Prognostic value of pre-treatment circulating monocyte count in patients with cervical cancer: Comparison with SCC-Ag level

Lee, Yoo-Young; Choi, Chel Hun; Sung, Chang Ohk; Do, In‐Gu; Huh, So-Young; Song, Taejong; Kim, Min Kyu; Kim, Ha-Jeong; Kim, Tae-Joong; Lee, Jeong‐Won; Kim, Byoung-Gie; Bae, Duk-Soo

doi:10.1016/j.ygyno.2011.09.034

Cited by 91 publications

(86 citation statements)

References 31 publications

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“…Our findings is completely consistent with previously reported studies which demonstrated that increased AMC predicted inferior survival in early-stage HCC, nasopharyngeal carcinoma and cervical cancer (Sasaki et al, 2006;Lee et al, 2012;Li et al, 2013). Currently, although growing evidence clearly confirms the prognostic significance of AMC in the above-mentioned malignancies, the exact mechanism for the interaction between monocytes and HCC is not yet fully addressed.…”

Section: Resultssupporting

confidence: 92%

“…As an example, high level of peripheral blood inflammatory biomarkers including C-reactive protein and neutrophil-to-lymphocyte ratio was reported to be associated with inferior prognosis in patients with a variety of malignancies (Zheng et al, 2013;Yu et al, 2013;Jin et al, 2014). Likewise, a large number of studies have revealed that peripheral blood absolute monocyte count (AMC) is considered as an independent prognostic factor in a range of malignancies, including early-stage HCC undergoing curative resection (Sasaki A et al, 2006;Lee et al, 2012;Huang et al, 2013;Li et al, 2013). To date, the prognostic significance of circulating AMC in patients with advanced HCC is still uncertain.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic Significance of the Peripheral Blood Absolute Monocyte Count in Patients with Locally Advanced or Metastatic Hepatocellular Carcinoma Receiving Systemic Chemotherapy

Lin

Jiang²,

Peng³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Prognostic Significance of the Peripheral Blood Absolute Monocyte Count in Patients with Locally Advanced or Metastatic Hepatocellular Carcinoma Receiving Systemic Chemotherapy

Lin

Jiang²,

Peng³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…A correlation between monocytosis and poor prognosis in different types of cancer has previously been observed (16,(25)(26)(27). Monocytes represent a source of chemokines and cytokines that contribute to inflammation (28).…”

Section: Univariate Analysis Multivariate Analysis ------------------mentioning

confidence: 88%

Prognostic significance of the preoperative lymphocyte-to-monocyte ratio in patients with colorectal cancer

et al. 2016

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Abstract.A correlation between the lymphocyte-to-monocyte ratio (LMR) and the survival of patients with hematological malignancies has been reported previously. However, there have been few studies investigating the prognostic significance of LMR in patients with solid tumors. The aim of the present study was to evaluate the prognostic significance of preoperative LMR in patients with colorectal cancer (CRC). A total of 189 patients undergoing potentially curative surgery for CRC were enrolled. The LMR was calculated from preoperative blood samples by dividing absolute lymphocyte count by absolute monocyte count. A cut-off value of 4.8 was set based on the receiver operating characteristic curve; 116 patients were classified as high-LMR, and 73 patients classified as low-LMR. The high-LMR group exhibited significantly better relapse-free survival (P=0.0018) and overall survival (P=0.0127) rates than the low-LMR group. According to the multivariate analysis of survival, preoperative LMR was identified as an independent prognostic factor for relapse-free survival (P=0.041) and overall survival (P=0.031). Therefore, preoperative LMR is a useful prognostic marker in patients with CRC. IntroductionColorectal cancer (CRC) is the third most common cancer and fourth leading cause of cancer-associated mortality worldwide (1). Despite advances in surgical procedures and adjuvant chemotherapy, 20-25% of patients still experience relapse following curative surgery (2). The Union for International Cancer Control (UICC) tumor node metastasis (TNM) staging system (3) is currently the most reliable indicator of patient prognosis and is widely used amongst practitioners. However, there are differences in patient prognosis even within the same TNM stage. Therefore, more reliable markers are required to improve predictions of cancer recurrence and patient survival.It has previously been reported that inflammation is important in determining cancer progression (4,5). Inflammation-based indices, such as the C-reactive protein level, Glasgow prognostic score, and neutrophil-to-lymphocyte ratio; are useful for predicting the prognosis of patients with CRC as well as various other types of cancer (6-9). Recent studies investigating various types of malignancies have demonstrated a correlation between the lymphocyte-to-monocyte ratio (LMR), which also reflects the degree of systemic inflammation, and patient survival (10-14). However, the prognostic value of the LMR has mainly been investigated in patients with hematological malignancies, with few reports focusing on patients with solid tumors. Therefore, the aim of this retrospective study was to evaluate the prognostic significance of preoperative LMR in patients with CRC who are able to undergo potentially curative surgery. Materials and methods Patients.A total of 189 patients with CRC were enrolled. All patients underwent potentially curative surgery for CRC in the Department of Surgical Oncology, Osaka City University, between January 2007 and December 2009. Patients who received ...

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“…Patients with endometrial cancer have significantly higher monocyte counts in pretreatment blood samples compared to healthy non-cancer controls [26]. In other types of gynecologic malignancy, an elevated circulating monocyte count was associated with decreased survival in both ovarian and cervical cancers [27,28]. However, to date, no study has reported the impact of monocyte counts on endometrial cancer survival.…”

Section: Discussionmentioning

confidence: 99%

Significance of monocyte counts on tumor characteristics and survival outcome of women with endometrial cancer

Matsuo

Hom

Moeini

et al. 2015

Gynecologic Oncology

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Prognostic value of pre-treatment circulating monocyte count in patients with cervical cancer: Comparison with SCC-Ag level

Cited by 91 publications

References 31 publications

Prognostic Significance of the Peripheral Blood Absolute Monocyte Count in Patients with Locally Advanced or Metastatic Hepatocellular Carcinoma Receiving Systemic Chemotherapy

Prognostic Significance of the Peripheral Blood Absolute Monocyte Count in Patients with Locally Advanced or Metastatic Hepatocellular Carcinoma Receiving Systemic Chemotherapy

Prognostic significance of the preoperative lymphocyte-to-monocyte ratio in patients with colorectal cancer

Significance of monocyte counts on tumor characteristics and survival outcome of women with endometrial cancer

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