Prognostic Value of Neutrophil-to-lymphocyte Ratio and Establishment of Novel Preoperative Risk Stratification Model in Bladder Cancer Patients Treated With Radical Cystectomy

Gondo, Tatsuo; Nakashima, Jun; Ohno, Yoshio; Ozu, Choichiro; Horiguchi, Yutaka; Namiki, Kazunori; Yoshioka, Kunihiko; Ohori, Makoto; Hatano, Tadashi; Tachibana, Masaaki

doi:10.1016/j.urology.2011.11.070

Cited by 217 publications

(190 citation statements)

References 24 publications

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“…An elevated NLR before cystectomy has been associated with decreased overall and DSS. [6][7][8][9][10] In our study, NLR was significantly associated with DSS similar to previous reports. 6,10 In contrast, Demirtas and colleagues did not find a significant association between patients with an NLR >2.5 and overall survival.…”

Section: Discussionsupporting

confidence: 92%

“…[6][7][8][9][10] In our study, NLR was significantly associated with DSS similar to previous reports. 6,10 In contrast, Demirtas and colleagues did not find a significant association between patients with an NLR >2.5 and overall survival. 15 On the other hand, a hematopoietic parameter, leukocytosis, which may be a possible prognostic factor, has largely been limited to individual case reports of paraneoplastic syndromes within the published data on urothelial carcinoma.…”

Section: Discussionsupporting

confidence: 92%

“…5 Neutrophil count, lymphocyte count or neutrophil-to-lymphocyte ratio (NLR) can be independent prognostic and predictive systematic inflammatory markers for unfavourable survival in patients with urinary tract malignancies. [6][7][8][9] Although elevated NLR and poor overall and disease-specific survival (DSS) in muscle-invasive disease have been reported, 10 to date, the prognostic significance of leukocytosis in patients with bladder carcinoma treated with radical cystectomy has not yet been determined. Therefore, we evaluated the prognostic impact of preoperative leukocytosis in patients with bladder carcinoma treated with radical cystectomy.…”

Section: Introductionmentioning

confidence: 99%

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The prognostic significance of preoperative leukocytosis and neutrophil-to-lymphocyte ratio in patients who underwent radical cystectomy for bladder cancer

Özcan

Telli

Öztürk

et al. 2015

CUAJ

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Introduction: We evaluated the prognostic effects of hematologic parameters of preoperative leukocytosis and neutrophil-to-lymphocyte ratio (NLR) in patients who underwent radical cystectomy for bladder cancer. Methods: We retrospectively reviewed the medical records of 363 patients who underwent radical cystectomy for bladder cancer between January 1990 and June 2013. In total, 286 patients were included in the study. Age, gender, pathologic stage, lymph node involvement, preoperative hydronephrosis, histologic subtype, surgical margin status, and lymphovascular invasion were recorded for each patient. Univariate and multivariate analysis were performed to determine the prognostic value of the preoperative clinical and laboratory parameters on disease-specific survival (DSS). Additionally, the correlation between leukocytosis and other factors were evaluated. Results: According to the univariate analysis preoperative leukocytosis and NLR were detected as negative prognostic factors on DSS. Preoperative leukocytosis, NLR, stage, lymph node involvement, histologic subtype, grade and age were independent prognostic factors for DSS, on multivariate analysis. Patients with leukocytosis had higher stage, grade and lymphovascular invasion. Conclusions: Inexpensive, reproducible, and readily available peripheral blood count components of white blood cell count and NLR were independent prognostic factors, which can stratify DSS risks in bladder cancer patients who underwent radical cystectomy.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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The prognostic significance of preoperative leukocytosis and neutrophil-to-lymphocyte ratio in patients who underwent radical cystectomy for bladder cancer

Özcan

Telli

Öztürk

et al. 2015

CUAJ

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“…[149] Urothelial carcinoma An NLR>2.5 was found to be a predictor of invasiveness. [433] overexpressed in hepatocellular carcinoma from patients with recurrent disease as well as in highly metastatic hepatocellular carcinoma cell lines [381].…”

