Prognostic value of metabolic tumor volume measured by FDG-PET/CT in patients with cervical cancer

Lee

et al. 2014

Nucl Med Mol Imaging

Self Cite

Section: Discussionsupporting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Value of 18F-FDG PET/CT in the Detection of Ovarian Malignancy

Lee

et al. 2014

Nucl Med Mol Imaging

Self Cite

“…SUVmax based on body weight and MTV were determined by the attenuation-corrected PET data using volume viewer software. Of the various methods described for determining metabolic volume, a fixed threshold of SUV 2.5 was used [18,22,23]. The boundaries of tumor were drawn large enough to incorporate each target lesion in the axial, coronal and sagittal FDG PET/CT images.…”

Section: Assessment Of Mtv Tlg and Suvmax Of Primary Lung Lesionmentioning

confidence: 99%

Metabolic Tumor Volume Measured by F-18 FDG PET/CT can Further Stratify the Prognosis of Patients with Stage IV Non-Small Cell Lung Cancer

Yoo

Kim

Chong

et al. 2012

Nucl Med Mol Imaging

Purpose This study aimed to further stratify prognostic factors in patients with stage IV non-small cell lung cancer (NSCLC) by measuring their metabolic tumor volume (MTV) using F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). Materials and MethodsThe subjects of this retrospective study were 57 patients with stage IV NSCLC. MTV, total lesion glycolysis (TLG), and maximum standardized uptake value (SUVmax) were measured on F-18 FDG PET/CT in both the primary lung lesion as well as metastatic lesions in torso. Optimal cutoff values of PET parameters were measured by receiver operating characteristic (ROC) curve analysis. Kaplan-Meier survival curves were used for evaluation of progression-free survival (PFS). The univariate and multivariate Cox proportional hazards models were used to select the significant prognostic factors. Results Univariate analysis showed that both MTV and TLG of primary lung lesion (MTV-lung and TLG-lung) were significant factors for prediction of PFS (P<0.001, P00.038, respectively). Patients showing lower values of MTV-lung and TLG-lung than the cutoff values had significantly longer mean PFS than those with higher values. Hazard ratios (95 % confidence interval) of MTV-lung and

“…These parameters were recently reported to have prognostic value in several cancers, including lung, cervix, and ovary; however, there are limited data regarding EC. [11][12][13][14][15] We speculated that MTV and TLG, determined using preoperative PET/CT, could be prognostic factors predicting recurrence in EC patients. This study was designed to identify the prognostic value of these parameters for predicting recurrence and disease-free survival (DFS) in EC patients who underwent primary surgery.…”

Section: Introductionmentioning

confidence: 99%

Metabolic tumour volume and total lesion glycolysis, measured using preoperative ¹⁸F–FDG PET/CT, predict the recurrence of endometrial cancer

Shim

Kim

et al. 2014

BJOG

Objective To investigate the prognostic value of metabolic tumour volume (MTV) and total lesion glycolysis (TLG), measured by preoperative positron emission tomography and computerised tomography (PET/CT), in women with endometrial cancer.Design Retrospective cohort study. Methods Clinicopathological data for 84 women with endometrial cancer were reviewed from medical records. Cox proportional hazards modelling identified recurrence predictors. The receiver operating characteristic (ROC) curve was used to determine the cut-off value for predicting recurrence.Main outcome measure Disease-free survival (DFS).Results The number of patients with International Federation of Gynecology and Obstetrics (FIGO) stages were: I (58); II (11); III (13); and IV (2). The median DFS was 48 (1-85) months. By univariate analysis, DFS was significantly associated with FIGO stage, histology, peritoneal cytology, myometrial invasion, nodal metastasis, serum CA-125, MTV, and TLG. Using multivariate analysis, the MTV (P = 0.010; hazard ratio, HR = 1.010; 95% confidence interval, 95% CI = 1.002-1.018) and TLG (P = 0.024; HR = 1.001; 95% CI = 1.000-1.002) were associated with DFS. The area under the ROC curve was 0.679 (95% CI = 0.505-0.836) after discriminating for recurrence using an MTV cut-off value of 17.15 ml. Regarding TLG, the cut-off value was 56.43 g and the area under the ROC plot was 0.661 (95% CI = 0.501-0.827). Kaplan-Meier survival graphs demonstrated a significant difference in DFS between groups categorised using the cut-off values for MTV and TLG (P < 0.022 for MTV and P < 0.047 for TLG, by log-rank test).Conclusions Preoperative MTV and TLG could be independent prognostic factors predicting the recurrence of endometrial cancer.