Programming for responsiveness to environmental antigens that trigger allergic respiratory disease in adulthood is initiated during the perinatal period.

Holt, Patrick G.

doi:10.1289/ehp.98106795

Cited by 47 publications

(31 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The higher prevalence of AD in the first life of age is caused by the failure of immune deviation that should normally select for Th1 cell in immune response skewed to Th2 in post nataly in atopic children. 14 Atopy is more prevalence in male than female before puberty. There is a reversal of this sex ratio during puberty with girls having more asma and atopy throughout there productive years.…”

Section: Discussionmentioning

confidence: 99%

Serum 25-hydroxyvitamin-D level and atopic dermatitis severity in children

Munawwarah

Evalina

Sofyani

2018

View full text Add to dashboard Cite

Background Vitamin D plays an important role in the immune system. It inhibits B-lymphocyte proliferation and modulates the humoral response to suppress IgE production. Studies on the relationship between serum 25-hydroxyvitamin-D level and the severity of atopic dermatitis in several countries have had varying results. Objective To assess for a possible correlation between serum 25-hydroxyvitamin-D level and atopic dermatitis severity in children. Methods A cross-sectional study was conducted in 26 children with atopic dermatitis from September to December 2015. We evaluated the severity of disease using the Scoring of Atopic Dermatitis

show abstract

Section: Discussionmentioning

confidence: 99%

Serum 25-hydroxyvitamin-D level and atopic dermatitis severity in children

Munawwarah

Evalina

Sofyani

2018

View full text Add to dashboard Cite

show abstract

“…Beside a genetic propensity and the influence of environmental allergens in countries with a western lifestyle, research has focused on basic mechanisms governing allergic reaction. For a disease beginning mostly early in infancy, it appears necessary to first understand the cellular and molecular mechanisms underlying the induction and expression of allergic reactions (24). A line of evidence now supports the hypothesis that fetal T cells are exposed during gestation to maternally derived allergens.…”

Section: Discussionmentioning

confidence: 99%

Direct Evidence for Transplacental Allergen Transfer

et al. 2000

View full text Add to dashboard Cite

Allergies are increasing, and despite deeper insights into the immunologic basis of these diseases, preventive measures are not yet efficient. As the induction of allergic diseases is often triggered in early childhood, perinatal or prenatal preventive strategies would be beneficial. We investigated the transfer of inhalant and nutritive allergens across the human placenta. For this purpose, the maternal side of a placental cotyledon was perfused in vitro with an allergen-containing medium, and a specific ELISA was used to detect the allergens on the fetal side. Both allergens evaluated, birch pollen major allergen Bet v1 and the milk allergen beta-lactoglobulin, could be shown to cross the placenta. The nutritive allergen beta-lactoglobulin was not only transferred across the placenta in all eight experiments, but was also detectable within the first minutes of perfusion. The peak allergen concentration on the fetal side could be increased by addition of human immunoglobulin. For the inhalant allergen Bet v1, transfer was observed in two of 10 placental experiments, and only if human immunoglobulin was added. A pulsatility wave with a frequency of 30 -35 min suggested an active transfer mechanism. We conclude that allergens are actively and selectively transferred across the placenta. Therefore, controlled maternal allergen exposure might offer new ways to induce tolerance to specific allergens in the fetus. There is increasing evidence that the prevalence of allergic diseases is currently rising at an unprecedented rate (1-3). It is also becoming clear that this rise is largely restricted to developed countries, a phenomenon that is widely believed to be linked to a western lifestyle (4). Eliciting agents, preferentially environmental allergens, are predominantly found in indoor environments. Recently, concern has been raised as to any priming effects of exposure to environmental influences even before birth; that is, through the placenta.Allergen-specific T cell proliferation in cord blood cells has been demonstrated by many groups and for many different allergens (5-15). Inhalant and nutritive allergens in the form of crude extracts [birch pollen (5, 7), house dust mite (8 -10, 15), timothy grass pollen (5, 7), cat fur (5, 7), BLG (5, 7, 13, 16), alpha-casein (13), beta-casein (13), kappa-casein (13), BSA (5-7, 13), and ovalbumin (5, 7, 11, 15, 16)] and in the form of recombinant allergens [Lol p1 (9), Der p1 (9), Bet v1 (14), and Phl p1 (14)] has been studied. A line of evidence now supports the hypothesis that fetal T cells are exposed during gestation to maternally derived allergens. These allergens may be ingested or inhaled by the mother (14). The time at which maternofetal allergen exposure takes place in the course of a pregnancy is less clear. The current knowledge suggests early times during gestation, presumably around wk 20 of gestation (5, 14), Szépfalusi et al. unpublished experiments).The occurrence of prenatal T cell priming and its possible impact on later allergic status has been the subject...

show abstract

“…Assuming a "sensitization window" during the first few months of life [25], one would expect that children who were born after German reunification, when tremendous changes in living and social conditions began would be more affected than children born before. In accordance with this assumption, studies did not find any increase of prevalence of allergic sensitization in children born prior to the reunification [2,21].…”

Section: Possible Reasons For the Increased Prevalence Of Atopic Disementioning

confidence: 99%

Trends in prevalence of atopic diseases and allergic sensitization in children in Eastern Germany

Heinrich¹,

Hoelscher²,

Frye³

et al. 2002

Eur Respir J

122

View full text Add to dashboard Cite

Trends in prevalence of atopic diseases and allergic sensitization in children from Eastern Germany during the 1990s were analysed.The study consisted of three regional cross-sectional surveys of a total of 7,632 children (aged 5-14 yrs) in 1992-1993, 1995-1996, and 1998-1999. Information was gathered on atopic diseases and potential predictors by a parental questionnaire. Allergic sensitization for birch, grass, mite, cat, and cladosporium were assessed by radioallergosorbent test (RAST).After adjustment for age, sex and the study area of the participants, prevalence increased between the first and third survey for hay fever, for asthma and for atopic eczema. The adjusted prevalence of allergic sensitization (RASTw0.35 kU?L -1 ) showed a decrease, whereas the prevalence of strong sensitization (RAST o17.5 kU?L -1 ) increased significantly, specifically in cohorts born after 1989. Further adjustment for possible determinants of these atopic diseases did not change the trend estimates.A clear increase in the prevalence of atopic diseases, with the exception of hay fever, was observed as well as a shift towards a stronger allergic sensitization, which might affect the onset of clinical manifestations of atopic diseases.Differences in the epidemiology of respiratory symptoms, illnesses and allergies between populations living in the former East Germany and those living in the former West Germany have been reported. Among East German children, lower prevalence rates of asthma, and positive skin-prick tests were observed compared to West German children in the early 1990s [1][2][3][4][5]. Similarly, among East German adults, lower specific immunoglobulin (Ig) E levels and lower prevalence rates of asthma, wheezing, positive methacholine-challenge tests, allergic rhinitis, and positive skin-prick tests have been reported compared to those of West German adults [6,7].

show abstract

Programming for responsiveness to environmental antigens that trigger allergic respiratory disease in adulthood is initiated during the perinatal period.

Cited by 47 publications

References 61 publications

Serum 25-hydroxyvitamin-D level and atopic dermatitis severity in children

Serum 25-hydroxyvitamin-D level and atopic dermatitis severity in children

Direct Evidence for Transplacental Allergen Transfer

Trends in prevalence of atopic diseases and allergic sensitization in children in Eastern Germany

Contact Info

Product

Resources

About