Prognostic value of p16 expression irrespective of human papillomavirus status in patients with oropharyngeal carcinoma

Saito, Yuki; Yoshida, Masafumi; Omura, Go; Kobayashi, Kenya; Fujimoto, Chisato; Ando, Mizuo; Sakamoto, Takashi; Asakage, Takahiro; Yamasoba, Tatsuya

doi:10.1093/jjco/hyv085

Cited by 25 publications

(33 citation statements)

References 26 publications

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“…Positive effect of p16 positivity on prognosis and treatment outcomes has been repeatedly reported, and our study also demonstrated significantly better OS and PFS rates associated with p16 positivity and marginal significance in term of LRC. In p16 IHC, we have used the current accepted consensual approach.…”

Section: Discussionsupporting

confidence: 81%

Prognostic impact of combined immunoprofiles in oropharyngeal squamous cell carcinoma patients with respect to AJCC 8th edition

Gurín

Slavík

Hermanová

et al. 2018

J Oral Pathology Medicine

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Section: Discussionsupporting

confidence: 81%

Prognostic impact of combined immunoprofiles in oropharyngeal squamous cell carcinoma patients with respect to AJCC 8th edition

Gurín

Slavík

Hermanová

et al. 2018

J Oral Pathology Medicine

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“…Importantly, ISH-HPV negativity cannot exclude HPV-positive or “passenger” HPV lesions because the HPV DNA load might be below the threshold of ISH-HPV detection. However, because we have reported that the agreement rate of ISH-HPV and PCR-E6 is 74% [11], we considered that ISH-HPV negativity in 7 cases with p16 positivity indicated that HPV scarcely affected the carcinogenesis of NPC in our cohort.…”

Section: Discussionmentioning

confidence: 99%

“…The p16 immunohistochemistry was considered positive if strong diffuse staining was noted in the nuclei and cytoplasm of more than 70% of the malignant cells (Fig. 1a), as previously described [11]. …”

Section: Methodsmentioning

confidence: 99%

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Clinical Value of the Epstein-Barr Virus and p16 Status in Patients with Nasopharyngeal Carcinoma: A Single-Centre Study in Japan

Saito

Ushiku

Omura

et al. 2016

ORL

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Background: The clinical significance of the Epstein-Barr virus (EBV) status and p16 expression was unknown in nasopharyngeal carcinoma (NPC). Methods: We retrospectively studied our pathology database for 13 years to determine the prevalence of EBV and p16 expression and their association with prognosis in cases of NPC. We performed immunohistochemistry for the p16 protein and in situ hybridization (ISH) for EBV-encoded small RNAs and human papillomavirus (HPV) DNA. Results: Of the 43 patients with NPC, 27 (63%), 6 (14%), and 10 (23%) cases were EBV positive, EBV negative with keratinization, and EBV negative without keratinization, respectively. No cases were HPV positive by ISH. Among the 21 EBV-positive tumours that were tested for p16, only 2 tumours were p16 positive. The keratinization-positive group included only males, typically >60 years of age (5 of 6) and with T4 tumours (3 of 6). In contrast, the EBV-positive cohort tended to be younger (<60 years, 13 of 27) and have progressive N-stage tumours (N2-3, 14 of 27). The keratinization and EBV-negative cohort included predominantly males (9 of 10) who were likely p16 negative (4 of 10) and smokers (7 of 10). Multivariate analysis confirmed that keratinization was an independent prognostic factor for progression-free survival. Conclusion: In areas, such as Japan, that are nonendemic for both EBV and HPV, the causality of NPC appears to be more heterogeneous.

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“…Renal function was assessed as normal if the creatinine clearance was ≥ 60 mL/min). Formalin‐fixed paraffin‐embedded pretreatment biopsies were retrieved from the records of our pathology department, and p16 positivity was substituted for HPV positivity …”

Section: Methodsmentioning

confidence: 99%

Induction Chemotherapy for p16 Positive Oropharyngeal Squamous Cell Carcinoma

Saito¹,

Ando²,

Omura³

et al. 2016

Laryngoscope Investig Oto

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Objectives/HypothesisWe aimed to determine the effectiveness of induction chemotherapy for treating p16‐positive oropharyngeal cancer in our department.Study DesignThis was a retrospective case series to assess treatment effectiveness.MethodsWe administered induction chemotherapy to patients with stage III to IV oropharyngeal p16‐positive squamous cell carcinoma between 2008 and 2013. Induction chemotherapy was administered using combinations of docetaxel, cisplatin, and 5‐fluorouracil. We measured the survival rates using the Kaplan‐Meier method and log‐rank test.ResultsWe reviewed 23 patients (18 men and 5 women; age, 42–79 years). Induction chemotherapy resulted in partial or complete remission (20 patients) and in stable (2 patients) or progressive (1 patient) disease. In partial or complete remission, subsequent radiotherapy was performed in 16 patients, chemoradiotherapy in two, and transoral resection in two. In stable or progressive disease, subsequent open surgery was performed. Overall, one patient died of cervical lymph node metastasis, one died of kidney cancer, and one died of myocardial infarction. Event‐free, distant‐metastasis–free survival was present for 20 patients. The 3‐year disease‐specific survival was 95%; the overall survival was 87%. Two patients required gastrostomies during chemoradiotherapy and three required tracheotomies, but these were closed in all patients.ConclusionThe therapeutic response to induction chemotherapy for p16‐positive oropharyngeal cancer was good. Partial or complete remission was achieved in almost 90% patients, and control of local and distant metastases was possible when it was followed by radiotherapy alone or with transoral resection of the primary tumor. A multicenter study is required to confirm these findings.Level of Evidence4.

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Prognostic value of p16 expression irrespective of human papillomavirus status in patients with oropharyngeal carcinoma

Abstract: p16 expression was a reliable prognostic biomarker regardless of human papillomavirus status.

Cited by 25 publications

References 26 publications

Prognostic impact of combined immunoprofiles in oropharyngeal squamous cell carcinoma patients with respect to AJCC 8th edition

Prognostic impact of combined immunoprofiles in oropharyngeal squamous cell carcinoma patients with respect to AJCC 8th edition

Clinical Value of the Epstein-Barr Virus and p16 Status in Patients with Nasopharyngeal Carcinoma: A Single-Centre Study in Japan

Induction Chemotherapy for p16 Positive Oropharyngeal Squamous Cell Carcinoma

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