Prognostic value of Ki67 index in anaplastic oligodendroglial tumours – a translational study of the European Organization for Research and Treatment of Cancer Brain Tumor Group

Abstract

In AOT the Ki67 index has a strong prognostic impact on univariable analysis, but no independent influence on multivariable analysis. However, further prospective studies including larger numbers of cases and standardized evaluation of Ki67 index in conjunction with other relevant prognostic parameters are needed to draw definitive conclusions.

Original article Proliferation index revisited in neuroblastic tumors

“…The assessment of whether the prognostic impact of Topo2A is due to its value as a predictor of response to a treatment-based regimen or as a pure prognostic factor is still difficult to establish [5,12,29]. Similar to the studies on other cancers [1,5,18,21], we have shown that NB patients with high Topo2A PI experience significantly shorter OS. Also, Topo2A strongly correlated with Ki-67 ( Fig.…”

“…Likewise, the assessment of topoisomerase II alpha (Topo2A) expression emerges as a prolifera-tion marker in several cancer types, including brain tumors [12,26,29]. Ki-67 nuclear protein is required for maintaining cell proliferation, as it is detectable in all active phases of the cell cycle (G1, S, G2 and M) but absent in the resting phase G0 [21,28]. Accordingly, it serves for the determination of the growth fraction of a given cell population.…”

Ki-67 is a Valuable Prognostic Factor in Gliomas: Evidence from a Systematic Review and Meta-analysis

“…The value of Ki-67 for molecular staging of glioma also needs to be confirmed in controlled trials involving larger number of patients with longer follow-up, before any definitive conclusions can be made. Preusser et al, 2012). In our systematic review with meta-analysis, patients with Ki-67 positive tumors had significantly worse survival than those with Ki-67 negative ones.…”

Ultrasound Exposure Improves the Targeted Therapy Effects of Galactosylated Docetaxel Nanoparticles on Hepatocellular Carcinoma Xenografts

“…Survivin is the strongest apoptosis inhibitor in the currently known family of apoptosis inhibitor protein, and is highly expressed in liver cancer tissues [27][28][29]. Meanwhile, Ki67 is a marker with the highest sensitivity in the appraisal of cell proliferation and can satisfactorily reflect the differentiation of liver cancer cells [30][31][32]. The over-expressed Survivin and Ki67 is closely related with the biological characteristics of hepatocellular carcinoma; such as peplos invasion, tumor metastasis, and patient prognosis.…”