Prognostic Value of Circulating Inflammatory Cells in Patients with Stable and Acute Coronary Artery Disease

Meeuwsen, John A. L.; Wesseling, Marian; Hoefer, Imo E.; Jager, Saskia C.A. de

doi:10.3389/fcvm.2017.00044

Cited by 24 publications

(23 citation statements)

References 113 publications

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“…Identifying a high-risk pattern of circulating inflammatory cells may have prognostic value for secondary prevention in ischaemic patients. According to Meeuwsen's recent review, elevated numbers of neutrophils appear to be consistently related to adverse outcomes in CAD and post-AMI patients and, despite the limited existing data, adds significant prognostic value in addition to common prediction calculators such as GRACE and the TIMI score ( 45 ).…”

Section: The Heart As An Immune Organmentioning

confidence: 99%

Stress and Inflammation in Coronary Artery Disease: A Review Psychoneuroendocrineimmunology-Based

et al. 2018

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Recent findings have deeply changed the current view of coronary heart disease, going beyond the simplistic model of atherosclerosis as a passive process involving cholesterol build-up in the subintimal space of the arteries until their final occlusion and/or thrombosis and instead focusing on the key roles of inflammation and the immune system in plaque formation and destabilization. Chronic inflammation is a typical hallmark of cardiac disease, worsening outcomes irrespective of serum cholesterol levels. Low-grade chronic inflammation correlates with higher incidence of several non-cardiac diseases, including depression, and chronic depression is now listed among the most important cardiovascular risk factors for poor prognosis among patients with myocardial infarction. In this review, we include recent evidence describing the immune and endocrine properties of the heart and their critical roles in acute ischaemic damage and in post-infarct myocardial remodeling. The importance of the central and autonomic regulation of cardiac functions, namely, the neuro-cardiac axis, is extensively explained, highlighting the roles of acute and chronic stress, circadian rhythms, emotions and the social environment in triggering acute cardiac events and worsening heart function and metabolism in chronic cardiovascular diseases. We have also included specific sections related to stress-induced myocardial ischaemia measurements and stress cardiomyopathy. The complex network of reciprocal interconnections between the heart and the main biological systems we have presented in this paper provides a new vision of cardiovascular science based on psychoneuroendocrineimmunology.

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Section: The Heart As An Immune Organmentioning

confidence: 99%

Stress and Inflammation in Coronary Artery Disease: A Review Psychoneuroendocrineimmunology-Based

et al. 2018

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“…NLR is shown to be associated with chronic kidney disease, major cardiovascular events, and hospitalizations for HF in elderly patients [20]. NLR was an independent predictor of outcome in patients with stable coronary artery disease (CAD) and a predictor of short- and long-term mortality in patients with acute coronary syndromes (ACS), ST-elevation myocardial infarction (STEMI), and cardiac transplantation [31–33]. Despite the prominent role of neutrophils in inducing the chronic inflammatory response in the pathogenesis of many diseases, neutrophil-targeted treatments are still not available [34].…”

Section: Immune Cells In the Heartmentioning

confidence: 99%

Role of Inflammatory Cell Subtypes in Heart Failure

Strassheim

Dempsey

Gerasimovskaya

et al. 2019

Journal of Immunology Research

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Inflammation is a well-known feature of heart failure. Studies have shown that while some inflammation is required for repair during injury and is protective, prolonged inflammation leads to myocardial remodeling and apoptosis of cardiac myocytes. Various types of immune cells are implicated in myocardial inflammation and include neutrophils, macrophages, eosinophils, mast cells, natural killer cells, T cells, and B cells. Recent clinical trials have targeted inflammatory cascades as therapy for heart failure with limited success. A better understanding of the temporal course of the infiltration of the different immune cells and their contribution to the inflammatory process may improve the success for therapy. This brief review outlines the major cell types involved in heart failure, and some of their actions are summarized in the supplementary figure.

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“…Inflammation is a critical pathological factor in multiple major diseases including cerebral ischemia (24), acute myocardial infarction (23), stable coronary artery disease (15), Parkinson's disease (21) and lung cancer (19). A number of proinflammatory and anti-inflammatory cytokines are important mediators of inflammation (1- 5,9,12,14,16,25,27).…”

Section: Introductionmentioning

confidence: 99%

Epidermal green autofluorescence intensity is significantly associated with the serum levels of multiple cytokines of LPS-exposed mice

Zhang

Yang

et al. 2019

Preprint

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Inflammation plays various crucial pathological and physiological roles, in which a number of pro-inflammatory and anti-inflammatory cytokines are important mediators. It is of great scientific and clinical significance to search for non-invasive approaches for evaluating cytokine levels in the blood. Our previous study reported that epidermal green autofluorescence (AF) intensity of LPS-exposed mice is highly correlated with LPS doses. In our current study, we determined if epidermal green AF intensity is associated with the serum levels of various cytokines in the LPSexposed mice. We found that both epidermal green AF intensity and LPS doses are significantly associated with the serum levels of key cytokines including interleukin-1β (IL-1β), IL-6 and IL-10. Both epidermal green AF intensity and LPS doses are also significantly associated with the pro-inflammatory factors including IL-2, IL-12(p40), monocyte chemoattractant protein-1 (MCP-1), MIP-1α, MIP-1β, and regulated on activation, normal T cell expressed and secreted (RANTES/CCL5), as well as anti-inflammatory factors including IL-5 and granulocyte colony stimulating factor (G-CSF). Our findings have suggested that detection of epidermal green AF intensity may become first approach for non-invasive evaluation of certain cytokine levels in human body, which could profoundly enhance our capacity to evaluate inflammation levels for monitoring health state, disease state and therapeutic effects.

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Prognostic Value of Circulating Inflammatory Cells in Patients with Stable and Acute Coronary Artery Disease

Cited by 24 publications

References 113 publications

Stress and Inflammation in Coronary Artery Disease: A Review Psychoneuroendocrineimmunology-Based

Stress and Inflammation in Coronary Artery Disease: A Review Psychoneuroendocrineimmunology-Based

Role of Inflammatory Cell Subtypes in Heart Failure

Epidermal green autofluorescence intensity is significantly associated with the serum levels of multiple cytokines of LPS-exposed mice

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