YANK2 activated by Fyn promotes glioma tumorigenesis via the mTOR-independent p70S6K activation pathway
Yue Shi,
Yue Cheng,
Wei Wang
et al.
Abstract:Glioma, particularly glioblastomas (GBM), is incurable brain tumor. The most targeted receptor tyrosine kinase (RTKs) drugs did not bring benefit to GBM patients. The mechanism of glioma growth continues to be explored to find more effective treatment. Here, we reported that Ser/Thr protein kinase YANK2 (yet another kinase 2) is upregulated in glioma tissues and promotes the growth and proliferation of glioma in vitro and in vivo. Further, we confirmed that oncogene Fyn directly activated YANK2 through phospho… Show more
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