Prognostic value of preoperative serum cea level compared to clinical staging IV. Histological grading and tumor type in colorectal and gastric cancer

Abstract

In a clinical investigation of observed postoperative survival, 410 patients with colorectal cancer and 269 patients with stomach cancer have been registered for primary surgical treatment connected with a long-term follow up. Histologic grading and tumor typing were examined as potential prognostic factors and compared with the prognostic information covered by operability, tumor extension, and the preoperative CEA level. Statistical treatment of the data revealed no prognostic significance of the tumor types adenocarcinoma, mucinous, and anaplastic tumours in gastric cancer. Histologic grading specified ranges associated with significant differences in survival of gastric and colorectal cancer patients. However, histologic grading did not provide prognostic information in addition to operability and tumor extension. However, histologic grading gave additional prognostic information to preoperative CEA levels in the range of 0-5 micrograms CEA/1 serum but not in the range greater than 5 micrograms CEA/1. The results indicate that the prognostic information of preoperative serum CEA level is not directly linked to the histologic grade of a tumor.

The prognostic significance of preoperative serum CA 19‐9 in patients with resectable gastric carcinoma: comparison with CEA

“…Consistent with the Kodera et al study [6], differentiated tumors in our series tended to show a higher rate in CEA positive patients; however, the difference was not statistically signi®cant. Other investigators found no correlation between CEA and histologic type [13,16,19]. The differences between reports addressing histologic type and these tumor markers may be due to the variation of histologic types in differentiated and undifferentiated tumor groups and the different rates of these histologic types in different series.…”

The Prognostic Significance of Pretreatment Serum CEA Levels in Gastric Cancer: A Meta-Analysis Including 14651 Patients

“…HRs and 95% CIs were available in 19 studies[38,39,40,24,41,13,25,42,20,43,21,44,45,46,47,37,48,49,50]. In the remaining studies, the values were extracted from the published survival curves in 14 studies[51,35,52,12,53,54,55,56,17,11,16,57,23,58], and estimated from the variance and its P -value (the Log-rank test) from one study[36] using the statistical methods previously reported[26]. The pooled HR and 95% CI values of these 34 studies were estimated (HR 1.786, 95% CI 1.550–2.060), but significant heterogeneity was observed among these studies with respect to OS ( I 2 = 77.7%, n = 34, P < 0.001: Table 2).…”