Prognostic value of neutrophil-to-lymphocyte ratio in colorectal cancer liver metastasis: A meta-analysis of results from multivariate analysis

Lin, Nanping; Li, Jingrong; Yao, Xiangqing; Zhang, Xiang; Liu, Guozhong; Zhang, Zhibo; Weng, Shangeng

doi:10.1016/j.ijsu.2022.106959

Cited by 29 publications

(29 citation statements)

References 45 publications

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“…According to the results of univariable and multivariable COX regression analyses, the mediator effect of TCI might exist in the relationship between NLR and OS, as following facts 1 : TCI was significantly correlated with the NLR ( p < 0.05) and survival ( p < 0.05), (Table 1 and Table 2) 2 ; NLR was significantly associated with OS ( p < 0.001) in univariable analysis (Table 2), 3 the correlation intensity between NLR and OS weakened after controlling TCI in multivariable analysis (Table 2). Mediation analysis indicated that CD3+ TCI had significant mediation effects on the association between NLR and overall survival ( p < 0.001), which explains about 9.21% of the association (Figure 4).…”

Section: Resultsmentioning

confidence: 97%

“…Meanwhile, numerous novel prognostic factors, such as neutrophil‐to‐lymphocyte ratio (NLR), have emerged 2 . NLR is one of the systemic inflammation markers that correlate with clinical outcomes of various cancers, including gastric cancer, colorectal cancer, pancreatic cancer, and liver cancer 3–5 . The prognostic role of NLR in GC has been extensively reported by different groups 6–9 .…”

Section: Introductionmentioning

confidence: 99%

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T‐cells infiltration mediates the association between neutrophil/lymphocyte ratio and survival in gastric cancer

He,

Huangfu,

Fan

et al. 2023

Cancer Medicine

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BackgroundNeutrophil/lymphocyte ratio (NLR) is a vital index for systemic inflammation and a prognostic indicator for gastric cancer (GC). Despite the abundant literature on NLR's prognostic value for GC, the underlying factors mediating its impact on survival remain unclear. The objective of this study was to analyze the role of NLR in different prognostic models and subgroups, and investigate the mediating effects of immune infiltrates between NLR and survival.MethodsA total of 924 patients who underwent D2 lymph node resection were enrolled in this study. According to the level of NLR, patients were divided into two groups, the high and low NLR groups. Clinical parameters, indexes related to immune infiltrates, and survival were compared between the two groups. Prognostic models, interaction analysis, and mediating effects analysis were performed to investigate the clinical association of NLR, immune infiltrates, and survival.ResultsThe infiltration of CD3+ and CD8+ T cells was significantly different in the two NLR groups. The level of NLR was an independent prognostic predictor of GC. In addition, an interaction effect exists between NLR and MMR status on the prognosis of GC (p‐interaction <0.01). Lastly, the mediating effect analysis revealed that the infiltration level of CD3+ T cells was the mediating factor between NLR and survival (p < 0.001).ConclusionsThe level of NLR is an independent prognostic predictor of GC. The effect of NLR on prognosis is partly mediated by CD3+ T‐cell infiltration.

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Section: Resultsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

T‐cells infiltration mediates the association between neutrophil/lymphocyte ratio and survival in gastric cancer

He,

Huangfu,

Fan

et al. 2023

Cancer Medicine

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“…At the same time, platelets play an important role in protecting cancer cells from chemotherapy-induced apoptosis and maintaining the integrity of tumor vasculature (6,22). Lymphocytes include T cells, B cells, and natural killer (NK) cells, which are the main immune cells of the body to kill tumors, and reduction of lymphocytes indicates that patients with PLC have a reduced ability to kill tumor cells (23)(24)(25). Systemic immune inflammation index = (neutrophils * platelets)/ lymphocytes, so when the systemic immune inflammation index is elevated, it indicates an increase in neutrophils and platelets, and a decrease in lymphocyte levels, which indicates that tumor cells are more likely to proliferate and metastasize, resulting in recurrence or metastasis in patients with PLC after treatment.…”

Section: Discussionmentioning

confidence: 99%

Association between the systemic immune inflammation index and recurrence or metastasis after interventional therapy in patients with primary liver cancer- a retrospective cohort study

