Prognostic value of inflammation in prostate cancer progression and response to therapeutic: a critical review

Sciarra, Alessandro; Gentilucci, Alessandro; Salciccia, Stefano; Pierella, Federico; Bianco, Flavio Del; Gentile, Vincenzo; Silvestri, Ida; Cattarino, Susanna

doi:10.1186/s12950-016-0143-2

Cited by 56 publications

(46 citation statements)

References 73 publications

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“…Moreover, multivariate analysis showed that circulating CRP levels could be used as diagnostic factor for Sig‐PCa. These observations are in part consistent with some, but not all early reports showing that circulating CRP levels are associated with the prognosis of PCa (advanced and metastatic disease). Of note, our results also revealed that higher circulating CRP levels were associated with PCa aggressiveness since its circulating levels were positively associated with higher GS in our cohort of PCa patients.…”

Section: Discussionsupporting

confidence: 92%

Clinical association of metabolic syndrome, C‐reactive protein and testosterone levels with clinically significant prostate cancer

Gómez

Carrasco‐Valiente

Campos-Hernández

et al. 2018

J Cellular Molecular Medi

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Recently, the influence that metabolic syndrome (MetS), hormonal alterations and inflammation might have on prostate cancer (PCa) risk has been a subject of controversial debate. Herein, we aimed to investigate the association between MetS‐components, C‐reactive protein (CRP) and testosterone levels, and the risk of clinically significant PCa (Sig‐PCa) at the time of prostate biopsy. For that, men scheduled for transrectal ultrasound guided biopsy of the prostate were studied. Clinical, laboratory parameters and criteria for MetS characterization just before the biopsy were collected. A total of 524 patients were analysed, being 195 (37.2%) subsequently diagnosed with PCa and 240 (45.8%) meet the diagnostic criteria for MetS. Among patients with PCa, MetS‐diagnosis was present in 94 (48.2%). Remarkably, a higher risk of Sig‐PCa was associated to MetS, greater number of MetS‐components and higher CRP levels (odds‐ratio: 1.83, 1.30 and 2.00, respectively; P < 0.05). Moreover, higher circulating CRP levels were also associated with a more aggressive Gleason score in PCa patients. Altogether, our data reveal a clear association between the presence of MetS, a greater number of MetS‐components or CRP levels >2.5 mg/L with an increased Sig‐PCa diagnosis and/or with aggressive features, suggesting that MetS and/or CRP levels might influence PCa pathophysiology.

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Section: Discussionsupporting

confidence: 92%

Clinical association of metabolic syndrome, C‐reactive protein and testosterone levels with clinically significant prostate cancer

Gómez

Carrasco‐Valiente

Campos-Hernández

et al. 2018

J Cellular Molecular Medi

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“…In urologic cancer, a high PLR was significantly associated with worse prognosis of OS [22]. The result also indicated that an elevated PLR was significantly associated with poor OS in prostate cancer [22, 23]. In some studies, PLR has been demonstrated to be closely related to poor prognosis of patients with RCC [12, 24-26].…”

Section: Introductionmentioning

confidence: 99%

The Role of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio, and Platelets in the Prognosis of Metastatic Renal Cell Carcinoma

et al. 2019

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Objective(s): The aim of this analysis was to evaluate the platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), platelets (PLT), and neutrophil level for their prognostic value in patients with metastatic renal cell carcinoma (mRCC). Materials: We retrospectively reviewed medical records of 141 patients with mRCC (2006–2016). Univariate and multivariate analyses were performed with the Cox proportional hazards regression model. The cutoff value of NLR was “elevated” as >3.68 and the PLR cutoff value was “elevated” as >144.4. Results: The median PFS and OS were shorter in elevated NLR and PLR. A higher value of PLT was associated with worse median OS and higher neutrophil level with worse OS and PFS. In multivariate analysis, higher NLR (p = 0.007) and PLR (p = 0.006) were independent prognostic factors for shorter OS together with BMI ≤30 (p = 0.004), higher Fuhrman grade (p = 0.0002), lower level of hemoglobin (p= 0.010), and ZUBROD 2 (p = 0.0002). Higher PLR (p = 0.0002) was an independent negative prognostic factor for PFS together with higher Fuhrman grade (p = 0.001), higher neutrophil level (p = 0.001), and lower lymphocyte level (p = 0.013). Conclusion: Elevated pretreatment NLR, PLR, PLT, and neutrophil count are associated with shorter OS and PFS in patients with mRCC. NLR and PLR are independent prognostic factors for OS. However, PLR and neutrophil count are independent prognostic factors for PFS.

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“…In PCa, elevated NLR is clearly associated with poor overall survival, progressionfree survival, and recurrence-free suvival. [17,18] Other studies reported that NLR is useful in the early detection of PCa. [19,20] NLR has been more strongly and positively correlated with PSA than ESR or CRP in BPH.…”

Section: Discussionmentioning

confidence: 99%

Association between systemic inflammation and serum prostatespecific antigen in a healthy Korean population

Yun

Lee

Yang

2017

Turkish Journal of Urology

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Objective: Serum prostate-specific antigen (PSA) may be elevated in healthy men with systemic inflammation. We aimed to investigate the association between systemic inflammation markers and serum PSA in a healthy Korean population. Material and methods:A cohort of 20,151 healthy native Korean men without prostate disease between the ages of 40 and 65 years who underwent medical checkups were studied from January 2007 to December 2013. Serum total PSA and serum C-reactive protein concentrations, neutrophil, lymphocyte, and platelet counts were determined. The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) were calculated. We checked the correlation between systemic inflammation markers and PSA.Results: Data obtained from 18,800 healthy men were analyzed. The mean age of the study subjects was 50.72±7.62 years and the mean NLR was 1.764±0.804. Correlation analysis after adjustment for age and body mass index (BMI) revealed that neutrophil count (coefficient = 0.028, p value <0.001), and NLR (coefficient = 0.027, p value <0.001) correlated with PSA. Multivariate analysis using the full model revealed that age, neutrophil count and NLR were positively correlated with PSA (p<0.001, 0.001, and 0.043 respectively). Multivariate analysis using a stepwise model revealed that age, neutrophil count and NLR were positively correlated with PSA (p<0.001, 0.001, and 0.040, respectively) and BMI was negatively correlated with PSA (p<0.001). Conclusion:Systemic inflammation markers are useful with a serum PSA in a healthy Korean population. NLR in particular is significantly associated with serum PSA.

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Prognostic value of inflammation in prostate cancer progression and response to therapeutic: a critical review

Cited by 56 publications

References 73 publications

Clinical association of metabolic syndrome, C‐reactive protein and testosterone levels with clinically significant prostate cancer

Clinical association of metabolic syndrome, C‐reactive protein and testosterone levels with clinically significant prostate cancer

The Role of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio, and Platelets in the Prognosis of Metastatic Renal Cell Carcinoma

Association between systemic inflammation and serum prostatespecific antigen in a healthy Korean population

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