Progress in Colloid Delivery Systems for Protection and Delivery of Phenolic Bioactive Compounds: Two Study Cases—Hydroxytyrosol and Curcumin

Abstract

Insufficient intake of beneficial food components into the human body is a major issue for many people. Among the strategies proposed to overcome this complication, colloid systems have been proven to offer successful solutions in many cases. The scientific community agrees that the production of colloid delivery systems is a good way to adequately protect and deliver nutritional components. In this review, we present the recent advances on bioactive phenolic compounds delivery mediated by colloid systems. As we are aware that this field is constantly evolving, we have focused our attention on the progress made in recent years in this specific field. To achieve this goal, structural and dynamic aspects of different colloid delivery systems, and the various interactions with two bioactive constituents, are presented and discussed. The choice of the appropriate delivery system for a given molecule depends on whether the drug is incorporated in an aqueous or hydrophobic environment. With this in mind, the aim of this evaluation was focused on two case studies, one representative of hydrophobic phenolic compounds and the other of hydrophilic ones. In particular, hydroxytyrosol was selected as a bioactive phenol with a hydrophilic character, while curcumin was selected as typical representative hydrophobic molecules.

Exploring the anti-inflammatory activities, mechanism of action and prospective drug delivery systems of tocotrienol to target neurodegenerative diseases

“…Even though curcumin has the least oral toxicity and highest bioactivities compared to its curcuminoid counterparts, its hydrophobic nature, and poor water solubility results in reduced oral bioavailability. 85 The curcumin-loaded nanoliposomes were found to have improved stability, physicochemical properties, controlled drug release properties, and equivalent cellular antioxidant activity (CAA). But the curcumin entrapped in nanoliposomes had lower cellular uptake than the free curcumin.…”

Exploring the Use of Hydroxytyrosol and Some of Its Esters in Food-Grade Nanoemulsions: Establishing Connection between Structure and Efficiency

“…Several strategies were proposed to incorporate it in biocompatible systems that improve its bioavailability profile in order to take full advantage of its health properties. Much attention has been paid to lipid-based formulations as microemulsions and nanoemulsions [27]. However, its bioavailability was not always optimal, showing problems for reaching its target system at sufficient concentrations [25].…”

Effect of α-Amylase on the Structure of Chia Seed Mucilage

“…Hydrocolloids are suspensions of hydrophilic polymers capable of forming viscous solutions or assembling hydrogels when dispersed in water. In addition to their applications in the biomedical field [ 1 , 7 , 8 ], these materials have also attracted the interest of the food industry because of their ability to alter the rheological behavior of ingredients, particularly viscosity and texture, which are essential for food appreciation [ 9 , 10 , 11 , 12 ]. In such systems, the specific molecular interactions between the polymers that comprise them play a fundamental role [ 11 , 13 ].…”

“…In addition to their applications in the biomedical field [ 1 , 7 , 8 ], these materials have also attracted the interest of the food industry because of their ability to alter the rheological behavior of ingredients, particularly viscosity and texture, which are essential for food appreciation [ 9 , 10 , 11 , 12 ]. In such systems, the specific molecular interactions between the polymers that comprise them play a fundamental role [ 11 , 13 ]. Therefore, hydrocolloids are valuable food additives used as thickeners, gelling agents, or emulsifiers, to name just a few of their many applications [ 14 ].…”