The Prognostic Significance of Pretreatment Serum CEA Levels in Gastric Cancer: A Meta-Analysis Including 14651 Patients

Deng, Kai; Yang, Li; Hu, Bing; Wu, Hao; Zhu, Hong; Tang, Chengwei

doi:10.1371/journal.pone.0124151

Cited by 89 publications

(78 citation statements)

References 57 publications

(153 reference statements)

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“…Several of the most frequently used tumor markers, including carbohydrate antigen (CA)724, CA199, carcinoembryonic antigen (CEA) and CA242, have been confirmed to jointly provide information aiding in the diagnosis, classification, prognosis and treatment selection in gastric cancer (18)(19)(20)(21), while the value of information provided by of any of them alone is low. Jing et al (22) found that the sensitivity of CA724, CA199, CEA and CA242 was only 25.4, 36.2, 26.8 and 42.9%, respectively.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of serum tumor abnormal protein in gastric cancer patients

Feng

Zhu

et al. 2016

Molecular and Clinical Oncology

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Abstract. Aberrant glycosylation of protein occurs in nearly all types of cancers and has been confirmed to be associated with tumor progression, metastasis and the survival rate of patients. The present study aimed to explore the prognostic value of tumor abnormal protein (TAP) in gastric cancer patients. TAP was detected in the blood of 42 gastric cancer patients and 56 healthy volunteers by using the TAP testing kit. Univariate and multivariate Cox regression analysis were performed to evaluate the prognostic value of TAP. In total, 64.3% of gastric cancer patients were positive for TAP, and TAP was significantly correlated with poor prognosis [progression-free survival (PFS), 4.2 vs. 12.6 months; P= 0.043]. TAP [hazard ratio (HR), 64.487; P<0.01), differentiation (HR, 17.279; P<0.01) and TNM stage (HR, 45.480; P<0.01) were found to be independent predictive factors for PFS. Furthermore, Kaplan-Meier curves indicated that TAP is associated with a reduced PFS in gastric cancer patients. The results of the present study therefore indicated that the TAP test has significant prognostic value for gastric cancer patients.

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Section: Discussionmentioning

confidence: 99%

Prognostic value of serum tumor abnormal protein in gastric cancer patients

Feng

Zhu

et al. 2016

Molecular and Clinical Oncology

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“…Whether serum CEA and CA19-9 levels contribute as prognostic indicators for patients with GC has long been discussed, but the results have been rather mixed [10,11]. Inconsistencies in the criteria used for patient inclusion and analyses and different variables (e.g., early detection or prognostic factors) are cited as possible explanations of the conflicting data [12][13][14]. In addition, advances in measurement technology, increased prevalence of early-stage GC, and changes in standard of care such as application of adjuvant therapies may also have caused changes in the clinical significance of serum CEA and CA19-9 over time [15][16][17].…”

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confidence: 99%

Perioperative Serum Carcinoembryonic Antigen Levels Predict Recurrence and Survival of Patients with Pathological T2-4 Gastric Cancer Treated with Curative Gastrectomy

et al. 2017

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Background/Aims: Do serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 levels serve as prognostic indicators in patients with gastric cancer (GC)? This is a question that has long been disputed. The aim of this study was to evaluate the significance of perioperative serum levels of CEA and CA19-9 for predicting the recurrence and long-term survival after patients with pT2-4 GC undergo curative gastrectomy. Methods: This study included 251 patients with radically resected pT2-4 GC without preoperative treatment. Associations between the preoperative and postoperative serum levels of CEA or CA19-9 and postoperative long-term outcomes and recurrence patterns were evaluated. Results: Preoperative CEA >5.0 ng/mL was an independent prognostic factor of overall survival. Elevation of both preoperative CEA and CA19-9 levels showed no synergistic adverse effects on prognosis. Preoperative levels of these markers achieved superior predictive performance compared with the postoperative values. Adverse prognosis is significantly associated with persistent elevation of CEA levels before and after gastrectomy. Elevation of CEA levels, particularly at postoperative measurement, was significantly associated with hematogenous recurrence. Conclusion: Determination of perioperative CEA levels facilitated predictions of recurrence patterns and prognosis among patients with pT2-4 GC who underwent curative gastrectomy.

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“…They found increased CEA levels about 4.8 months before the clinical detection of cancer recurrence in 4 of 13 patients with GC recurrence. A recent meta-analysis by Deng et al [75] confirmed the association of elevated pretreatment serum CEA levels with a poor prognosis for GC and a nearly doubled risk of mortality in GC patients (Table 1). The authors concluded that serum CEA may serve as an independent prognostic factor for patients with GC and that CEA could facilitate therapeutic decisions in CEA-positive patients.…”

Section: Cea In Gcmentioning

confidence: 89%

Carbohydrate Antigen 19-9, Carcinoembryonic Antigen, and Carbohydrate Antigen 72-4 in Gastric Cancer: Is the Old Band Still Playing?

Kotzev¹,

Draganov

2018

Gastrointest Tumors

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Background: Gastric cancer (GC) is characterized by aggressive behavior and a high mortality rate. The diagnosis of GC is challenging because the GC is often diagnosed in an advanced stage. The use of tumor markers is a putative way to improve the detection and treatment in patients with GC. Summary: In this article, we review the significance of serum carbohydrate antigen (CA) 19-9, carcinoembryonic antigen (CEA), and CA 72-4 in GC. The results from different studies regarding the diagnostic and prognostic role of CA 19-9, CEA, and CA 72-4 in GC are encouraging, but inadequate sensitivity and specificity obstruct their use as standardized and unconditionally reliable markers in GC. New prospective clinical trials are mandatory for clarifying their value in GC. Key Message: CA 19-9, CEA, and CA 72-4 should not be used for screening and early diagnosis in GC, whereas they are beneficial in the detection of late GC. CA 19-9, CEA, and CA 72-4 could be used as prognostic and monitoring tools in GC, and their combined measurement in shorter periods of time is the best method to increase sensitivity and specificity. Practical Implications: Serum CA 19-9, CEA, and CA 72-4 are useful diagnostic and prognostic tumor markers in GC.

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The Prognostic Significance of Pretreatment Serum CEA Levels in Gastric Cancer: A Meta-Analysis Including 14651 Patients

Cited by 89 publications

References 57 publications

Prognostic value of serum tumor abnormal protein in gastric cancer patients

Prognostic value of serum tumor abnormal protein in gastric cancer patients

Perioperative Serum Carcinoembryonic Antigen Levels Predict Recurrence and Survival of Patients with Pathological T2-4 Gastric Cancer Treated with Curative Gastrectomy

Carbohydrate Antigen 19-9, Carcinoembryonic Antigen, and Carbohydrate Antigen 72-4 in Gastric Cancer: Is the Old Band Still Playing?

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