Ki-67 is a Valuable Prognostic Factor in Gliomas: Evidence from a Systematic Review and Meta-analysis

Chen, Wenjie; He, De-Shen; Tang, Rongjiang; Ren, Fanghui; Chen, Gang

doi:10.7314/apjcp.2015.16.2.411

Cited by 113 publications

(78 citation statements)

References 56 publications

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“…A systematic review and meta‐analysis of 52 studies by Chen et al. has supported the proposal that increased Ki‐67 proliferation is a predictor of poorer progression free and overall survival in intracranial glioma . In this meta‐analysis, only 23 studies included patients with GB and of these only 10 consisted solely of GB patients.…”

Section: Discussionmentioning

confidence: 69%

Cut‐point for Ki‐67 proliferation index as a prognostic marker for glioblastoma

Wong

Nahar

Hau

et al. 2018

Asia-Pac J Clncl Oncology

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Section: Discussionmentioning

confidence: 69%

Cut‐point for Ki‐67 proliferation index as a prognostic marker for glioblastoma

Wong

Nahar

Hau

et al. 2018

Asia-Pac J Clncl Oncology

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“…In view of its high sensitivity and specificity in neoplastic tissues, Ki-67 has been widely used as a reliable marker in various studies on oral neoplasms. [8][9][10][11] With this view in mind, the present study is designed to elucidate the biological behavior of the cancer cells in OSCC respective to their location, using Ki-67 immunological probe for cellular proliferation. Further, such probes can also reveal the cellular kinetics at the deepest and most invading front of the tumor, which is considered to be a significant histological site disclosing tumor aggression.…”

mentioning

confidence: 99%

Proliferative Index in Invasive Tumor Front of Oral Squamous Cell Carcinoma: A Potential Prognostic Indicator

Bhuyan¹,

Sarangi²,

Das³

et al. 2018

The Journal of Contemporary Dental Practice

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Aim:The aim of the study was to evaluate the proliferative index (PI) at their invasive front of oral cancer and their association with Bryne's grades of oral squamous cell carcinoma (OSCC) and compare the PI with lymph node metastasis, site of involvement, and habits. Materials and methods:The Ki-67 antigen expression was immunohistochemically evaluated in a total of 102 cases that included the histopathologically diagnosed archival specimens of OSCCs. They were subdivided by Bryne's histopathological grading into grade I (40 cases), grade II (32 cases), and grade III (30 cases). The nucleus with brown stain was considered positive. Cells were counted under 400× magnification. The proliferative activity thus determined was then expressed as a percentage of Ki-67 labeling index (Ki-67 LI) positive cells. Results:A stepwise increase in the mean Ki-67 LI was found from grade I to III squamous cell carcinoma, thus correlating with the histological grading. In addition, there was a higher PI seen in cases associated with metastatic lymph node, which concords with the higher biologic aggressiveness and poor prognosis of the lesion. Conclusion:The present study shows a definitive correlation of Ki-67 antigen with the Bryne's histological grading, all the parameters of Bryne's grading for OSCC and lymph node status of the patient proving its association as an effective tool to grade the tumors and finally read the prognosis of the tumor. Clinical significance: Cell proliferation is regarded as one of the most important biologic mechanisms in oncogenesis. The role of cell proliferation in tumor progression has been inferred in studies concerned with human cancer by comparing the PI of normal tissue, preneoplastic and neoplastic lesions. The Ki-67 antigen-labeled cells can prove to be an effective aid to grade the tumors. It might be possible to standardize and objectify tumor grading among pathology laboratories. Proliferative Index in Invasive Tumor

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“…The Ki‐67 protein is a marker strictly associated with cell proliferation determining the growth fraction of a given cell population . The fraction of Ki‐67‐positive tumor cells (the Ki‐67 labeling index) is often correlated with the clinical course of cancer …”

Section: Methodsmentioning

confidence: 99%

“…47 The fraction of Ki-67-positive tumor cells (the Ki-67 labeling index) is often correlated with the clinical course of cancer. 48 The CA-IX is a membrane-associated member of the carbonic anhydrase family, composed by enzymes that catalyze the interconversion of CO 2 and H 2 O to HCO 3 − and H + . Hence, it is involved in the maintenance of acid-base balance in blood and other tissues and helping transport CO 2 out of tissues.…”

Section: Histology and Immunohistochemistrymentioning

confidence: 99%

CEST‐MRI for glioma pH quantification in mouse model: Validation by immunohistochemistry

et al. 2018

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In glioma, the acidification of the extracellular tumor microenvironment drives proliferation, angiogenesis, immunosuppression, invasion and chemoresistance. Therefore, quantification of glioma extracellular pH (pHe) is of crucial importance. This study is focused on the application of the YbHPDO3A (ytterbium 1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane) probe for in vivo glioma pHe quantification using chemical exchange saturation transfer (CEST)-MRI and its correlation with tumor metabolism assessed by immunohistochemistry. The U87 glioma mouse model was used (n = 18) and MRI performed at 4.7 T. CEST-MRI of YbHPDO3A solutions at different pH values showed two resolved CEST spectra at 71 ppm and 99 ppm, both sensitive to pH variations, allowing therefore calculation of the ratiometric curve for in vivo pH quantification. In vivo MRI sequences consisted of T for tumor localization, T * to assess YbHPDO3A biodistribution by exploiting its magnetic susceptibility effect and CEST for glioma pHe mapping. T * images show that YbHPDO3A extravasates in tumor in regions with damaged blood-brain barrier. The pHe is calculated only in these regions. Hematoxylin/eosin histology and Ki-67, CA-IX (carbonic anhydrase 9) and NHE-1 immunohistochemical staining were performed; their expression rates were compared with the in vivo pHe values. On the basis of the cell proliferation marker Ki-67, two groups were defined: one group with a lower mitotic index (MI% < 20% = mean value) and a mean pHe value of 7.00 (low-proliferation/high-pH group) and the other with MI% > 20% and an acidic pHe of 6.6 (high-proliferation/low-pH group). CA-IX and NHE-1 were over-expressed in the high-proliferation/low-pH group (CA-IX, 92 ± 7% versus 30 ± 13%; NHE-1, 84 ± 8% versus 35 ± 11%), indicating an acidic/hypoxic microenvironment. These immunohistochemical results are consistent with our pHe mapping (Pearson correlation coefficient > 0.70) and provide evidence for the feasibility of the CEST-MRI method with the YbHPDO3A probe for glioma pHe quantification at 4.7 T. Importantly, the YbHPDO3A probe has similar chemical and biological properties to the clinically approved MRI contrast agent GdHPDO3A. This makes the method promising for a clinical translation.

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Ki-67 is a Valuable Prognostic Factor in Gliomas: Evidence from a Systematic Review and Meta-analysis

Abstract: we performed a systematic review of the literatures with meta-analysis to assess the prognostic value of Ki-67 for prognosis.

Cited by 113 publications

References 56 publications

Cut‐point for Ki‐67 proliferation index as a prognostic marker for glioblastoma

Cut‐point for Ki‐67 proliferation index as a prognostic marker for glioblastoma

Proliferative Index in Invasive Tumor Front of Oral Squamous Cell Carcinoma: A Potential Prognostic Indicator

CEST‐MRI for glioma pH quantification in mouse model: Validation by immunohistochemistry

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