Prognostic Value of Neutrophil-To-Lymphocyte Ratio and Platelet-To-Lymphocyte Ratio for Renal Outcomes in Patients with Rapidly Progressive Glomerulonephritis

Abstract

Background: Rapidly progressive glomerulonephritis (RPGN) is a syndrome characterized by a rapid decline in renal function that often causes end-stage renal disease. Although it is important to predict renal outcome in RPGN before initiating immunosuppressive therapies, no simple prognostic indicator has been reported. The aim of this study was to investigate the associations of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) to renal outcomes in patients with RPGN. Methods: Forty-four patients with a clinical diagnosis of RPGN who underwent renal biopsy were enrolled. The relationships between NLR and PLR and renal outcome after 1 year were investigated. Results: NLR and PLR were significantly higher in patients with preserved renal function in comparison to patients who required maintenance hemodialysis (p < 0.05 and p < 0.01, respectively). An NLR of 4.0 and a PLR of 137.7 were the cutoff values for renal outcome (area under the curve, 0.782 and 0.819; sensitivity, 78.4% and 89.2%; specificity, 71.4% and 71.4%, respectively). Furthermore, an NLR of 5.0 could predict recovery from renal injury in patients requiring hemodialysis (area under the curve, 0.929; sensitivity, 83.3%; specificity, 85.7%). Conclusion: NLR and PLR could be candidates for predicting renal outcomes in patients with RPGN.

The Relationship between Hematological Markers of Systemic Inflammation (Neutrophil-To-Lymphocyte, Platelet-To-Lymphocyte, Lymphocyte-To-Monocyte Ratios) and Ultrasound Disease Activity Parameters in Patients with Rheumatoid Arthritis

“…Recently, hematological parameters (Neutrophil-to-Lymphocyte ratio (NLR), Platelet-to-Lymphocyte ratio (PLR) and Lymphocyte-to-Monocyte ratio (LMR)) have come into use as markers of systemic inflammation. They have been reported to be highly sensitive measures of inflammation in the field of oncology (lung cancer, esophageal cancer, gastric cancer, and endometrial cancer), cardiology, nephrology, diabetes, infectious diseases, and autoimmune rheumatic diseases [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. Increased NLR and PLR have been reported to be associated with cancer [ 5 ], diabetes [ 7 ], and psoriasis [ 9 ].…”

“…LMR has been reported as a biomarker for infectious diseases, as a result of the balance between effector and host [ 1 ]. Elevated NLR was found as an independent predictor for in-hospital and long-term mortality in patients with acute heart failure [ 8 ], and NLR and PLR are candidates for predicting renal outcomes in patients with rapidly progressive glomerulonephritis [ 13 ].…”

Impact of endoscopic submucosal dissection and epithelial cell sheet engraftment on systemic cytokine dynamics in patients with oesophageal cancer

“…In the present study, we showed that the NLR increased in the acute phase after ESD. The NLR is reported to be a marker of systemic inflammation, tumour stage, and histological type of gastrointestinal carcinoma 20 – 22 . WBC and neutrophils are regulated by TNF-α, IL-1β, and IL-6.…”

Neutrophil-to-Lymphocyte Ratio Is a Useful Marker for Predicting Histological Types of Early Gastric Cancer

“…The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are representative blood markers of the systemic inflammatory response [ 4 ] and high NLR/PLR have been shown to be significantly associated with poor prognosis in a variety of malignancies [ 5 , 6 , 7 , 8 ]. Additionally, a close relationship between the systemic inflammatory response and tumor progression has been demonstrated in some types of cancers [ 9 , 10 ].…”