Prognostic Value of the Neutrophil–Lymphocyte Ratio in Patients With ST-Elevated Acute Myocardial Infarction

Gazı, Emıne; Bayram, Başak; Gazi, Sabri; Temız, Ahmet; Kırılmaz, Bahadır; Altun, Burak; Barutçu, Ahmet

doi:10.1177/1076029613492011

Cited by 47 publications

(47 citation statements)

References 33 publications

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“…We compared the clinical characteristics of hospital survivors and non-survivors, and found that some of laboratory tests were associated with hospital outcomes, such as RDW and potassium. These findings are partially consistent with previous reports (4)(5)(6)(7)(8)(9)(10)(11). However, we noted that percentages of basophil and eosinophil were decreased in hospital non-survivors, suggesting that eosinophil and basophil percentages are potential prognostic factors for AMI and thus unmasking a potential (new) of these blood cells in the complications of acute coronary syndrome.…”

Section: Discussionsupporting

confidence: 93%

“…For example, higher red blood cell distribution width (RDW) (4), neutrophil to lymphocyte ratio (5), mean corpuscular volume (MCV) (6), platelet count (7) and white blood cell (WBC) (8) count are associated with poorer outcomes in patients with acute myocardial infarction (AMI), while decreased Focus on State of the Art in Diagnostics of the Acute Coronary Syndrome hemoglobin is associated with higher mortality (9). In addition, serum potassium level can also impact the outcomes of AMI patients (10,11).…”

Section: Introductionmentioning

confidence: 99%

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Lower mean corpuscular hemoglobin concentration is associated with poorer outcomes in intensive care unit admitted patients with acute myocardial infarction

Huang¹,

Hu²

2016

Annals of Translational Medicine

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Background: Accumulated studies have shown that hematological parameters [e.g., red blood cell distribution width (RDW), hemoglobin, platelet count] and serum potassium level can impact the prognosis of patients with acute myocardial infarction (AMI). However, no previous study has evaluated the prognostic values of these laboratory tests simultaneously.Methods: This study is based on an intensive care unit (ICU) database named Multiparameter Intelligent Monitoring in Intensive Care II (MIMIC II). Adult patients with AMI were included, and their hematological parameters and serum ion levels on admission were extracted. The relationships between these laboratory tests and hospital mortality were evaluated using a logistic regression model and receiver operating characteristic (ROC) curve analysis. The effects of these laboratory tests on 1-year mortality were evaluated using a Cox hazard regression model and Kaplan-Meier curve analysis.Results: In univariable analysis, increased white blood cell (WBC), neutrophil percentage, mean corpuscular volume (MCV), RDW, potassium and decreased red blood cell (RBC), hemoglobin, mean corpuscular hemoglobin concentration (MCHC), hematocrit and percentage of lymphocyte, monocyte, basophil and eosinophil were significantly associated with hospital mortality. In multivariable analyses, basophil percentage, potassium, WBC and MCHC were independently associated with hospital morality, while WBC, RDW, MCHC, potassium and percentages of neutrophil and lymphocyte were associated with 1-year mortality.Conclusions: Hematological parameters and serum potassium can provide prognostic information in AMI patients. MCHC is an independent prognostic factor for both short and long term outcomes of AMI.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Lower mean corpuscular hemoglobin concentration is associated with poorer outcomes in intensive care unit admitted patients with acute myocardial infarction

Huang¹,

Hu²

2016

Annals of Translational Medicine

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“…Similar to stable CAD patients, elevated NLR prognosticates adverse outcome in ACS patients as shown by several studies both at short term, i.e., <30 days (88, 89, 91, 97–99), and long term, i.e., >6 months, of follow-up (74, 75, 83, 89, 91–93, 97, 102) with an average fourfold increased risk. Only in two studies, the NLR was not independently associated with MACE and CVD mortality (87, 90).…”

Section: Neutrophil To Lymphocyte Ratiomentioning

confidence: 75%

Prognostic Value of Circulating Inflammatory Cells in Patients with Stable and Acute Coronary Artery Disease

Meeuwsen

Wesseling

Hoefer

et al. 2017

Front. Cardiovasc. Med.

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Atherosclerosis is a lipid driven chronic inflammatory disease underlying the majority of ischemic events such as myocardial infarction or stroke. Clinical management of ischemic events has improved considerably in the past decades. Accordingly, survival rates have increased. Nevertheless, 12% of patients die within 6 months after the initial event. To improve secondary prevention, appropriate risk prediction is key. However, up to date, there is no clinically available routine marker to identify patients at high risk for recurrent cardiovascular events. Due to the central role of inflammation in atherosclerotic lesion progression and destabilization, many studies have focused on the role of circulating inflammatory cells in these processes. This review summarizes the current evidence on the potential of circulating inflammatory cells as biomarkers for recurrent adverse manifestations in acute coronary syndrome and stable coronary artery disease patients.

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“…Yılmaz et al24) reported that NLR was significantly increased in patients with coronary thrombus formation in non-ST segment elevated acute coronary syndrome. Gazi et al25) showed that a high NLR is a strong and independent predictor of inpatient mortality among patients with ST-segment elevated MI. Yayla et al26) demonstrated that PLR is independently associated with saphenous venous graft disease.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil Lymphocyte Ratio as a Predictor of Left Ventricular Apical Thrombus in Patients with Myocardial Infarction

Ertem¹,

Özçelik²,

Kasapkara

et al. 2016

Korean Circ J

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Background and ObjectivesIn this study, we examined the role of inflammatory parameters in an apical mural thrombus with a reduced ejection fraction due to large anterior myocardial infarction (MI).Subjects and MethodsA total of 103 patients who had suffered from heart failure, 45 of whom had left ventricular apical thrombus (AT) after a large anterior MI, were enrolled in the study. A detailed clinical history was taken of each participant, biochemical inflammatory markers, which were obtained during admission, were analyzed and an echocardiographical and angiographical evaluation of specific parameters were performed.ResultsThere were no statistically significant differences in terms of age, gender, and history of hypertension, diabetes mellitus, and atrial fibrillation between both groups (p>0.05). Similarly there were no statistically significant differences in terms of biochemical and echocardiographic parameters (p>0.05). However, there were significant differences in terms of neutrophil lymphocyte ratio (p=0.032). After a multivariate regression analysis, neutrophil lymphocyte ratio (NLR) was an independent predictor of thrombus formation (β: 0.296, p=0.024). The NLR >2.74 had a 78% sensivity and 61% specifity in predicting thrombus in patients with a low left ventricular ejection fraction.ConclusionIn this study, neutrophil lymphocyte ratios were significantly higher in patients with apical thrombus.

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Prognostic Value of the Neutrophil–Lymphocyte Ratio in Patients With ST-Elevated Acute Myocardial Infarction

Cited by 47 publications

References 33 publications

Lower mean corpuscular hemoglobin concentration is associated with poorer outcomes in intensive care unit admitted patients with acute myocardial infarction

Lower mean corpuscular hemoglobin concentration is associated with poorer outcomes in intensive care unit admitted patients with acute myocardial infarction

Prognostic Value of Circulating Inflammatory Cells in Patients with Stable and Acute Coronary Artery Disease

Neutrophil Lymphocyte Ratio as a Predictor of Left Ventricular Apical Thrombus in Patients with Myocardial Infarction

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