Yu¹,

Zheng²,

Yang³

et al. 2023

J Gastrointest Oncol

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Background: The systemic immune inflammation index has been used to evaluate the prognosis of patients with a variety of malignant tumors. However, studies were limited in primary liver cancer (PLC) patients. This study aimed to investigate the association between the systemic immune inflammation index and recurrence or metastasis after interventional therapy in patients with PLC. Methods:From January 2016 to December 2017, 272 patients with PLC admitted to the 941st Hospital of PLA Joint Logistics Support Force were retrospectively collected. All patients received interventional treatment, there were no residual lesions after interventional treatment. The patients were followed up for 5 years to monitor the rates of recurrence or metastasis. The patients were divided into a recurrence or metastasis group (n=112) and a control group (n=160). The differences in clinical features between the 2 groups were compared, and the predictive value of systemic immune inflammation index on recurrence or metastasis after interventional treatment in patients with PLC was analyzed.Results: Compared with the control group (8.12%), the proportion of patients with ≥2 lesions in the recurrence or metastasis group (19.64%) was significantly increased (P=0.005); the proportion of patients with vascular invasion was significantly increased in the recurrence or metastasis group (10.71% vs. 4.38%, P=0.044); albumin decreased significantly in the recurrence or metastasis group (39.69±6.17 vs. 41.69±6.82 g/L, P=0.014); neutrophils (%) were significantly increased in the recurrence or metastasis group (0.70±0.08 vs. 0.64±0.08, P<0.001); lymphocytes (%) were significantly reduced in the recurrence or metastasis group (0.25±0.06 vs. 0.30±0.06, P<0.001); and platelet count was significantly increased in the recurrence or metastasis group (179.22±39.52 vs. 160.81±34.13 10 9 /L, P<0.001). The systemic immune inflammation index was significantly increased in the recurrence or metastasis group (535.23±174.05 vs. 357.84±120.21, P<0.001). Systemic immune inflammation index was valuable in predicting recurrence or metastasis, and the area under the curve was 0.795 (95% CI: 0.742-0.848, P<0.001). Systemic immune inflammation index >405.08 was an independent risk factor of recurrence or metastasis [relative risk (95% CI: 1.878-5.329), P=0.000].Conclusions: Elevated systemic immune inflammation index is associated with recurrence or metastasis after interventional therapy in patients with PLC.

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“…9,10 Lymphocytes have been reported to play a significant role in mediating the inflammatory response at all phases of the atherosclerotic process and can lead to rupture of atherosclerotic plaques. 9 Recently, increased NLR was reported to be associated with malignant tumors, 11 inflammatory disease, 12 stoke, 13 and other diseases . In addition, both high neutrophil counts and lymphocytopenia were found to be associated with cardiovascular disease, 14,15 hence, neutrophil to lymphocyte ratio (NLR) has emerged as a new inflammation marker, which can better reflect the state of systematic inflammation.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, increased NLR was reported to be associated with malignant tumors, 11 inflammatory disease, 12 stoke, 13 and other diseases . In addition, both high neutrophil counts and lymphocytopenia were found to be associated with cardiovascular disease, 14,15 hence, neutrophil to lymphocyte ratio (NLR) has emerged as a new inflammation marker, which can better reflect the state of systematic inflammation.…”

Section: Introductionmentioning

confidence: 99%

The neutrophil-to-lymphocyte ratio, as an emerging marker, is an important indicator predicting spontaneous reperfusion and clinical prognosis in patients with ST-segment elevation myocardial infarction

Zhang

et al. 2023

Preprint

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Background: Neutrophil to lymphocyte ratio (NLR) has emerged as a new inflammation marker, which plays a major role in plaque instability, rupture, and erosion, and facilitates its progression, leading to acute myocardial infarction. The study aims to explore the role of NLR in predicting spontaneous reperfusion (SR) and prognosis in patients with ST-segment elevation myocardial infarction (STEMI). Methods: This was a retrospective analysis including 506 STEMI patients undergoing primary percutaneous coronary intervention treatment, who were divided into two groups according to the thrombolysis in myocardial infarction (TIMI) flow: SR group (69 patients, initial TIMI flow 3) and No-SR group (437 patients, initial TIMI flow 0-2). Results: The incidence of SR was 13.6%. SR group was associated with a remarkably lower level of NLR [5.14 (2.97, 7.02) vs. 8.03 (4.54, 10.92), P<0.001], more proportions of final TIMI 3 flow (98.6% vs. 91.5%, P < 0.05), lower incidence of congestive heart failure (8.7% vs. 18.5%, P < 0.05), and significantly better outcomes. Using multivariate logistic regression analysis, NLR (OR: 0.799, 95% CI: 0.730-0.874, P < 0.001) and fasting blood glucose were the independent predictors of SR. On multivariate Cox regression analysis, NLR (HR: 1.035, 95% CI: 1.001-1.071, P < 0.05) was the independent predictor of MACEs during follow-up. Conclusions: NLR had the ability in predicting SR in STEMI patients and SR flow was associated with a favorable outcome. We also revealed an association between NLR and increased risk of MACEs during follow-up.

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Prognostic value of neutrophil-to-lymphocyte ratio in colorectal cancer liver metastasis: A meta-analysis of results from multivariate analysis

Cited by 29 publications

References 45 publications

T‐cells infiltration mediates the association between neutrophil/lymphocyte ratio and survival in gastric cancer

T‐cells infiltration mediates the association between neutrophil/lymphocyte ratio and survival in gastric cancer

Association between the systemic immune inflammation index and recurrence or metastasis after interventional therapy in patients with primary liver cancer- a retrospective cohort study

The neutrophil-to-lymphocyte ratio, as an emerging marker, is an important indicator predicting spontaneous reperfusion and clinical prognosis in patients with ST-segment elevation myocardial infarction

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