Programmable autonomous micromixers and micropumps

Agarwal, A.K.; Sridharamurthy, S.S.; Beebe, David J.; Jiang, Hongrui

doi:10.1109/jmems.2005.859101

Cited by 104 publications

(62 citation statements)

References 32 publications

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“…Stimuli-responsive hydrogels, which can cycle between expanded and condensed states in response to environmental triggers (e.g., pH, ionic strength), could provide an alternative means to control precise microscopic motions, potentially through the action of multiple, independent components functioning in concert. Indeed, hydrogels have been successfully used as actuating mechanisms in microfluidic devices, functioning as stimuli-responsive valves (11,12), pumps (13), clutches (14), and optics (15). The possibility for exploiting hydrogel components in integrated microscale devices has fueled interest in the development of materials that confer greater control over stimuli-response characteristics as well as materialsfabrication strategies that provide high-resolution topographic control of hydrogel features.…”

mentioning

confidence: 99%

Multiphoton fabrication of chemically responsive protein hydrogels for microactuation

Kaehr

Shear

2008

Proc. Natl. Acad. Sci. U.S.A.

185

184

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We report a method for creating stimuli-responsive biomaterials in which scanning nonlinear excitation is used to photocrosslink proteins at submicrometer 3D coordinates. Proteins with differing hydration properties can be combined to achieve tunable volume changes that are rapid and reversible in response to changes in chemical environment. Protein matrices having arbitrary 3D topographies and definable density gradients over micrometer dimensions provide the ability to effect rapid (<1 sec) and precise mechanical manipulations by means of changes in hydrogel size and shape, and applicability of these materials to cell biology is shown through the fabrication of responsive bacterial cages.Escherichia coli ͉ multiphoton lithography ͉ nanobiotechnology ͉ protein hydrogels ͉ smart materials

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mentioning

confidence: 99%

Multiphoton fabrication of chemically responsive protein hydrogels for microactuation

Kaehr

Shear

2008

Proc. Natl. Acad. Sci. U.S.A.

185

184

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“…The significant advantages of microlens devices described here are that they respond self-adaptively to environmental parameters, thus bypassing the need for complicated external control systems and even power supplies, and that they have the potential to function as sensors to sense complicated parameters. In addition, integration of the microlens devices with microfluidic components (i.e., channels, wells, mixers, and valves) [21] is possible through liquid-phase photopolymerization, allowing the implementation of functionally complex microsystems to advance physical/chemical/biological sensing, photonics, and lab-on-chip technologies.…”

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confidence: 99%

Variable‐Focus Liquid Microlenses and Microlens Arrays Actuated by Thermoresponsive Hydrogels

2007

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“…Reproduced with permission critical solution temperature (LCST), the gel becomes hydrophobic, shrinks and forms pores which allow the solution to flow. A concept where the temperature-sensitive hydrogel was used indirectly to realize programmable autonomous micromixers and micropumps was presented in [131]: The gel operates as a temperature (and/or pH)-sensitive clutch which controls the movement of magnetically driven rotors integrated into a microfluidic device. The pH-and temperature-sensitive hydrogel poly(DMAEMA-HEMA) is used as a clutch which stops the rotation of an externally driven nickel impeller when the temperature is decreased, and starts rotating again when the temperature increases.…”

Section: Temperature-sensitive Phsmentioning

confidence: 99%

Stimulus-active polymer actuators for next-generation microfluidic devices

Hilber

2016

Appl. Phys. A

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Microfluidic devices have not yet evolved into commercial off-the-shelf products. Although highly integrated microfluidic structures, also known as lab-on-a-chip (LOC) and micrototal-analysis-system (lTAS) devices, have consistently been predicted to revolutionize biomedical assays and chemical synthesis, they have not entered the market as expected. Studies have identified a lack of standardization and integration as the main obstacles to commercial breakthrough. Soft microfluidics, the utilization of a broad spectrum of soft materials (i.e., polymers) for realization of microfluidic components, will make a significant contribution to the proclaimed growth of the LOC market. Recent advances in polymer science developing novel stimulus-active soft-matter materials may further increase the popularity and spreading of soft microfluidics. Stimulus-active polymers and composite materials change shape or exert mechanical force on surrounding fluids in response to electric, magnetic, light, thermal, or water/solvent stimuli. Specifically devised actuators based on these materials may have the potential to facilitate integration significantly and hence increase the operational advantage for the end-user while retaining costeffectiveness and ease of fabrication. This review gives an overview of available actuation concepts that are based on functional polymers and points out promising concepts and trends that may have the potential to promote the commercial success of microfluidics.

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Programmable autonomous micromixers and micropumps

Cited by 104 publications

References 32 publications

Multiphoton fabrication of chemically responsive protein hydrogels for microactuation

Multiphoton fabrication of chemically responsive protein hydrogels for microactuation

Variable‐Focus Liquid Microlenses and Microlens Arrays Actuated by Thermoresponsive Hydrogels

Stimulus-active polymer actuators for next-generation microfluidic devices

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