Programmable motion control and trajectory manipulation of microparticles through tri-directional symmetrical acoustic tweezers

Wang, Yancheng; Pan, Hemin; Mei, Deqing; Xu, Chengyao; Weng, Wanyu

doi:10.1039/d2lc00046f

Cited by 21 publications

(11 citation statements)

References 50 publications

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“…[136] When the trough is reached, the cells stop moving. The acoustic radiation force F rad is defined as [94,137] F rad ¼ Àφ…”

Section: Acoustic Field Methodsmentioning

confidence: 99%

“…Of course, it can also measure the mechanical properties of cells. [ 94 ] The cells were polarized in the AC electric field and rotated polarized under the action of DEP. In general, it requires at least three flat electrodes to generate a rotating electric field.…”

Section: Single‐cell Pose Adjustment Methodsmentioning

confidence: 99%

“…[ 136 ] When the trough is reached, the cells stop moving. The acoustic radiation force

F_{rad}

is defined as [ 94,137 ]

F_{rad} = - φ (\frac{π P_{0}^{2} V_{normalp} β_{normalf}}{2 λ}) \sin (2 k x)

φ = \frac{5 ρ_{normalp} - 2 ρ_{normalf}}{2 ρ_{normalp} + ρ_{normalf}} - \frac{β_{normalp}}{β_{normalf}}

where

P_{0}

denotes the acoustic pressure amplitude,

V_{normalp}

represents the volume of the particle, λ expresses the acoustic wavelength,

V_{normalp}

denotes the wave numbers, ρ and β are compressibility of the particle and compressibility of the medium, respectively. Subscripts f and p represent fluid and particle, respectively.…”

Section: Single‐cell Pose Adjustment Methodsmentioning

confidence: 99%

See 2 more Smart Citations

A Review of Single‐Cell Pose Adjustment and Puncture

Guo

Zhang

Jin

et al. 2022

Advanced Intelligent Systems

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Single‐cell manipulation technology is an essential method of cell research, with wide applications in biological engineering, medical engineering, agricultural engineering, and other precise manipulation fields. Cell pose adjustment and cell puncture are considered as two basic operations of single‐cell manipulation. Cell pose adjustment can be used for cell sorting, cell trapping, cell orientation, cell transportation, etc. It consists of direct contact manipulation methods and noncontact manipulation methods (e.g., mechanical contact method, electric field, optical field, magnetic field, acoustic field, and hydrodynamic methods). Cell puncture consists of ordinary glass needle puncture methods, piezoelectric‐assisted puncture methods, and rotational oscillatory drill puncture methods. It aims to achieve directional and quantified injection or sampling with minimal damage. Herein, the recent research progress on single‐cell pose adjustment and puncture methods is systematically summarized and discussed, which involves the basic mechanism, characteristics, limitations, and applications. Some potential directions for future research are proposed in accordance with the above analysis. It is hoped that this review can provide a reference for academic research and industrial applications of single‐cell manipulation technology.

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“…[136] When the trough is reached, the cells stop moving. The acoustic radiation force F rad is defined as [94,137] F rad ¼ Àφ…”

Section: Acoustic Field Methodsmentioning

confidence: 99%

Section: Single‐cell Pose Adjustment Methodsmentioning

confidence: 99%

“…[ 136 ] When the trough is reached, the cells stop moving. The acoustic radiation force

F_{rad}

is defined as [ 94,137 ]

F_{rad} = - φ (\frac{π P_{0}^{2} V_{normalp} β_{normalf}}{2 λ}) \sin (2 k x)

φ = \frac{5 ρ_{normalp} - 2 ρ_{normalf}}{2 ρ_{normalp} + ρ_{normalf}} - \frac{β_{normalp}}{β_{normalf}}

where

P_{0}

denotes the acoustic pressure amplitude,

V_{normalp}

represents the volume of the particle, λ expresses the acoustic wavelength,

V_{normalp}

denotes the wave numbers, ρ and β are compressibility of the particle and compressibility of the medium, respectively. Subscripts f and p represent fluid and particle, respectively.…”

Section: Single‐cell Pose Adjustment Methodsmentioning

confidence: 99%

See 1 more Smart Citation

A Review of Single‐Cell Pose Adjustment and Puncture

Guo

Zhang

Jin

et al. 2022

Advanced Intelligent Systems

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“…6,7 The simultaneous manipulation of highthroughput microparticles along complex trajectories has become an urgent interdisciplinary demand in numerous applications. [8][9][10] Several techniques have been proposed and employed to manipulate multiple microparticles, including optical tweezers, [11][12][13] electrical tweezers, [14][15][16] magnetic tweezers, 17,18 and acoustic tweezers. 19,20 Optical and electrical tweezers can manipulate multiple microparticles at the same time.…”

Section: Introductionmentioning

confidence: 99%

High-throughput and directed microparticle manipulation in complex-shaped maze chambers based on travelling surface acoustic waves

Weng

Pan

Wang

2022

Analyst

Self Cite

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“…31 In addition, by adjusting the parameters of the sound field, the microparticles can be programmatic controlled, which can greatly simplify the operation. 32 Such microparticle manipulation has shown great potential in chemical and biological research. 33 Herein, we developed a programmable microparticle-arraybased acoustic microchip for in situ simultaneous multiple miRNAs detection.…”

mentioning

confidence: 99%

Programmable Microparticle Array for In Situ Modification and Multiple miRNA Detection

et al. 2022

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Simultaneous detection of multiple miRNAs of one disease can greatly reduce misdiagnosis and improve the detection rate, which is helpful for early cancer diagnosis. Here, a programmable microparticle-array-based acoustic microchip for in situ simultaneous multiple miRNAs detection is developed. On this microchip, the multiple probes-labeled microparticle array can be procedurally arranged in a microfluidic reaction chamber when four orthogonally piezoelectric transducers are applied. The probes-labeled microparticle array offers a platform for full molecular contact under dynamic ultrasonic streaming, and the array supplies a multipoint data correction to reduce the false positive of the detection results for more precisely visible fluorescence multiple target miRNAs sensing. We employed miRNA-21, miRNA-210, and miRNA-155 as specific biomarkers of pancreatic cancer and successfully finished the multiple miRNAs simultaneous detection in the microchip with a detection limit of 139.1, 179.9, and 111.4 pM, respectively. Such a device is programmable by adjusting the imputing frequency and voltage, and target biomarkers can be easily collected when the ultrasound force is released for further analysis, which shows great potential in multiple miRNAs enrichment and simultaneous detection for cancer clinical diagnosis.

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Programmable motion control and trajectory manipulation of microparticles through tri-directional symmetrical acoustic tweezers

Abstract: Acoustic tweezers based on travelling surface acoustic waves (TSAWs) have the potential for contactless trajectory manipulation and motion-parameter regulation of microparticles in biological and microfluidic applications. Here, we present a...

Cited by 21 publications

References 50 publications

A Review of Single‐Cell Pose Adjustment and Puncture

A Review of Single‐Cell Pose Adjustment and Puncture

High-throughput and directed microparticle manipulation in complex-shaped maze chambers based on travelling surface acoustic waves

Programmable Microparticle Array for In Situ Modification and Multiple miRNA Detection

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