCs-coated GelMA microspheres were endowed with superwetting property. At the same time, the swelling adsorption characteristics of gelatin microspheres could be used to load recombinant TGF-β within the microspheres, which could in turn promote the chondrogenic differentiation of multi-potent bone marrow mesenchymal stem cells. The SEM imaging demonstrated that BMSCs-coated GelMA microsphere has superwettable and superhydrophilic property, which enabled rapid adaptation to the bone defect surface morphology, which is conducive to tissue repair. Furthermore, the cartilage defect model showed that rBMSCs-coated GelMA microspheres promote temporomandibular joint arthritis repair. In conclusion, our study established that BMSC-coated GelMA microspheres endowed with superwetting properties, can colonize the bone defect repair site better with sustained release of growth factors, thus providing an innovative strategy for promoting cartilage regeneration.

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Section: Introductionmentioning

confidence: 99%

Superwettable and injectable GelMA-MSC microspheres promote cartilage repair in temporomandibular joints

Yang

Huang²,

Zheng³

et al. 2022

Front. Bioeng. Biotechnol.

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“…Gelatin is biocompatible and easy to use. It presents some of the advantages of collagen but without having exactly the same properties, especially concerning mechanical properties [ 16 ]. Fibrin is the main constituent of blood clots and forms a glue that is widely used as an efficient biological sealant in vivo [ 17 ] or to study angiogenesis in vitro in a very simplistic way [ 18 , 19 ].…”

Section: Tissue Engineering In Gynecologymentioning

confidence: 99%

Tissue Engineering in Gynecology

Brownell

Chabaud

Bolduc

2022

IJMS

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Female gynecological organ dysfunction can cause infertility and psychological distress, decreasing the quality of life of affected women. Incidence is constantly increasing due to growing rates of cancer and increase of childbearing age in the developed world. Current treatments are often unable to restore organ function, and occasionally are the cause of female infertility. Alternative treatment options are currently being developed in order to face the inadequacy of current practices. In this review, pathologies and current treatments of gynecological organs (ovaries, uterus, and vagina) are described. State-of-the-art of tissue engineering alternatives to common practices are evaluated with a focus on in vivo models. Tissue engineering is an ever-expanding field, integrating various domains of modern science to create sophisticated tissue substitutes in the hope of repairing or replacing dysfunctional organs using autologous cells. Its application to gynecology has the potential of restoring female fertility and sexual wellbeing.

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“…Gelatin is biocompatible and easy to use. It presents some of the advantages of collagen but without having exactly the same properties, especially concerning the mechanical properties [16]. Fibrin is the main constituent of blood clots and forms a glue which is widely used as an efficient biological sealant in vivo [17] or to study angiogenesis in vitro in a very simplistic way [18], [19].…”

Section: Biomaterialsmentioning

confidence: 99%

Tissue Engineering in Gynecology

Brownell¹,

Chabaud²,

Bolduc³

2022

Preprint

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Female gynecological organ dysfunction can cause infertility and psychological distress, decreasing quality of life of affected women. Incidence is constantly increasing due to growing rates of cancer and delaying of childbearing age in the developed world. Current treatments are often unable to restore organ function, and occasionally are the cause for female infertility. Alternative treatment options are currently being developed in order to face the inadequacy of current practices. In this review, pathologies and current treatments of gynecological organs (ovaries, uterus, and vagina) will be described. The state-of-the-art of tissue engineering alternatives to common practices are evaluated with a focus on in vivo models. Tissue engineering is an ever-expanding field, integrating various domains of modern science to create sophisticated tissue substitutes in the hopes of repairing or replacing dysfunctional organs using autologous cells. Application to gynecology has the potential of restoring female fertility and sexual wellbeing.

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Progress in Gelatin as Biomaterial for Tissue Engineering

Cited by 107 publications

References 117 publications

Superwettable and injectable GelMA-MSC microspheres promote cartilage repair in temporomandibular joints

Superwettable and injectable GelMA-MSC microspheres promote cartilage repair in temporomandibular joints

Tissue Engineering in Gynecology

Tissue Engineering in Gynecology

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