Prognostic value of urodynamic testing in myelodysplastic patients

McGuire, Edward J.; Woodside, Jeffrey R.; Borden, Thomas A.; Weiß, Robert M.

doi:10.1016/s0022-5347(02)80338-x

Cited by 160 publications

(173 citation statements)

References 8 publications

Supporting

Mentioning

157

Contrasting

Unclassified

Order By: Relevance

“…In female patients with both sphincter weakness and detrusor instability/hyper-re¯exia, no clinical, radiological or urodynamic feature alone or combined provide a suf®ciently accurate assessment of the state of the bladder neck and urethral continence mechanism before surgery to help decide whether or not a simultaneous antistress incontinence procedure should be undertaken [54,152]. Our view is that minor and moderate sphincter weakness should not be treated concomitantly with cystoplasty.…”

Section: Incontinencementioning

confidence: 99%

Augmentation cystoplasty

Greenwell¹,

Venn²,

Mundy³

2001

BJU International

193

137

View full text Add to dashboard Cite

Section: Incontinencementioning

confidence: 99%

Augmentation cystoplasty

Greenwell¹,

Venn²,

Mundy³

2001

BJU International

193

137

View full text Add to dashboard Cite

“…2 Amplitudes of IDC greater than 40 cm H 2 O pose a threat to the upper urinary tract. 3 Oral antimuscarinic agents have been widely used as first-line treatment for patients with NDO. However, they are ineffective in some patients and are often associated with bothering side effects such as dry mouth, constipation and blurred vision.…”

Section: Introductionmentioning

confidence: 99%

Are oxybutynin and trospium efficacious in the treatment of detrusor overactivity in spinal cord injury patients?

Hadiji¹,

Prévinaire

Benbouzid³

et al. 2014

Spinal Cord

View full text Add to dashboard Cite

Objectives: To evaluate the efficacy of anticholinergic agents in the treatment of neurogenic overactive bladder (NOAB) and neurogenic detrusor overactivity (NDO) in spinal cord injury (SCI) patients on clean intermittent catheterisation (CIC). Methods: Chronic suprasacral SCI patients on CIC presenting with at least one urinary leakage a day were included. Urodynamics and voiding diaries were performed at baseline and 1 month follow-up. In case of NDO at baseline, an anticholinergic drug was prescribed. Results: The 231 SCI patients presented with one to five urinary leakages per day (mean 2.1). Urodynamics showed NDO in all patients. A new anticholinergic treatment was started in all, either in monotherapy (134 patients) or in association with the existing anticholinergic drug (oxybutynin þ trospium bitherapy, 97 patients). The mean maximum bladder capacity significantly increased from 225 to 441 ml, and the mean involuntary detrusor contractions (IDC) significantly decreased from 67 to 41 cm H 2 O. Only 75 SCI patients (32%) were fully continent. However, 25 out of these 75 patients showed persistent NDO, with amplitudes of IDC above 40 cm H 2 O in 12 patients. Incontinence was still found in 156 SCI patients (67%), with an average of 1,2 leakages a day. In 100 patients, amplitudes of IDC remained above 40 cm H 2 O. There was no statistical difference between patients on anticholinergic monotherapy or bitherapy at follow-up. Conclusion: Anticholinergic treatment is not always satisfactory in terms of control of NDO and rarely allows full continence. INTRODUCTIONThe quality of life of patients presenting with spinal cord injury (SCI) is frequently impaired by lower urinary tract dysfunction. In supra-sacral SCI lesions, neurogenic overactive bladder (NOAB) is common, with symptoms including urgency, with or without urge incontinence, frequency and nocturia. 1 Patients with NOAB are often found to have neurogenic detrusor overactivity (NDO), an urodynamic observation characterised by involuntary detrusor contractions (IDCs) during the filling phase that is either spontaneous or provoked. 2 Amplitudes of IDC greater than 40 cm H 2 O pose a threat to the upper urinary tract. 3 Oral antimuscarinic agents have been widely used as first-line treatment for patients with NDO. However, they are ineffective in some patients and are often associated with bothering side effects such as dry mouth, constipation and blurred vision. 2,4 The clinical and urodynamic efficacy of anticholinergic agents in SCI patients has been evaluated in a limited number of studies. [5][6][7][8][9] They all showed a significant decrease in the number of leakages per day with improved quality of life. Urodynamic testing showed significant improvement in maximum bladder capacity (BCmax) and significant reduction in amplitudes of IDC. However, these were mainly short-term studies, using different evaluation criteria, with different drugs at flexible doses. Surprisingly, patients presenting with daily leakages and persistence of IDC (as high as 35...

show abstract

“…Curva en campana: paciente sano con los estudios de presión y flujo. Consiste en la instilación de un medio de contraste y en captar mediante fluoroscopia las imágenes del tracto urinario (15). Es un estudio invasivo indicado en casos seleccionados: paciente con enfermedad neurológica que afecte al tracto urinario inferior, incontinencia urinaria masculina, incontinencia urinaria femenina recidivante y compleja, obstrucción del tracto urinario femenino, paciente joven con antecedente de obstrucción del tracto urinario de salida o con antecedente de cirugía previa y paciente pediátrico con micción disfuncional o enfermedad neurológica (13).…”

Section: Diagnósticounclassified

Evaluación y tratamiento del niño con síntomas del tracto urinario inferior (LUTS)

Guerrero-Tinoco

Cano-Martínez

Vanegas-Ruiz

2018

iatreia

View full text Add to dashboard Cite

RESUMENLa disfunción miccional es un trastorno del llenado o vaciado de la vejiga en niños sin alteraciones neurológicas o anatómicas. Los síntomas del tracto urinario inferior (LUTS, por la sigla en inglés de Lower urinary tract symptoms) son un motivo frecuente de consulta con el pediatra, el nefrólogo o el urólogo pediatra, e incluso con el neurólogo y el psicólogo infantil. Se le considera una enfermedad relativamente benigna lo que en ocasiones genera desinterés entre médicos y familiares y lleva a consultas tardías e interpretación inadecuada de los síntomas. Manifestaciones como urgencia, incontinencia, enuresis, goteo posmiccional, infecciones urinarias, vulvovaginitis recurrente y constipación, en un niño sin enfermedad neurológica, deben hacer pensar al médico en disfunción miccional para enfocar oportunamente el diagnóstico, restablecer la calidad de vida del paciente, evitar las infecciones urinarias y el daño renal subsecuente e irreversible secundario a un diagnóstico tardío. Las recomendaciones actuales hacen énfasis en un enfoque menos invasivo, tratamiento conservador, manejo de la constipación y reentrenamiento vesical. Este artículo discute la evaluación, el diagnóstico y el tratamiento correctos de niños con LUTS.

show abstract

Prognostic value of urodynamic testing in myelodysplastic patients

Cited by 160 publications

References 8 publications

Augmentation cystoplasty

Augmentation cystoplasty

Are oxybutynin and trospium efficacious in the treatment of detrusor overactivity in spinal cord injury patients?

Evaluación y tratamiento del niño con síntomas del tracto urinario inferior (LUTS)

Contact Info

Product

Resources

About