Prognostic value of tumour-infiltrating lymphocytes based on the evaluation of frequency in patients with oestrogen receptor–positive breast cancer

He, Jiajia; Fu, Fangmeng; Wang, Wei; Xi, Gangqin; Guo, Wenhui; Zheng, Luyao; Ren, Wenjiao; Qiu, Lida; Huang, Xingxin; Li, Lianhuang; Kang, Deyong; Chen, Jianxin

doi:10.1016/j.ejca.2021.06.011

Cited by 14 publications

(11 citation statements)

References 33 publications

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“…sTILs were described as a prognostic factor of breast cancer in many studies 49 . Previous research revealed that the prognostic value of sTILs varies according to different molecular subtypes 50 . A meta‐analysis involving 33 studies showed that higher sTILs were associated with improved survival in HER2‐positive and TN breast cancer patients, 51 while other researchers declared sTILs as a negative prognostic factor in HoR‐positive breast cancer 20,47 .…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics, tumor‐infiltrating lymphocytes, and prognosis in HER2‐low breast cancer: A comparison study with HER2‐zero and HER2‐positive disease

Tong

Fei

et al. 2023

Cancer Medicine

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IntroductionHER2‐low breast cancer is a gradually recognized and unexplored group of diseases. We aimed to investigate the clinical and prognosis features and to identify the role of stromal tumor‐infiltrating lymphocytes (sTILs) in this population.MethodsConsecutive primary breast cancer patients treated between January 2009 to June 2013 were retrospectively reviewed. HER2‐low was defined as immunohistochemistry (IHC) 1+, or 2+ and fluorescence in situ hybridization (FISH) negative. sTILs were scored following the international guidelines. Clinicopathologic features and survival were compared according to HER2 and sTILs category.ResultsA total of 973 breast cancer patients were enrolled, including 615 (63.2%) HER2‐low patients. HER2‐low patients shared more similarity with HER2‐0 cases in clinicopathological features. sTILs in HER2‐Low patients was comparable to HER2‐0 patients (p = 0.064), both significantly lower than HER2‐positive ones (p < 0.001). Meanwhile, tumors with sTILs ≥50% accounted for the least proportion of HER2‐low cases (p < 0.001). HER2 status had no significant influence on recurrence‐free survival (RFS, p = 0.901) in the whole population. However, in the estrogen receptor (ER)‐negative subgroup, HER2‐low was related to worse RFS (p = 0.009) and OS (p = 0.001) compared with HER2‐positive ones. sTILs increment was an independent favorable prognostic factor in the whole (OS, p = 0.003; RFS, p = 0.005) and HER2‐low population (OS, p = 0.007; RFS, p = 0.009) after adjusted to clinicopathological parameters.ConclusionsHER2‐low patients shared similar clinicopathological features with HER2‐0 rather than HER2‐positive cases and had relatively low sTILs. ER‐negative/HER2‐low patients had significantly inferior survival. sTILs increment was independently associated with favorable survival in the HER2‐low group, suggesting a potential benefit from a novel treatment strategy.

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Section: Discussionmentioning

confidence: 99%

Clinical characteristics, tumor‐infiltrating lymphocytes, and prognosis in HER2‐low breast cancer: A comparison study with HER2‐zero and HER2‐positive disease

Tong

Fei

et al. 2023

Cancer Medicine

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“…We then analyzed the influence of the peritumoral infiltrate on the prognostic value of nuclear receptors. Although the prognostic value of TIL levels in the ER-negative/Her2-negative breast cancer population is well known, the impact of immune infiltration on the prognosis value of NRs was never investigated before [ 53 , 54 , 55 ]. ERα (and steroid hormone receptor expression in general) is known to be favorable concerning OS [ 56 , 57 , 58 ] in BC.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Relevance of Nuclear Receptors in Relation to Peritumoral Inflammation and Tumor Infiltration by Lymphocytes in Breast Cancer

Köpke

Château²,

Boissière³

et al. 2022

Cancers

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The prognostic impact of tumor-infiltrating lymphocytes (TILs) is intensively investigated in breast cancer (BC). It is already known that triple-negative breast cancer (TNBC), the most aggressive type of BC, has the highest percentage of TILs. In addition, there is an influence of steroid hormone receptor expression (type I nuclear receptors) on TIL subpopulations in breast cancer tissue. The link between type II nuclear receptors and the level of TILs is unclear. Therefore, the aim of this study was to quantify TILs in a panel of 264 sporadic breast cancers and investigate the correlation of TIL levels with type I and II nuclear receptors expression. TIL levels were significantly increased in the subgroup of TNBC. By contrast, they decreased in estrogen (ER)- or progesterone receptor (PR)-positive cases. Moreover, TIL levels were correlated with type II nuclear receptors, including PPARγ, with a significant inverse correlation of the nuclear form (r = −0.727, p < 0.001) and a weak positive correlation of the cytoplasmic form (r = 0.202, p < 0.002). Surprisingly, BC cases with a TIL Salgado score of >15% showed a significantly decreased overall survival. In addition, peritumoral inflammation was also quantified in BC tissue samples. In our cohort, although the level of peritumoral inflammation was not correlated with OS, it determined the prognostic value of ER, PR, and PPARγ in BC. Altogether, the present study provides a differentiated overview of the relations between nuclear receptor expression, TIL levels, peritumoral inflammation, and prognosis in BC.

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“…As described previously, we employed a commercial laser scanning confocal microscopy (LSM 880, Zeiss, Germany) in conjunction with a mode-locked femtosecond Ti: sapphire laser (Chameleon Ultra, Coherent, USA) to conduct multiphoton imaging [8][9][10]. A Plan-Apochromat 20×objective (NA = 0.8, Zeiss, Germany) was employed to acquire multiphoton images.…”

Section: Multiphoton Imagingmentioning

confidence: 99%

Application of multiphoton microscopy for studying liver fibrosis

Zhang,

Yu,

Zhang

et al. 2023

Optics in Health Care and Biomedical Optics XIII

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Prognostic value of tumour-infiltrating lymphocytes based on the evaluation of frequency in patients with oestrogen receptor–positive breast cancer

Cited by 14 publications

References 33 publications

Clinical characteristics, tumor‐infiltrating lymphocytes, and prognosis in HER2‐low breast cancer: A comparison study with HER2‐zero and HER2‐positive disease

Clinical characteristics, tumor‐infiltrating lymphocytes, and prognosis in HER2‐low breast cancer: A comparison study with HER2‐zero and HER2‐positive disease

Prognostic Relevance of Nuclear Receptors in Relation to Peritumoral Inflammation and Tumor Infiltration by Lymphocytes in Breast Cancer

Application of multiphoton microscopy for studying liver fibrosis

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