Section: Prognostic Values Of Neutrophils and Other Myeloid Subtypes mentioning

confidence: 96%

The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment

Sionov

Fridlender

Granot

2014

Cancer Microenvironment

323

254

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Neutrophils are myeloid cells that constitute 50-70 % of all white blood cells in the human circulation. Traditionally, neutrophils are viewed as the first line of defense against infections and as a major component of the inflammatory process. In addition, accumulating evidence suggest that neutrophils may also play a key role in multiple aspects of cancer biology. The possible involvement of neutrophils in cancer prevention and promotion was already suggested more than half a century ago, however, despite being the major component of the immune system, their contribution has often been overshadowed by other immune components such as lymphocytes and macrophages. Neutrophils seem to have conflicting functions in cancer and can be classified into anti-tumor (N1) and pro-tumor (N2) sub-populations. The aim of this review is to discuss the varying nature of neutrophil function in the cancer microenvironment with a specific emphasis on the mechanisms that regulate neutrophil mobilization, recruitment and activation.

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“…[26] Morizawa et al [28] showed that the pretreatment NLR (≥2.6) and an infiltrative growth pattern at the tumor invasion front were significantly associated with recurrence-free survival, cancer-specific survival and overall survival. Gondo et al [29] observed that NLR was an independent prognostic factor with a NLR cut-off value of 2.5. With a similar cut-off value, Krane et al [30] reported that the patients with elevated NLR before RC have worse overall survival than patients without markers of systemic inflammation.…”

Section: Discussionmentioning

confidence: 99%

Predictive role of neutrophil-to-lymphocyte ratio on upstaging of organ-confined invasive urothelial bladder cancer to non-organconfined disease

Şefik

Günlüsoy

Aydoğdu

et al. 2018

Turkish Journal of Urology

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Objective: The aim of this study is to examine the usefulness of preoperative neutrophile-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lymphocyte-to-monocyte ratios to predict pathological upstaging of invasive bladder cancer who underwent radical cystectomy. Material and methods:A total of 126 patients who underwent radical cystectomy at our clinic between January 2006 and March 2015 were retrospectively analysed. One hundred and twelve patients with organconfined invasive bladder tumors (T2) detected at histopathological examination of transuretral resection material were included in the study. Upstaging was seen at histopathological examination of radical cystectomy specimens of 42 patients. We compared preoperative neutrophile-to-lymphocyte ratio, platelet-tolymphocyte ratio, lymphocyte-to-monocyte ratio between upstaged and not-upstaged groups.Results: There were no statistically significant correlation between age, time to radical cystectomy, gender, lymphocyte-to-monocyte ratio, platelet-to-lymphocyte ratio ratios and carcinoma in situ in upstaged and non-upstaged groups. Statistical analyses showed that preoperative neutrophile-to-lymphocyte ratio was higher in upstaged patients (p= 0.009). In multivariate analysis preoperative neutrophile-to-lymphocyte ratio and positive surgical margin were significantly higher in upstaged group. Conclusion:In organ-confined muscle invasive bladder cancer neutrophile-to-lymphocyte ratio seems to be an acceptable parameter to predict locally advanced disease.

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Prognostic Value of Neutrophil-to-lymphocyte Ratio and Establishment of Novel Preoperative Risk Stratification Model in Bladder Cancer Patients Treated With Radical Cystectomy

Cited by 217 publications

References 24 publications

The prognostic significance of preoperative leukocytosis and neutrophil-to-lymphocyte ratio in patients who underwent radical cystectomy for bladder cancer

The prognostic significance of preoperative leukocytosis and neutrophil-to-lymphocyte ratio in patients who underwent radical cystectomy for bladder cancer

The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment

Predictive role of neutrophil-to-lymphocyte ratio on upstaging of organ-confined invasive urothelial bladder cancer to non-organconfined disease

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