Prognostic values of S100 family members in ovarian cancer patients

Abstract

ObjectiveExhibiting high consistence in sequence and structure, S100 family members are interchangeable in function and they show a wide spectrum of biological processes, including proliferation, apoptosis, migration, inflammation and differentiation and the like. While the prognostic value of each individual S100 in ovarian cancer is still elusive. In current study, we investigated the prognostic value of S100 family members in the ovarian cancer.MethodsWe used the Kaplan Meier plotter (KM plotter) database, in which updated gene expression data and survival information are from 1657 ovarian cancer patients, to assess the relevance of individual S100 family mRNA expression to overall survival in various ovarian cancer subtypes and different clinicopathological features.ResultsIt was found that high expression of S100A2 (HR = 1.18, 95%CI: 1.04–1.34, P = 0.012), S100A7A (HR = 1.3, 95%CI: 1.04–1.63, P = 0.02),S100A10 (HR = 1.2, 95%CI: 1.05–1.38, P = 0.0087),and S100A16 (HR = 1.23, 95%CI: 1–1.51, P = 0.052) were significantly correlated with worse OS in all ovarian cancer patients, while the expression of S100A1 (HR = 0.87, 95%CI: 0.77–0.99, P = 0.039), S100A3 (HR = 0.83, 95%CI: 0.71–0.96, P = 0.0011), S100A5 (HR = 0.84, 95%CI: 0.73–0.97, P = 0.017), S100A6 (HR = 0.84, 95%CI: 0.72–0.98, P = 0.024), S100A13 (HR = 0.85, 95%CI:0.75–0.97, P = 0.014) and S100G (HR = 0.86, 95%CI: 0.74–0.99, P = 0.041) were associated with better prognosis. Furthermore, we assessed the prognostic value of S100 expression in different subtypes and the clinicopathological features, including pathological grades, clinical stages and TP53 mutation status, of ovarian cancer patients.ConclusionComprehensive understanding of the S100 family members may have guiding significance for the diagnosis and outcome of ovarian cancer patients.Electronic supplementary materialThe online version of this article (10.1186/s12885-018-5170-3) contains supplementary material, which is available to authorized users.

Changes in Serum and Salivary Proteins in Canine Mammary Tumors

“…Higher tissue expression of S100A2 was significantly correlated with worse overall survival in ovarian cancer patients [15], and S100A2 protein expression in saliva was observed to be higher in oral squamous cell carcinoma patients in comparison to other oral potentially malignant disorders. S100A6 expression has been associated with worse prognosis or the progression of several cancers including oncogynecology [50], colorectal [51], gastric [52], and renal [53]. In contrast, a recent study suggests a relation between S100A6 expression and better prognosis in breast cancer [54].…”

Friend or Foe: S100 Proteins in Cancer

“…Recent studies investigating mRNA expression of S100 proteins in correlation with the survival of ovarian cancer patients demonstrated that high levels of the S100 family members S100A2, S100A10, S100A11, S100A15, S100A16, and S100B predict worse OS, while S100A1, S100A3, S100A5, S100A6, S100A13, S100G, and S100Z are associated with longer OS, partially depending on cancer subtype and clinicopathological features [144,145]. However, the underlying mechanisms of these S100 proteins in the context of ovarian cancer have not yet been fully understood.…”

GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis

“…Armed with functionalities such as differential expression analysis, survival analysis, and similar gene identification, GEPIA provided experimental biologists and clinicians with a handy tool to explore TCGA and GTEx datasets. GEPIA has aided the investigation of various genes in multiple cancer types (5,6), and led to the identification of potential biomarkers (7) and therapeutic targets (8,9).…”