Prognostic Value of P63, Maspin, and MMP-2 Expression in Salivary Gland Adenoid Cystic Carcinoma

Taghavi, Nasim; Khozestani, Parisa Kardouni; Yazdani, Farzad; Baghban, Alireza Akbarzadeh

doi:10.5812/ijcm.7564

Cited by 2 publications

(1 citation statement)

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“…When the histological picture of MC contains the typical cytomorphology of islands of bi-layered epithelium with oncocytic and basal cells, squamous cells showing atypical nuclei, and necrotic stroma, the diagnosis is often straightforward. However, in most cases, these typical features are unclear, which necessitates the use of other techniques such as immunohistochemistry, CT imaging [ 77 ], and molecular profiling to reach a definitive diagnosis [ 81 ]. All other neoplasms in the differential diagnosis of SACC require a comprehensive diagnostic approach using clinical assessment, histopathology, imaging, immunohistochemistry, and molecular profiling to reach an accurate diagnosis, which is often challenging and requires a multidisciplinary approach.…”

Section: Resultsmentioning

confidence: 99%

Adenoid Cystic Carcinoma of Salivary Glands: A Ten-Year Review and an Assessment of the Current Management, Surgery, Radiotherapy, and Chemotherapy

Saleh

Ukwas

2023

International Journal of Otolaryngology

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Adenoid cystic carcinoma (ACC) is a rare cancer that arises from the salivary glands and other sites in the body, such as the lung and breast. Although the tumor accounts for 10% of all salivary gland malignancies, it only accounts for 1% of head and neck malignancies. It can affect both major and minor salivary glands; here, it is called salivary gland adenoid cystic carcinoma or SACC, with a slight predilection to the latter, and commonly manifests between the 6th and 7th decades of life. The disease also shows a slight female predilection, with a reported female to male ratio of 3 : 2. Lesions of SACC are often insidious and slow-growing, and symptoms such as pain and altered sensation are frequently associated with advanced stages of the disease. Salivary adenoid cystic carcinoma is characterized by perineural invasion (PNI), a distinctive feature that potentially plays a significant role in the tumor’s relapse and recurrence, which is approximately 50%. The disease is not prevalent, and its etiopathogenesis is poorly understood, although several genetic patterns and biomarkers have been linked to its initiation and/or progression. The discovery of these mutations and biomarkers has encouraged several clinical studies to use therapeutic agents to target the specific receptors on the cancer cells to potentially prevent further proliferation of the tumor cells and metastasis of the disease. Diagnosis of SACC is often challenging and frequently requires a combination of clinical examination, imaging, and histopathology. Management of SACC is primarily surgical excision, while radiotherapy has shown to be effective in improving local control in cases with microscopic residual disease. However, treatment of recurrent or metastatic tumors by radiotherapy with or without chemotherapy has so far shown limited success. The aim of this thesis is to provide an update of literature on SACC with a particular focus on the latest management approaches and future trends.

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Section: Resultsmentioning

confidence: 99%