Prognostic value of pretreatment albumin&amp;ndash;globulin ratio in predicting long-term mortality in gastric cancer patients  who underwent D2 resection

Li, Jianjun; Chen, Shangxiang; Geng, Qing; Liu, Xuechao; Kong, Pengfei; Zhan, Youqing; Xu, Dazhi

doi:10.2147/ott.s99282

Cited by 33 publications

(27 citation statements)

References 32 publications

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“…However, its role in cancer suppression has not yet been well investigated. In Liu et al’s study, no relationship was found between baseline GLOB level and OS in patients with gastric cancer. In this study, K‐M survival analysis in both its test and validation sets showed little association between baseline GLOB and OS.…”

Section: Discussioncontrasting

confidence: 66%

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Pretreatment values of bilirubin and albumin are not prognostic predictors in patients with advanced pancreatic cancer

Feng

Wang

et al. 2018

Cancer Medicine

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PurposeTo identify the pretreatment values of bilirubin and albumin and other serum biomarkers in predicting the prognosis for advanced pancreatic cancer.MethodsA total of 201 consecutive patients pathologically diagnosed as advanced pancreatic cancer were retrospectively reviewed. Tumor location, TNM classification, the level of baseline total bilirubin (TBIT), direct bilirubin (DBIT), albumin (ALB), globulin (GLOB), total protein (TP), ALB to GLOB ratio (AGR), CA19‐9, CA242, and CA50 were collected. The values of CA19‐9, CA242, and CA50 were divided into two groups according to the upper limit value which were 1000 U/mL, 150 IU/mL, and 500 IU/mL, respectively. The values of TBIL, DBIL, IBIL, ALB, GLOB, TP, ALB, and GLOB were divided into low and high groups according to the median. To investigate if the median was an effective discriminator in dividing these markers, the patients were divided into a test set (n = 100) and a validation set (n = 101). Kaplan‐Meier (K‐M) survival analysis and Cox regression analysis were performed to explore the potential relationship between them and overall survival (OS).ResultsA K‐M survival analysis revealed that the investigated markers in test set, including TBIL, DBIL, IBIL, ALB, GLOB, TP, ALB, and GLOB, were not associated with the OS. The findings from the validation set were consistent with those in the test set. Factors with P value smaller than 0.1 in the univariate analysis along with the tumor location, CA19‐9, CA242, CA50, were entered into the multivariate analysis. A Cox regression analysis suggested that the cancerization at head of pancreas (P = 0.01) and a high level of CA19‐9 (P = 0.02) were independent prognostic indicators for poor OS of pancreatic cancer.ConclusionsBaseline bilirubin and serum proteins were not associated with the prognosis of advanced pancreatic cancer. Tumor location and level of CA19‐9 may serve as significant indicators for poor prognosis in those patients.

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Section: Discussioncontrasting

confidence: 66%

“…In addition to ALB and GLOB, the level of AGR was also analyzed. It has been reported that a low level of AGR has the potential to be a predictor for poor prognosis for breast cancer, gastric cancer, colorectal cancer, and lung cancer . However, in this study, the median of AGR was 1.5 (ranging from 0.6 to 2.3).…”

Section: Discussioncontrasting

confidence: 66%

Pretreatment values of bilirubin and albumin are not prognostic predictors in patients with advanced pancreatic cancer

Feng

Wang

et al. 2018

Cancer Medicine

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“…To overcome this defect, numerous recent studies have tried to investigate the prognostic significance of the albumin/globulin ratio (AGR) in cancer patients, which combines two factors and thus might reduce the influence of confounding factors. For instance, a body of studies reported that a low pretreatment AGR is closely associated with worse prognosis in patients with digestive system cancers, such as gastric cancer[ 9 , 10 ], colorectal cancer [ 11 – 15 ], pancreatic cancer[ 16 ], hepatocellular carcinoma[ 17 ] and so on. However, most studies published to date use a small sample size, which might affect the reliability of their conclusions.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of pretreatment albumin/globulin ratio in digestive system cancers: A meta-analysis

Guo¹,

Yuan²,

Chen³

et al. 2018

PLoS ONE

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The albumin/globulin ratio (AGR) has been widely reported to be a potential predictor of prognosis in digestive system cancers (DSCs), but convincing conclusions have not been made. Therefore, herein, we performed a meta-analysis of relevant studies regarding this topic to evaluate the prognostic value of AGR in patients with DSCs. Three databases, including PubMed, EMBase, and Web of science, were searched comprehensively for eligible studies through September 8, 2017. The outcomes of interest included overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS). In our meta-analysis, pooled analysis of 13 studies with 9269 patients showed that a low AGR was significantly correlated with poor OS (HR = 1.94; 95% CI: 1.57–2.38; P <0.001). Five studies with 6538 participants involved DFS, and our pooled analysis of these studies also demonstrated that there was a significant association of a low AGR with worse DFS (HR = 1.49; 95% CI: 1.10 to 2.00; P < 0.001). In addition, only 2 studies referred to CSS, and we also detected a significant relationship between a low AGR and worse CSS from the results of our meta-analysis. In summary, a low pretreatment AGR was related to unfavorable survival in human digestive system cancers. A low pretreatment AGR may be a useful predictive prognostic biomarker in human digestive system cancers.

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“…Approximately 40% of all GC cases occur in China and these are often diagnosed in the advanced stages [ 3 , 4 ]. The 5 year survival rate was 28% in 2014 [ 5 ]. Many factors result in the occurrence of GC, including genetic and epigenetic alterations.…”

Section: Introductionmentioning

confidence: 99%

Sorcin induces gastric cancer cell migration and invasion contributing to STAT3 activation

et al. 2017

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Gastric cancer (GC) is a globally occurring malignancy that is characterized by a high mortality rate due to a high tendency to metastasize and poor prognoses. Sorcin, as known as SRI, a soluble resistance-related calcium-binding protein, plays a significant role in multidrug resistance. Sorcin is related to the migration and invasion of cancer cells. However, the mechanism remains unclear. Here, we used immunohistochemistry to confirm that the expression of sorcin in cancer tissues is higher than that in the adjacent normal tissues. The wound healing and transwell results indicate that sorcin can induce migration and invasion of GC cells. To explore the role of sorcin in GC metastasis, isobaric tags for relative and absolutely quantitation (iTRAQ) were used to examine cells with and without sorcin knockdown to identify the differentially expressed proteins (DEPs). The results were evaluated via RT-PCR and western blot to confirm the ITRAQ data. Inhibition of sorcin expression can down- regulate the expression of CTSZ, MMP2, MMP9 and p-STAT3 followed by suppression of tumor growth and metastasis. Together, we concluded that sorcin has a oncogenic activity via inducing tumor growth and metastasis, leading to development of therapeutic treatments for GC.

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Prognostic value of pretreatment albumin–globulin ratio in predicting long-term mortality in gastric cancer patients who underwent D2 resection

Cited by 33 publications

References 32 publications

Pretreatment values of bilirubin and albumin are not prognostic predictors in patients with advanced pancreatic cancer

Pretreatment values of bilirubin and albumin are not prognostic predictors in patients with advanced pancreatic cancer

Prognostic value of pretreatment albumin/globulin ratio in digestive system cancers: A meta-analysis

Sorcin induces gastric cancer cell migration and invasion contributing to STAT3 activation

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