[Retracted] Prognostic Value of Stem Cell Index‐Related Characteristics in Primary Hepatocellular Carcinoma

Abstract

The objective of this study is to form a cancer stem cell index-based model to stratify HCC risk and predict survival. After screening the Tumor Genome Atlas (TCGA) of liver and normal liver tissue samples, we obtained differentially expressed genes (DEGs). We employed a weighted correlation network analysis (WGCNA) and differentially expressed genes were studied in HCC to find the modules most associated with cancer stem cells (mRNAsi). At the same time, gene ontology and Kyoto Genome Encyclopedia (KEGG) were used for functional annotation and combined with LASSO, univariate, and multivariate COX regression analyses, a prediction model of key module genes of cancer stem cells was developed. The model’s clinical efficacy was measured using the C index, calibration curve, multiindex ROC curve, and clinical decision curve. WGCNA found that black modules were most correlated with tumour stem cell index. Seven genes (CSDC2, GNA14, LGI2, MMRN1, PDE2A, SELP, and STK32B) were filtered by univariate, LASSO, and multivariate Cox regression analyses to establish the primary HCC model. The survival analysis and ROC curve in the TCGA training and validation cohort showed good performance. The independent prognostic factor of primary HCC was risk score, according to univariate and multivariate Cox regression analyses. It is found that the stem cell index model of 7 genes could predict factors independently, indicating that signatures of the stem cell will play a significant role in liver cancer survival prediction and risk stratification.

Integrated analysis revealing a novel stemness-metabolism-related gene signature for predicting prognosis and immunotherapy response in hepatocellular carcinoma

“…The expression of PDE2A is tissue-specific and PDE2A is widely expressed in the brain and liver ( 78 ). PDE2A was demonstrated to correlate with tumorigenesis in osteosarcoma ( 82 ) and colorectal cancer ( 83 ) and to correlate with cancer stem cell stemness in glioma ( 84 ) and HCC ( 85 ). A recent study revealed that overexpressed PDE2A was associated with serum AFP level, vascular invasion, histologic grade, and pathologic stage, closely participating in inhibiting HCC cell proliferation, migration, and immune function, which had the potential to be used as a biomarker for HCC prognosis ( 81 ), the results of which consisted with our results.…”

YANK2 activated by Fyn promotes glioma tumorigenesis via the mTOR-independent p70S6K activation pathway

“…It has been reported that YANK2 is associated with various neurological diseases, such as anxiety, essential tremor, primary tremor and Parkinson's disease [6][7][8] . Recently, it has been found that YANK2 is associated with the prognosis of oral squamous cell carcinoma and primary hepatocellular carcinoma [9][10][11] . However, the function and mechanism of YANK2 in glioma remain unclear.…”

Retracted: Prognostic Value of Stem Cell Index-Related Characteristics in Primary Hepatocellular Carcinoma

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Peer-review manipulation …”

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”