Programmed cell death evidence in wheat (Triticum aestivumL.) roots induced by aluminum oxide (Al2O3) nanoparticles

Yanık, Fatma; Aytürk, Özlem; Vardar, Filiz

doi:10.1080/00087114.2017.1286126

Cited by 18 publications

(7 citation statements)

References 51 publications

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“…Interestingly, Al-induced PCD in peanut ( Arachis hypogaea ) root tip cells is activated by a number of caspase-like proteases, but the crucial enzyme in this process is a caspase-3-like enzyme, with the highest activity observed after Al addition [ 117 ]. The same finding was described in Triticum aestivum root tip cells, where caspase-3-, caspase-8-, and caspase-9-like activities were detected after the addition of Al 2 O 3 [ 120 ]. Metacaspase AhMC1 induces PCD in peanut root tip cells after an Al treatment, and its overexpression reduces the resistance of peanuts to this metalloid [ 118 ].…”

Section: Regulation and Execution Processes Engaging Plant Proteassupporting

confidence: 78%

Insights into Plant Programmed Cell Death Induced by Heavy Metals—Discovering a Terra Incognita

Sychta

Słomka

Kuta

2021

Cells

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Programmed cell death (PCD) is a process that plays a fundamental role in plant development and responses to biotic and abiotic stresses. Knowledge of plant PCD mechanisms is still very scarce and is incomparable to the large number of studies on PCD mechanisms in animals. Quick and accurate assays, e.g., the TUNEL assay, comet assay, and analysis of caspase-like enzyme activity, enable the differentiation of PCD from necrosis. Two main types of plant PCD, developmental (dPCD) regulated by internal factors, and environmental (ePCD) induced by external stimuli, are distinguished based on the differences in the expression of the conserved PCD-inducing genes. Abiotic stress factors, including heavy metals, induce necrosis or ePCD. Heavy metals induce PCD by triggering oxidative stress via reactive oxygen species (ROS) overproduction. ROS that are mainly produced by mitochondria modulate phytotoxicity mechanisms induced by heavy metals. Complex crosstalk between ROS, hormones (ethylene), nitric oxide (NO), and calcium ions evokes PCD, with proteases with caspase-like activity executing PCD in plant cells exposed to heavy metals. This pathway leads to very similar cytological hallmarks of heavy metal induced PCD to PCD induced by other abiotic factors. The forms, hallmarks, mechanisms, and genetic regulation of plant ePCD induced by abiotic stress are reviewed here in detail, with an emphasis on plant cell culture as a suitable model for PCD studies. The similarities and differences between plant and animal PCD are also discussed.

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Section: Regulation and Execution Processes Engaging Plant Proteassupporting

confidence: 78%

Insights into Plant Programmed Cell Death Induced by Heavy Metals—Discovering a Terra Incognita

Sychta

Słomka

Kuta

2021

Cells

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“…That may cause stabilizing activity of mitotic cyclin dependent kinases (M-CdK) all time and preventing cells to exit from mitosis (Tawab et al 2014). Drugs causing alterations in microtubules prevent alignment of the daughter chromosomes and consequently lead to stop of mitosis at metaphase and anaphase, which can be finally followed by apoptosis (Safarzadeh et al 2014;Yanık et al 2017;Huang et al 2019).…”

Section: Discussionmentioning

confidence: 99%

Assessment of antimitotic and programmed cell death stimulation potentials of Galium sinaicum (Delile ex Decne) Boiss. at cellular level

Sobieh

2021

Caryologia

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Galium sinaicum is a wild medicinal plant in saint Catherine, Egypt. To distinguish apoptotic effect of G. sinaicum ethanol extract (GsEE), we examined the role of GsEE in inducing programmed cell death (PCD) of Allium cepa root meristematic cell (AcR). Cells was subjected to GsEE in definite concentrations (0.1,0.3, 0.5%) and duration (6, 12h), then PCD induction was assessed. Application of GsEE arrested the mitotic division of AcR with metaphase accumulation. Electron microscopy analysis demonstrated ultrastructural alterations of organelles verifying PCD hallmarks. Protein electrophoresis analysis of AcR revealed a change in protein profile of Allium cepa root, also quantitative analysis showed significant increase in nuclease activity enzymes that stimulated DNA laddering fragmentation. Additionally, cell proliferation of MCF-7 and BHK21 was arrested by GsEE. Apoptotic effect of G. sinaicum may be attributed to the presence of potent phenolic compounds such as querectin and rutin as established by HPLC phenolic fingerprint analysis.

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“…Despite the fact that plants have the ability to tolerate certain concentrations of these metals, when a certain level is exceeded, it causes toxicity, leading to the generation of ROS [71]. Although plant extracts have been reported to prevent heavy-metal-induced stress [72], only cysteine proteases, such as caspases and vacuolar processing enzymes, have been shown to be involved in this process [73][74][75].…”

Section: Response To Abiotic Stressmentioning

confidence: 99%

Defense and Offense Strategies: The Role of Aspartic Proteases in Plant–Pathogen Interactions

Figueiredo

Santos

Figueiredo

2021

Biology

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Plant aspartic proteases (APs; E.C.3.4.23) are a group of proteolytic enzymes widely distributed among different species characterized by the conserved sequence Asp-Gly-Thr at the active site. With a broad spectrum of biological roles, plant APs are suggested to undergo functional specialization and to be crucial in developmental processes, such as in both biotic and abiotic stress responses. Over the last decade, an increasing number of publications highlighted the APs’ involvement in plant defense responses against a diversity of stresses. In contrast, few studies regarding pathogen-secreted APs and AP inhibitors have been published so far. In this review, we provide a comprehensive picture of aspartic proteases from plant and pathogenic origins, focusing on their relevance and participation in defense and offense strategies in plant–pathogen interactions.

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Programmed cell death evidence in wheat (Triticum aestivumL.) roots induced by aluminum oxide (Al₂O₃) nanoparticles

Cited by 18 publications

References 51 publications

Insights into Plant Programmed Cell Death Induced by Heavy Metals—Discovering a Terra Incognita

Insights into Plant Programmed Cell Death Induced by Heavy Metals—Discovering a Terra Incognita

Assessment of antimitotic and programmed cell death stimulation potentials of Galium sinaicum (Delile ex Decne) Boiss. at cellular level

Defense and Offense Strategies: The Role of Aspartic Proteases in Plant–Pathogen Interactions

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