Prognostication for oral carcinomas based on two histological scoring systems (BD and iBD models)

Domingueti, Catherine Bueno; Miwa, K; Dourado, Maurício Rocha; Sawazaki‐Calone, Íris; Salo, Tuula; Paranaíba, Lívia Máris Ribeiro; Coletta, Ricardo D.

doi:10.1111/odi.13595

Cited by 4 publications

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“…In fact, studies have shown that tumor budding is composed of cells exhibiting typical features of epithelial mesenchymal transition, with increasing invasiveness (71). Across multiple studies, increased tumor budding density is associated with histological criteria of poor OSCC outcomes (72)(73)(74). In our meta-analyses, tumor budding was an independent prognostic factor of OS, DSS, and DFS.…”

Section: Discussionmentioning

confidence: 56%

The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis

et al. 2021

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ObjectiveOver many decades, studies on histopathological features have not only presented high-level evidence of contribution for treatment directions and prognosis of oral squamous cell carcinoma (OSCC) but also provided inconsistencies, making clinical application difficult. The 8th TNM staging system of OSCC has acknowledged the importance of some histopathological features, by incorporating depth of invasion (DOI) to T category and extranodal extension (ENE) to N category. The aim of this systematic review with meta-analysis is to determine the most clinically relevant histopathological features for risk assessment and treatment planning of OSCC and to elucidate gaps in the literature.MethodsA systematic review was conducted using PRISMA guidelines, and the eligibility criteria were based on population, exposure, comparison, outcome, and study type (PECOS). PubMed, Cochrane, Scopus, and Web of Science were searched for articles exploring the impact of histopathological features on OSCC outcomes with Cox multivariate analysis. Pooled data were subjected to an inverse variance method with random effects or fixed effect model, and the risk of bias was evaluated using quality in prognosis studies (QUIPS). Quality of evidence was assessed with the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria.ResultsThe study included 172 articles published from 1999 to 2021. Meta-analyses confirmed the prognostic potential of DOI, ENE, perineural invasion, lymphovascular invasion, and involvement of the surgical margins and brought promising results for the association of bone invasion, tumor thickness, and pattern of invasion with increased risk for poor survival. Although with a small number of studies, the results also revealed a clinical significance of tumor budding and tumor-stroma ratio on predicted survival of patients with OSCC. Most of the studies were considered with low or moderate risk of bias, and the certainty in evidence varied from very low to high.ConclusionOur results confirm the potential prognostic usefulness of many histopathological features and highlight the promising results of others; however, further studies are advised to apply consistent designs, filling in the literature gaps to the pertinence of histopathological markers for OSCC prognosis.Systematic Review RegistrationInternational Prospective Register of Systematic Reviews (PROSPERO), identifier CRD42020219630.

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Section: Discussionmentioning

confidence: 56%

The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis

et al. 2021

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“…Single cut-off: 3 buds/field [ 31 , 32 , 44 , 64 ] 4 buds/field [ 55 ] 5 buds/fields [ 16 , 23 , 24 , 26 , 29 , 33 , 34 , 37 , 38 , 40 , 43 , 53 , 58 , 59 , 60 , 63 , 64 , 67 , 69 , 71 ] 10 buds/field [ 15 , 19 , 61 , 62 ] 15 buds/field [ 24 ] …”

Section: Tumor Budding In Oral Squamous Cell Carcinomamentioning

confidence: 99%

“…5 buds/fields [ 16 , 23 , 24 , 26 , 29 , 33 , 34 , 37 , 38 , 40 , 43 , 53 , 58 , 59 , 60 , 63 , 64 , 67 , 69 , 71 ]…”

Section: Tumor Budding In Oral Squamous Cell Carcinomaunclassified

“…n. of HPF evaluated: 1, 5, 10 1 [ 5 , 15 , 16 , 18 , 19 , 23 , 24 , 25 , 26 , 28 , 29 , 30 , 32 , 34 , 36 , 37 , 38 , 40 , 43 , 44 , 53 , 54 , 55 , 56 , 57 , 60 , 61 , 62 , 63 , 64 , 65 , 67 , 68 , 69 , 71 , 73 , 74 ] 5 [ 15 , 33 ] 10 [ 19 , 24 , 66 …”

Section: Tumor Budding In Oral Squamous Cell Carcinomaunclassified

“…1 [ 5 , 15 , 16 , 18 , 19 , 23 , 24 , 25 , 26 , 28 , 29 , 30 , 32 , 34 , 36 , 37 , 38 , 40 , 43 , 44 , 53 , 54 , 55 , 56 , 57 , 60 , 61 , 62 , 63 , 64 , 65 , 67 , 68 , 69 , 71 , 73 , 74 ]…”

Section: Tumor Budding In Oral Squamous Cell Carcinomaunclassified

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The Emerging Impact of Tumor Budding in Oral Squamous Cell Carcinoma: Main Issues and Clinical Relevance of a New Prognostic Marker

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Caponio

Zerman

et al. 2022

Cancers

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Tumor Budding (TB) represents a single cancer cell or a small cluster of less than five cancer cells on the infiltrative tumor front. Accumulating evidence suggests TB is an independent prognostic factor in oral squamous cell carcinoma (OSCC). However, its exact role is not yet elucidated, and a standardized scoring system is still necessary. The study aims to extensively review the literature data regarding the prognostic role of TB in OSCC. The results of TB are an independent prognostic factor of poor survival outcomes in OSCC. To date, the manual detection of hematoxylin and eosin-staining or pancytokeratin-immunostaining sections are the most commonly used methods. Between the several cut-offs, the two-tier system with five buds/field cut-offs provides better risk stratification. The prognostic role of the BD model in predicting survival outcomes was extensively validated; however, the inclusion of DOI, which is already a staging parameter, encouraged other authors to propose other models, integrating TB count with other adverse risk factors, such as the tumor–stroma ratio and tumor-infiltrated lymphocytes. The prognostic relevance of TB in OSCC highlights its evaluation in daily pathological practice. Therefore, the TB detection method and the TB scoring system should be validated based on tumor stage and site.

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Prognostic significance of tumor budding thresholds in oral tongue squamous cell carcinoma

et al. 2022

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Prognostication for oral carcinomas based on two histological scoring systems (BD and iBD models)

Cited by 4 publications

References 21 publications

The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis

The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis

The Emerging Impact of Tumor Budding in Oral Squamous Cell Carcinoma: Main Issues and Clinical Relevance of a New Prognostic Marker

Prognostic significance of tumor budding thresholds in oral tongue squamous cell carcinoma

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