Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Penile Squamous Cell Carcinoma Patients Undergoing Inguinal Lymph Node Dissection

Azizi, Mounsif; Peyton, Charles C.; Boulware, David; Chipollini, Juan; Juwono, Timothy; Pow‐Sang, Julio M.; Spiess, Philippe E.

doi:10.1016/j.euf.2018.06.008

Cited by 21 publications

(41 citation statements)

References 26 publications

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“…Recently, an elevated ratio of peripheral neutrophils-to-lymphocytes (NLR) has been recognized as a poor prognostic indicator in penile cancer, Patients with a high NLR had signi cantly worse CSS [17,18] and OS [16];Patients with a low LMR had signi cantly worse RFS and CSS than those with a high LMR [18].…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of systemic inflammatory factors NLR, LMR, PLR and LDH in penile cancer

Chen¹,

Li²,

Zhang³

et al. 2020

Preprint

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Background: Penile squamous cell carcinoma (PSCC)represents an important public health problem for developing countries. The major prognostic factors in PSCC are pathological subtype, perineural invasion, lymphovascular invasion, depth of invasion and grade, which are hard to obtain precisely before the operation. Besides, micro-metastases will be detected in about 30% of intermediate-risk patients with clinically non-palpable inguinal lymph nodes after i nguinal lymph node dissection( ILND ) . It means approximately 70% of patients are unable to benefit from ILND who might suffered from the complications of surgery. We hope some biomarkers could be found which are able to predict the outcome before surgery and reflect the inguinal lymph nodes metastasis. Methods: A total of 349 consecutive patients of penile cancer in Yunnan cancer hospital in China between October 2002 and December2017. 225 was succeed to follow-up. According to the (AUROC) curve, we get the cut-off point, K-M analysis and multivariate logistic regression models and Bivariate correlations were used to detect the results. The association between NLR,LMR,PLR,LDH and Overall survival(OS),progression free survival(PFS) , inguinal lymph node (N stage) was analyzed with K-M analysis, univariable, multivariable logistic regression and Kendall’s tau-b correlation coefficient. Results: Multivariate analysis reveal that only PLR was significant independent factor which is associated with inferior OS and PFS; Age and LDH was associated with inferior OS; Lymph node and metastatic status remained significant for OS and PFS as NCCN and EAU Guidelines indicated; the ages, tumor type, initial treatment and NLR LMR were not significant in predicting both OS and PFS. NLR, LMR and PLR were corresponded to N stage, while LDH was not associated with the N stage based on logistic regression model analysis. NLR, LMR and PLR were found weakly related to N stage through an application of Kendall’s tau-b correlation coefficient. Conclusions: PLR was significant independent factors for OS and PFS, Age and LDH was significant independent factors for OS. NLR, LMR, PLR was corresponded to N stage.

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Section: Discussionmentioning

confidence: 99%

Prognostic value of systemic inflammatory factors NLR, LMR, PLR and LDH in penile cancer

Chen¹,

Li²,

Zhang³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Recently, an elevated ratio of peripheral neutrophils-to-lymphocytes (NLR) has been recognized as a poor prognostic indicator in penile cancer, Patients with a high NLR had significantly worse CSS [17,18] and OS [16];Patients with a low LMR had significantly worse RFS and CSS than those with a high LMR [18].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of systemic inflammatory factors(NLR,LMR,PLR) and LDH in penile cancer

hu¹,

Li²,

Zhang³

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: Penile squamous cell carcinoma (PSCC)represents an important public health problem for developing countries, the major prognostic factors in PSCC are Pathological subtype, perineural invasion, lymphovascular invasion, depth of invasion and grade, these factors are hard to precisely obtain before the operation. Besides, intermediate-risk patients with clinically non-palpable inguinal lymph nodes , only about 30% of them are able to detect micro-metastases after ILND. That means the rest of patients approximately 70% have no benefit from ILND and suffered from the complications of surgery, so we hope to find some biomarkers that help us to predict the outcome before surgery and reflect the inguinal lymph nodes metastatic. Methods: A total of 349 consecutive patients of penile cancer at Yunnan cancer hospital in China between October 2002 and December2017. 225 was succeed to follow-up. According to the (AUROC) curve, we get the cut-off point, K-M analysis and multivariate logistic regression models and Bivariate correlations were used to detect the results. Results: Multivariate analysis reveal NLR, LMR, PLR was significant independent factors was associated with inferior OS; Only PLR was associated with inferior PFS; LDH was not associated with inferior OS and PFS. Anatomic stage and lymph node status remained significant for OS and PFS as NCCN and EAU Guidelines indicated；The tumor type and primary treatment was not significant for OS and PFS. In logistic regression analyses NLR, LMR, PLR was corresponded to N stage which divided into the Node-negative group and Node-positive groups, however the LDH was not associated with the N stage. However Kendall’s tau-b evaluated the correlations, NLR, LMR, PLR were weakly correlated to the N stage. Conclusions: NLR and LMR was significant independent factors for OS, PLR was significant independent factors both for OS and PFS. NLR, LMR, PLR was significant corresponded to N stage.

