Significance of monocyte counts on tumor characteristics and survival outcome of women with endometrial cancer

Matsuo, Koji; Hom, Marianne S.; Moeini, Aida; Machida, Hiroko; Takeshima, Nobuhiro; Roman, Lynda D.; Sood, Anil K.

doi:10.1016/j.ygyno.2015.05.019

Cited by 35 publications

(27 citation statements)

References 33 publications

(41 reference statements)

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“…The STROBE guidelines were consulted for reporting in a case-control study [4]. Some of the patients in this study were within the context of our previous studies [20][21][22][23][24].…”

Section: Materials and Methods Eligibilitymentioning

confidence: 99%

Impact of depth and extent of lymphovascular space invasion on lymph node metastasis and recurrence patterns in endometrial cancer

Matsuo

Garcia‐Sayre

Medeiros

et al. 2015

Journal of Surgical Oncology

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“…The STROBE guidelines were consulted for reporting in a case-control study [4]. Some of the patients in this study were within the context of our previous studies [20][21][22][23][24].…”

Section: Materials and Methods Eligibilitymentioning

confidence: 99%

Impact of depth and extent of lymphovascular space invasion on lymph node metastasis and recurrence patterns in endometrial cancer

Matsuo

Garcia‐Sayre

Medeiros

et al. 2015

Journal of Surgical Oncology

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“…Similar to our findings in mCRC, elevated preoperative monocytes correlates with a poor prognosis in several human cancers. 15,24,25 Furthermore, neoplastic expression of CCL2 correlates with increased TAM infiltrate and worse prognosis in multiple solid tumors. 16,17,26 Likewise, a high TAM density correlates with decreased survival in breast, pancreatic, liver, and other tumors.…”

Section: Discussionmentioning

confidence: 99%

Recruitment of CCR2⁺tumor associated macrophage to sites of liver metastasis confers a poor prognosis in human colorectal cancer

et al. 2018

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The tumor microenvironment (TME) represents a significant barrier to creating effective therapies for metastatic colorectal cancer (mCRC). In several malignancies, bone marrow derived CCR2 inflammatory monocytes (IM) are recruited to the TME by neoplastic cells, where they become immunosuppressive tumor associated macrophages (TAM). Here we report that mCRC expression of the chemokine CCL2 facilitates recruitment of CCR2 IM from the bone marrow to the peripheral blood. Immune monitoring of circulating monocytes in patients with mCRC found this influx was a prognostic biomarker and correlated with worse clinical outcomes. At the metastatic site, mCRC liver tumors were heavily infiltrated by TAM, which displayed a robust ability to dampen endogenous anti-tumor lymphocyte activity. Using a murine model of mCRC that recapitulates these findings from human disease, we show that targeting CCR2 reduces TAM accumulation in liver metastasis and restores anti-tumor immunity. Additional quantitative analysis of hepatic metastatic tumor burden and treatment efficacy found that administration of a small molecule CCR2 inhibitor (CCR2i) improves chemotherapeutic responses and increases overall survival in mice with mCRC liver tumors. Our study suggests that targeting the CCL2/CCR2 chemokine axis decreases TAM at the metastatic site, disrupting the immunosuppressive TME and rendering mCRC susceptible to anti-tumor T-cell responses.

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“…11,12 In addition, an increased number of circulating monocytes have been associated with aggressive tumor behavior and decreased survival in women with endometrial cancer. 13 However, the significance of monocyte levels at recurrence/progression remains unclear in the setting of endometrial cancer. The aim of this study was to examine the association between monocyte counts at the first recurrence/progression and SAR in women with endometrial cancer.…”

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confidence: 99%

Significance of Monocyte Counts at Recurrence on Survival Outcome of Women With Endometrial Cancer

Machida

Zoysa

Takiuchi

et al. 2017

Int J Gynecol Cancer

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Significance of monocyte counts on tumor characteristics and survival outcome of women with endometrial cancer

Abstract: Elevated monocyte counts were associated with aggressive tumor features and poor survival outcomes of patients with endometrial cancer.

Cited by 35 publications

References 33 publications

Impact of depth and extent of lymphovascular space invasion on lymph node metastasis and recurrence patterns in endometrial cancer

Impact of depth and extent of lymphovascular space invasion on lymph node metastasis and recurrence patterns in endometrial cancer

Recruitment of CCR2⁺tumor associated macrophage to sites of liver metastasis confers a poor prognosis in human colorectal cancer

Significance of Monocyte Counts at Recurrence on Survival Outcome of Women With Endometrial Cancer

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Significance of monocyte counts on tumor characteristics and survival outcome of women with endometrial cancer

Abstract: Elevated monocyte counts were associated with aggressive tumor features and poor survival outcomes of patients with endometrial cancer.

Cited by 35 publications

References 33 publications

Impact of depth and extent of lymphovascular space invasion on lymph node metastasis and recurrence patterns in endometrial cancer

Impact of depth and extent of lymphovascular space invasion on lymph node metastasis and recurrence patterns in endometrial cancer

Recruitment of CCR2+tumor associated macrophage to sites of liver metastasis confers a poor prognosis in human colorectal cancer

Significance of Monocyte Counts at Recurrence on Survival Outcome of Women With Endometrial Cancer

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Recruitment of CCR2⁺tumor associated macrophage to sites of liver metastasis confers a poor prognosis in human colorectal cancer