Neutrophil-to-Lymphocyte Ratio Is a Useful Marker for Predicting Histological Types of Early Gastric Cancer

Yasui, Sho; Takata, Tomoaki; Kamitani, Yu; Mae, Yukari; Kurumi, Hiroki; Ikebuchi, Yuichiro; Yoshida, Akira; Kawaguchi, Koichiro; Yashima, Kazuo; Isomoto, Hajime

doi:10.3390/jcm10040791

Cited by 8 publications

(6 citation statements)

References 27 publications

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“…Systemic inflammation is associated with changes in blood cells such as increased neutrophils, platelets, and MPV. [9][10][11] PLR is a simple inflammatory marker derived from the complete blood count. Previous studies have shown that the PLR was significantly higher in H. pylori-positive than in H. pylori-negative patients, 7 while other studies have disproved this finding.…”

Section: Resultsmentioning

confidence: 99%

A Link Between Platelet-to-Lymphocyte Ratio and Helicobacter pylori Infection

Frandeș

Chibulcutean

Bățagă

2021

Journal of Interdisciplinary Medicine

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Background: Gastritis is a progressive disease that evolves from a non-atrophic to an atrophic state and progresses through intestinal metaplasia, even leading to gastric cancer. Gastritis is defined by an inflammatory process of the mucosal lining of the stomach. Aim: We aimed to identify any association between Helicobacter pylori (H. pylori)-positive gastritis and simple inflammatory markers derived from a complete blood count such as the platelet-to-lymphocyte ratio (PLR). Material and Methods: We performed a retrospective case-control study in which we included patients who underwent an upper digestive endoscopy with biopsy between January 2019 and December 2020 and were diagnosed with gastritis. H. pylori status was determined from the histopathological examination, and complete blood count was performed from venous blood samples. The final study group included 125 patients with H. pylori-positive chronic gastritis, and the control group was made up by 207 patients without H. pylori infection. Results: We found a higher value of the PLR in H. pylori-positive patients than in the control group, but the difference was not significant statistically. Conclusions: PLR levels could be a predictor of inflammation in H. pylori infection, but an extensive study is needed to confirm this theory.

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Section: Resultsmentioning

confidence: 99%

A Link Between Platelet-to-Lymphocyte Ratio and Helicobacter pylori Infection

Frandeș

Chibulcutean

Bățagă

2021

Journal of Interdisciplinary Medicine

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“…[9] On GC patients, significantly higher NLR was observed in undifferentiated adenocarcinoma, compared to differentiated adenocarcinoma. [31] NLR < 4 was correlated and corresponded to significant high rate of successful conversion surgery among stage IV GC. [32] In addition, NLR is valuable marker for predicting the treatment response for oral squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

The diagnostic and prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio on gastric cancer patients

Nguyen

Pham

Le³

et al. 2023

Medicine

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Gastric cancer (GC) is the remaining concern of cancer-associated health burden. Valuable predictive and prognostic indicators support the early diagnosis and improve outcome. Immune escape and inflammation are important cancer hallmarks. The prognostic and diagnostic value of platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) was reported in some cancers. But these cheap and convenient indexes are far from clinical use. Thus, investigation the alteration of those index on GC is needed to impose the use of those indexes in clinic. The study recruited seventy-seven hospitalized patients newly diagnosed with GC and 90 healthy individuals. The clinical and preclinical data of participants were collected from Hospital Information Management system. This study were approved by the Ethical Committee, Vietnam Military Medical University. The data were analyzed on STATA version 14.0 and GraphPad Prism 8.0. The alteration of immunological system was reported by significantly higher white blood cell count, neutrophils, platelets, PLR, and NLR as well as decreased lymphocytes on GC, compared to healthy individuals. Those indexes were elevated on advanced stage GC, compared to early stage GC. Our receiver operating characteristic curve analysis showed the significant specificity and sensitivity of PLR (cutoff 135.0) and NLR (cutoff 2.0) on GC diagnosis with respective area under receiver operating characteristic curve of 84.74% and 85.17%, P < .0001. Besides, our results reported the tendency of increased PLR and NLR and short time from clinical signs to being diagnosed. PLR and NLR have significant specificity and sensitivity in diagnosis and prognosis of GC.

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“…In the present study, we showed that the NLR increased in the acute phase after ESD. The NLR is reported to be a marker of systemic inflammation, tumour stage, and histological type of gastrointestinal carcinoma 20 – 22 . WBC and neutrophils are regulated by TNF-α, IL-1β, and IL-6.…”

Section: Discussionmentioning

confidence: 99%

Impact of endoscopic submucosal dissection and epithelial cell sheet engraftment on systemic cytokine dynamics in patients with oesophageal cancer

Yoshida

Takata

Kanda

et al. 2021

Sci Rep

Self Cite

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The tumour microenvironment (TME) plays an important role in cancer development, progression, and metastasis. Various cytokines are present in the TME in oesophageal cancer. Oesophageal stricture is a major complication of endoscopic submucosal dissection (ESD) for oesophageal cancer, and inflammatory cytokines are closely related to its pathogenesis. However, the cytokine crosstalk involved in the oesophageal cancer TME and post-ESD stricture has not been fully elucidated. This study investigated the comprehensive cytokine dynamics following ESD in patients with oesophageal cancer. In addition, the effect of a novel preventive technique for post-ESD stricture, autologous cell sheet engraftment, on cytokine levels was evaluated. Various pro-inflammatory and anti-tumorigenic cytokines were elevated in patients with oesophageal cancer, and ESD transiently influenced cytokine concentrations. IL-1β and TNF-α, two major pro-inflammatory cytokines that induce oesophageal stricture, were significantly suppressed by cell sheet engraftment. In conclusion, this study revealed the distinct cytokine dynamics after ESD in patients with oesophageal cancer, together with the effect of autologous cell sheet engraftment on cytokine fluctuation. These results can accelerate research on the TME and therapeutic strategies for oesophageal cancer.

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Neutrophil-to-Lymphocyte Ratio Is a Useful Marker for Predicting Histological Types of Early Gastric Cancer

Cited by 8 publications

References 27 publications

A Link Between Platelet-to-Lymphocyte Ratio and Helicobacter pylori Infection

A Link Between Platelet-to-Lymphocyte Ratio and Helicobacter pylori Infection

The diagnostic and prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio on gastric cancer patients

Impact of endoscopic submucosal dissection and epithelial cell sheet engraftment on systemic cytokine dynamics in patients with oesophageal cancer

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