Prognostic value of neuron specific enolase and IL-10 in ischemic stroke and its correlation with degree of neurological deficit

Singh, Harsh Vardhan; Pandey, Anurag; Shrivastava, Amit Kumar; Raizada, Arun; Singh, Sanjeev Kumar; Singh, Neelima

doi:10.1016/j.cca.2013.02.014

Cited by 62 publications

(49 citation statements)

References 26 publications

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“…Furthermore, specific challenges regarding biomarkers of central nervous tissue include the penetration of BBB and the lack of correlation between functional symptoms and volume (as opposed to location) of injured tissue. According to pathophysiological processes underlying IS, potential inflammatory biomarkers may be classified as released by: (i) astroglial activation and neuronal injury (Table 1) [146,147,148,149,150,151,152,153,154,155,156,157]; (ii) systemic inflammatory response (Table 2) [158,159,160,161,162,163,164,165,166,167,168,169,170,171,172,173,174,175,176,177,178,179]; (iii) dysfunctional endothelium (Table 3) [180,181,182,183,184,185,186] (Figure 4). …”

Section: Inflammatory Mediators As Potential Diagnostic or Prognosmentioning

confidence: 99%

Update on Inflammatory Biomarkers and Treatments in Ischemic Stroke

Bonaventura

Liberale

Vecchiè

et al. 2016

IJMS

133

114

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After an acute ischemic stroke (AIS), inflammatory processes are able to concomitantly induce both beneficial and detrimental effects. In this narrative review, we updated evidence on the inflammatory pathways and mediators that are investigated as promising therapeutic targets. We searched for papers on PubMed and MEDLINE up to August 2016. The terms searched alone or in combination were: ischemic stroke, inflammation, oxidative stress, ischemia reperfusion, innate immunity, adaptive immunity, autoimmunity. Inflammation in AIS is characterized by a storm of cytokines, chemokines, and Damage-Associated Molecular Patterns (DAMPs) released by several cells contributing to exacerbate the tissue injury both in the acute and reparative phases. Interestingly, many biomarkers have been studied, but none of these reflected the complexity of systemic immune response. Reperfusion therapies showed a good efficacy in the recovery after an AIS. New therapies appear promising both in pre-clinical and clinical studies, but still need more detailed studies to be translated in the ordinary clinical practice. In spite of clinical progresses, no beneficial long-term interventions targeting inflammation are currently available. Our knowledge about cells, biomarkers, and inflammatory markers is growing and is hoped to better evaluate the impact of new treatments, such as monoclonal antibodies and cell-based therapies.

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Section: Inflammatory Mediators As Potential Diagnostic or Prognosmentioning

confidence: 99%

Update on Inflammatory Biomarkers and Treatments in Ischemic Stroke

Bonaventura

Liberale

Vecchiè

et al. 2016

IJMS

133

114

View full text Add to dashboard Cite

show abstract

“…NSE is a biomarker for brain damages commonly used in animal and human studies [22][23][24][25]. The control rats exhibited the highest mean of NSE level (6.26 ng/ml) when compared with the (S)-3,5-DHPG pretreated rats.…”

Section: Nse Levelmentioning

confidence: 99%

Preconditioning effect of (S)-3,5-dihydroxyphenylglycine on ischemic injury in middle cerebral artery occluded Sprague–Dawley rats

Ramli

Omar

Husin

et al. 2015

Neuroscience Letters

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“…Учитывая важную патогенетическую роль нейро-воспаления в церебральных поражениях, определение уровня провоспалительных цитокинов позволяет исполь-зовать их в качестве информативных критериев оценки тяжести поражения ЦНС [15,16]. Согласно результатам проведенных исследований, высокие уровни провос-палительных цитокинов при гипоксически-ишемическом поражении ЦНС отражают тяжесть повреждения голов-ного мозга у недоношенных новорожденных, являясь дополнительным повреждающим фактором для нейро-нов в постнеонатальном периоде [7,[16][17][18].…”

Section: актуальностьunclassified