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“…In logistic regression analyses, NLR (HR = 2.212; 95% CI: 1.228-3.985,p = 0.008), LMR(HR = 0.537; 95% CI: 0.308-0.937,p = 0.029), PLR(HR = 2.478; 95% CI:1.365-4.497,p = 0.003) was significant Recently, an elevated ratio of peripheral neutrophils-to-lymphocytes (NLR) has been recognized as a poor prognostic indicator in penile cancer, Patients with a high NLR had significantly worse CSS [17,18] and OS [16];Patients with a low LMR had significantly worse RFS and CSS than those with a high…”

Section: Nlr Lmr Plr Ldh Vs Inguinal Lymph Node-negative/positivementioning

confidence: 99%

“…Recently it has been reported that cancer patients with high NLR is associated with worse OS [16]and worse RFS and CSS [17,18]. However, there has been no study evaluating the PLR associated with outcomes of penile cancer.…”

mentioning

confidence: 99%

Prognostic Value of systemic inflammatory factors NLR, LMR, PLR and LDH in penile cancer

hu¹,

Li²,

Zhang³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Penile squamous cell carcinoma (PSCC)represents an important public health problem for developing countries. The major prognostic factors in PSCC are pathological subtype, perineural invasion, lymphovascular invasion, depth of invasion and grade, which are hard to obtain precisely before the operation. Besides, micro-metastases will be detected in about 30% of intermediate-risk patients with clinically non-palpable inguinal lymph nodes after i nguinal lymph node dissection( ILND ) . It means approximately 70% of patients are unable to benefit from ILND who might suffered from the complications of surgery. We hope some biomarkers could be found which are able to predict the outcome before surgery and reflect the inguinal lymph nodes metastasis. Methods: A total of 349 consecutive patients of penile cancer in Yunnan cancer hospital in China between October 2002 and December2017. 225 was succeed to follow-up. According to the (AUROC) curve, we get the cut-off point, K-M analysis and multivariate logistic regression models and Bivariate correlations were used to detect the results. The association between NLR,LMR,PLR,LDH and Overall survival(OS),progression free survival(PFS) , inguinal lymph node (N stage) was analyzed with K-M analysis, univariable, multivariable logistic regression and Kendall’s tau-b correlation coefficient. Results: Multivariate analysis reveal that only PLR was significant independent factor which is associated with inferior OS and PFS; LDH was associated with inferior OS; Lymph node and metastatic status remained significant for OS and PFS as NCCN and EAU Guidelines indicated; the ages, tumor type, initial treatment and NLR LMR were not significant in predicting both OS and PFS. NLR, LMR and PLR were corresponded to N stage, while LDH was not associated with the N stage based on logistic regression model analysis. NLR, LMR and PLR were found weakly related to N stage through an application of Kendall’s tau-b correlation coefficient. Conclusions: PLR was significant independent factors for OS and PFS, and LDH was significant independent factors for OS. NLR, LMR, PLR was corresponded to N stage.

show abstract

Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Penile Squamous Cell Carcinoma Patients Undergoing Inguinal Lymph Node Dissection

Abstract: Penile cancer is a rare malignancy in North America and Europe. Therefore, there is a lack of prognostic parameters to help predict oncologic and survival outcomes. In this report, patients with an elevated neutrophil-to-lymphocyte ratio had an increased risk of mortality.

Cited by 21 publications

References 26 publications

Prognostic value of systemic inflammatory factors NLR, LMR, PLR and LDH in penile cancer

Prognostic value of systemic inflammatory factors NLR, LMR, PLR and LDH in penile cancer

Prognostic Value of systemic inflammatory factors(NLR,LMR,PLR) and LDH in penile cancer

Prognostic Value of systemic inflammatory factors NLR, LMR, PLR and LDH in penile cancer

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