Programme national de surveillance du mésothéliome pleural (PNSM) : vingt années de surveillance des cas, de leurs expositions et de leur reconnaissance médico-sociale (1998-2017)

Ilg, Anabelle Gilg Soit; Ducamp, Stéphane; Grange, Dorothée; Audignon, Sabyne; Gramond, Céline; Chamming’s, Soizick; Stang, Nolwenn Le; Frenay, C.; Galateau-Sallé, Françoise; Pairon, Jean‐Claude; Astoul, Philippe; Brochard, Patrick; Chérié-Challine, L.

doi:10.1016/j.admp.2020.03.637

Cited by 2 publications

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“…To minimize the risk of bias and increase the quality of this review, only studies related to MPM, the only disease known to date to be monofactorial after exposure to asbestos [5,8,11,12], were included. Data were always reviewed by two reviewers, and a third reviewer read studies to resolve disagreements.…”

Section: Risk Of Bias (Quality) Assessmentmentioning

confidence: 99%

“…In regard to mortality from malignant pleural tumours, it was predicted that peak mortality would be reached in the early 2000 [13] as well as the incidence, considering the poor prognosis of this disease [12]. However, with the still current production and consumption [16,17] and the unreported cases occurring in developing countries [55], problem that lobbyists against the ban Port J Public Health 2022;40:188-202 DOI: 10.1159/000527971 aim to keep [74], the global mesothelioma burden is unclear [75].…”

Section: Summary Of Evidencementioning

confidence: 99%

“…Surveillance programmes are recognized for providing an understanding of the health effects of exposure to asbestos [79] but also to improve clinical outcomes such as duration of survival and quality of life and to support research to advances in the detection, treatment, and prevention [80]. In that sense, a few countries, such as Italy and France in Europe, are among those that are most sensitive to the prevention and control of asbestos-related diseases, having a specific system of epidemiological surveillance of mesothelioma [5,12,81].…”

Section: Summary Of Evidencementioning

confidence: 99%

“…Since 2004, the World Health Organization (WHO) estimates that approximately 125 million individuals were exposed to asbestos at their workplace and that 107,000 deaths and 1,523,000 disability-adjusted life years occurred each year as a result of diseases related to their exposure [6,7]. Asbestos can cause diseases such as lung, laryngeal, ovarian, and gastrointestinal cancer, asbestosis, and mesothelioma [8-10], but it is malignant pleural mesothelioma (MPM), of monofactorial origin, that has been assumed to be the determining factor in the study of this subject [5,8,11,12]. Although the relationship between asbestos exposure and MPM is well known [13], the most studied occupational agent since 1965 with more than 12,000 bibliographic references on MEDLINE, many of the published studies is related to litigation against asbestos manufacturers, suppliers, and providers of asbestos-containing products [14] leading to the fact that much is still unknown about asbestos consumption and its location, as well as about incidence and mortality from MPM.…”

Section: Introductionmentioning

confidence: 99%

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Asbestos Exposure and Malignant Pleural Mesothelioma: A Systematic Review of Literature

Santos

Dixe

Sacadura‐Leite

et al. 2022

Port J Public Health

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Background:The relationship between exposure to asbestos and malignant pleural mesothelioma (MPM) is already well established. Nevertheless, much remains to be known about exposure thereto and the incidence and mortality from MPM. Objective: This systematic review aims to map the relationship between asbestos and MPM by studying the exposure to asbestos and the incidence and mortality of MPM. Methods: A systematic review was conducted relating asbestos and MPM. Exposure to asbestos, incidence, and mortality by MPM was reviewed. PubMed, Web of Science, Cochrane Library, RCAAP, DART-Europe, and the reference lists of included studies were searched, from January 1, 1960, to December 31, 2020. Methodological quality was checked, the risk of bias analysis was performed, a level of evidence grade was assigned, and descriptive data analysis was performed. Results: 3,484 unique citations were identified, which included seventeen observational studies that met inclusion criteria with a total of 1,104 patients. Heterogeneity is present between the included studies which range from a case series of 16 retrospective studies and 1 prospective study. Studies were mostly conducted in Europe, particularly in Italy (6), and were published between 1969 and 2020. The mean age of patients is approximately 66 years with a latency period between the first exposure and diagnosis of approximately 42 years. 14 studies present data regarding the occupational context and chrysotile and crocidolite are the most studied types of fibre. The incidence of cases occurred between the interval 1966 and 2014 and in 9 studies the mortality rate was 100% of patients. Conclusion: There is high evidence to support the relationships between asbestos and MPM. However, the relatively scant information provided by the studies reinforces the need for well-conducted research and implementation of National Mesothelioma Surveillance Centres at a global level.

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Section: Risk Of Bias (Quality) Assessmentmentioning

confidence: 99%

Section: Summary Of Evidencementioning

confidence: 99%

Section: Summary Of Evidencementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Asbestos Exposure and Malignant Pleural Mesothelioma: A Systematic Review of Literature

Santos

Dixe

Sacadura‐Leite

et al. 2022

Port J Public Health

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Disentangling heterogeneity of Malignant Pleural Mesothelioma through deep integrative omics analyses

Mangiante

Alcala

Génova

et al. 2021

Preprint

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Malignant Pleural Mesothelioma (MPM) is an aggressive cancer with rising incidence and challenging clinical management. Using the largest series of whole-genome sequencing data integrated with transcriptomic and epigenomic data using multi-omic factor analysis, we demonstrate that MPM heterogeneity arises from four sources of variation: tumor cell morphology, ploidy, adaptive immune response, and CpG island methylator phenotype. Previous genomic studies focused on describing only the tumor cell morphology factor, although we robustly find the three other sources in all publicly available cohorts. We prove how these sources of variation explain the biological functions performed by the cancer cells, and how genomic events shape MPM molecular profiles. We show how these new sources of variation help understand the heterogeneity of the clinical behavior of MPM and drug responses measured in cell lines. These findings unearth the interplay between MPM functional biology and its genomic history, and ultimately, inform classification, prognostication and treatment.

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Programme national de surveillance du mésothéliome pleural (PNSM) : vingt années de surveillance des cas, de leurs expositions et de leur reconnaissance médico-sociale (1998-2017)

Cited by 2 publications

References 0 publications

Asbestos Exposure and Malignant Pleural Mesothelioma: A Systematic Review of Literature

Asbestos Exposure and Malignant Pleural Mesothelioma: A Systematic Review of Literature

Disentangling heterogeneity of Malignant Pleural Mesothelioma through deep integrative omics analyses

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