Prognostic impact of combined immunoprofiles in oropharyngeal squamous cell carcinoma patients with respect to <scp>AJCC</scp> 8th edition

Gurín, Dominik; Slavík, M; Hermanová, Markéta; Shatokhina, Tetiana; Šána, Jiří; Kazda, Tomáš; Selingerová, Iveta; Ahmad, Parwez; Smilek, Pavel; Hořáková, Zuzana; Hendrych, Michal; Šlampa, Pavel; Slabý, Ondřej

doi:10.1111/jop.12772

Cited by 6 publications

(4 citation statements)

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“…On the other hand, recent studies have been starting to investigate the role of the HPV status, and demonstrated, for instance, that the application of the TNM 8th ed. is more suitable for HPV-mediated oropharyngeal squamous cell carcinoma (Gurin et al, 2018;Mizumachi et al, 2017). Preliminary results also showed that NLR maintained its prognostic value both in HPV-positive and non-HPV-related tumours.…”

Section: Introductionmentioning

confidence: 87%

Prognostic significance of neutrophil‐to‐lymphocyte ratio in HPV status era for oropharyngeal cancer

et al. 2020

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Aim To evaluate the role of baseline neutrophil‐to‐lymphocyte ratio (NLR) as prognostic marker in squamous cell carcinoma of the oropharynx (OPC) treated with definitive chemoradiotherapy (CRT) in the era of HPV status. Patients and methods A retrospective analysis of 125 patients (pts) affected with locally advanced OPC was performed. Inclusion criteria were age >18 years, stage III or IV (TNM 7th ed.) and definitive CRT. Haematological marker for their independent role as prognostic biomarkers for progression‐free survival (PFS) and overall survival (OS). Logistic models were used to assess the association with downstage in TNM 8th ed. Results Seventy‐seven (61.6%) pts had HPV/p16 + related OPC. Therapeutic choice consisted in sequential and concurrent CRT. Median follow‐up was 50 months. A value of NLR ≥3 was associated with poorer OS. Two‐year OS was 91% and 81% in pts with NLR <3 and ≥3, respectively. Conclusion A baseline NLR ≥ 3 at treatment initiation represented a negative prognostic marker for OPC treated with definitive CRT. These results are in line with literature data, and prognostic value of NLR has been confirmed restaging our cohort with new TNM staging (8th ed.). Therefore, NLR could be considered a valuable biomarker for risk stratification in pts with OPC.

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Section: Introductionmentioning

confidence: 87%

Prognostic significance of neutrophil‐to‐lymphocyte ratio in HPV status era for oropharyngeal cancer

et al. 2020

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“…p16, EGFR, and CD44 immunohistochemical analysis. All immunohistochemical (IHC) analyses were performed as described previously (9). Briefly, sections from the FFPE primary biopsy samples, obtained prior to the treatment, were stained with hematoxylin-eosin and were independently reviewed by two pathologists.…”

Section: Real-time Quantification Of Mirnas By Stem-loop Rt-pcrmentioning

confidence: 99%

MicroRNA-15b-5p Predicts Locoregional Relapse in Head and Neck Carcinoma Patients Treated With Intensity-modulated Radiotherapy

Ahmad

Šána

Slavík

et al. 2019

Cancer Genomics Proteomics

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“…U nádorů hlavy a krku asociovaných s kouřením hrají hlavní roli v procesu kancerogeneze mutace tumor supresorových genů TP53, které nacházíme minoritně u HPV asociovaných nádorů [23,24]. Oproti HPV asociovaným nádorům tyto navíc zvýšeně exprimují geny asociované s hypoxií a markery nádorových kmenových buněk, které zvyšují jejich radiorezistenci [25][26][27]. Bylo prokázáno, že počet mutací u HPV pozitivních nádorů je poloviční oproti HPV negativním nádorům [28].…”

Section: Molekulární Podklad Hpv Asociovaných Karcinomů Hlavy a Krkuunclassified

Current Perspective on HPV-Associated Oropharyngeal Carcinomas and the Role of p16 as a Surrogate Marker of High-Risk HPV

Gurín¹,

Slavík²,

Shatokhina³

et al. 2019

Klin Onkol

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1 I. ústav patologie, LF MU a FN u sv. Anny v Brně 2 Klinika radiační onkologie, LF MU a Masarykův onkologický ústav, Brno 3 CEITEC -Středoevropský technologický institut, MU, Brno 4 Klinika komplexní onkologické péče, LF MU a Masarykův onkologický ústav, Brno SouhrnVýchodiska: Karcinomy orofaryngu asociované s lidským papilomavirem (human papillomavirus -HPV) nejen pro svou nadále vzrůstající incidenci představují významnou kapitolu v oblasti nádorů hlavy a krku. Tyto nádory oproti HPV negativním karcinomům orofaryngu disponují odlišnými epidemiologickými, klinickými i molekulárními vlastnostmi, lepší odpovědí na léčbu a prognózou. Vlivem těchto skutečností byla provedena celá řada studií, jejichž společným cílem bylo navržení adekvátního stagingového systému pro HPV asociované karcinomy orofaryngu, neboť 7. vydání American Joint Committee on Cancer nebralo v potaz unikátní bio logické chování tohoto onemocnění. Výsledkem jsou zásadní změny v TNM klasifikaci karcinomů orofaryngu, které jsou nyní v závislosti na expresi surogátního markeru high-risk HPV p16 členěny na p16 pozitivní a p16 negativní. Cíl: Cílem tohoto přehledového článku je nejen shrnutí aktuálních vědomostí o HPV asociovaných karcinomech orofaryngu s důrazem na jejich molekulární podklad a morfologii, ale také shrnutí a porovnání metod detekce viru HPV. Zároveň je diskutován prognostický význam exprese biomarkeru p16 u těchto nádorů. Součástí přehledového článku je dále představení změn ve stagingu karcinomů orofaryngu v závislosti na expresi markeru p16, vč. odůvodnění, která k těmto změnám vedla. SummaryBackground: The incidence of oropharyngeal carcinomas associated with human papillomavirus (HPV) is continuously increasing. HPV-positive and -negative oropharyngeal carcinomas have different epidemiological, clinical, and molecular features, with HPV-positive tumors having a better response to treatment and better prognosis. An adequate staging system for HPV-related oropharyngeal carcinomas is needed, as the American Joint Committee on Cancer 7 th Edition did not consider their unique bio logical behavior. At present, oropharyngeal carcinomas are subdivided into p16 positive and p16 negative tumors, based on their expression of p16, a surrogate marker of high--risk HPV. Purpose: This review summarizes current knowledge of HPV-associated oropharyngeal carcinomas with emphasis on their molecular features and histopathology, as well as summarizes and compares HPV detection methods and genotyping techniques. This review also describes the prognostic significance of p16 expression in these tumors and significant changes in the staging of oropharyngeal carcinomas based on p16 expression, together with the justifications for these changes.

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Prognostic impact of combined immunoprofiles in oropharyngeal squamous cell carcinoma patients with respect to AJCC 8th edition

Cited by 6 publications

References 29 publications

Prognostic significance of neutrophil‐to‐lymphocyte ratio in HPV status era for oropharyngeal cancer

Prognostic significance of neutrophil‐to‐lymphocyte ratio in HPV status era for oropharyngeal cancer

MicroRNA-15b-5p Predicts Locoregional Relapse in Head and Neck Carcinoma Patients Treated With Intensity-modulated Radiotherapy

Current Perspective on HPV-Associated Oropharyngeal Carcinomas and the Role of p16 as a Surrogate Marker of High-Risk HPV

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