Prognostic Value of Malic Enzyme and ATP-Citrate Lyase in Non-Small Cell Lung Cancer of the Young and the Elderly

Csanádi, Ágnes; Kayser, Claudia; Donauer, Marcel; Gumpp, Vera; Aumann, Konrad; Rawluk, Justyna; Prasse, Antje; Hausen, Axel zur; Wiesemann, Sebastian; Werner, Martin; Kayser, Gian

doi:10.1371/journal.pone.0126357

Cited by 36 publications

(30 citation statements)

References 38 publications

(46 reference statements)

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“…Hanai et al () indicated that ACL deficiency is correlated with MET, differentiation and apoptosis in NSCLC (A549), leading to the inhibition of tumor growth in vivo. Clinically, ACL was also found to be upregulated and associated with local tumor stage, suggesting a prognostic value on NSCLC (Csanadi et al, ). It is therefore possible that the ATP concentration can significantly affect the biological behaviors of tumors.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism

Liu

et al. 2018

Cell Biology International

291

190

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AMP-activated protein kinase (AMPK) is a conserved sensor of cellular energy change and is activated by increased AMP/ATP and/or ADP/ATP ratios. AMPK maintains the energy balance by decreasing the ATP-consuming processes such as transcription of synthetic fat genes and rRNA, the translation of ribosomal proteins, synthesis of cholesterol and fatty acid, while the metabolic pathways such as glucose and fatty transport, fatty acid oxidation, autophagy, mitochondrial synthesis and oxidative metabolism are increased to preserve ATP during energy deficiency. Recent advance has demonstrated that AMPK activity has a close association with the initiation and progression in various cancers. Here we review the mechanisms that AMPK controls energy metabolism through regulating ATP synthesis and consumption, and further discuss the deregulation of AMPK in cancers.

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Section: Introductionmentioning

confidence: 99%

Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism

Liu

et al. 2018

Cell Biology International

291

190

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“…Both ME and ATP-citrase lyase (ACLY) are enzymes related to aerobic glycolysis and fatty acid synthesis. They are both correlated with NSCLC cells, and ACLY tends to be more localized, whereas ME tends to signify mediastinal lymph nodes, a site of metastasis in the human body [34]. Interestingly, in young patients, overexpression of ACLY and/or ME correlated with extended survival compared to patients who did not overexpress ACLY and/or ME.…”

Section: Mitochondrial Respiration and Biogenesis Genes Are Upregulatmentioning

confidence: 96%

“…Furthermore, some of the genes that were found to be upregulated in smokers were upregulated more depending on how frequently the smoker smoked. Malic enzyme (ME) expression is also significantly increased in the lung tissues of smokers compared to nonsmokers [34]. The EGFR pathway is the most common signaling pathway for lung cancer, and the mutation rate of genes of the EGFR pathway reach 70-80% [32].…”

Section: Mitochondrial Respiration and Biogenesis Genes Are Upregulatmentioning

confidence: 99%

The Bioenergetic Role of Mitochondria in Lung Cancer

FitzGerald¹,

Konduri²,

Vidal³

et al. 2017

A Global Scientific Vision - Prevention, Diagnosis, and Treatment of Lung Cancer

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In 1920s, Otto Warburg made the observation that cancer cells utilize significantly more glucose than normal, healthy cells, which led him to believe that cancer cells relied on glycolysis more than healthy cells. However, many subsequent studies have shown that glucose is not only necessary for glycolysis but also for oxidative phosphorylation and production of building blocks for the synthesis of other molecules. There are many challenges associated with studying and treating lung cancer, and there is a diverse set of metabolic factors influencing the tumorigenesis and metastasis of lung cancer. Lung cancer cells rely heavily on mitochondrial respiration, and several studies have shown that inhibiting mitochondrial function is an effective method to combat lung cancer. Several agents have been used to inhibit mitochondrial function, including cyclopamine and metformin. Further, more research has noted increased levels of heme flux and function as critical to intensified oxygen consumption and accompanying amplified pathogenesis and progression of lung cancer. The upregulation of mitochondrial DNA and biogenesis genes are also correlated with lung cancer. In this chapter, we will cover these recent and emerging topics in lung cancer bioenergetics research.

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“…In this study a total of 79 subjects with tumours of the ocular adnexa who had been treated at the Eye Center of Freiburg University between 1995 and 2012 were included. Clinical data, such as histological diagnosis, age at diagnosis, gender, treatment modality, follow-up time, local recurrences, metastasis and/or death, were collected on each subject from patient charts, primary care physicians and the Clinical Tumour Registry of the Medical Center at the University of Freiburg [6]. As some of the patients had already died at the time of this retrospective analysis, we could not obtain informed consent from all patients.…”

Section: Patientsmentioning

confidence: 99%