Prognostic value of homocysteinemia in patients with congestive heart failure

Gibelin, P; Serre, Stephanie; Candito, M.; Houcher, Bakhouche; Berthier, F.; Baudouy, M

doi:10.1515/cclm.2006.138

Cited by 20 publications

(18 citation statements)

References 21 publications

(23 reference statements)

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“…Some studies have proposed a mechanism whereby a high homocysteine level could cause heart failure. Additionally, some studies have reported that vitamin supplementation, including folic acid supplementation, improved the potency of vasodilation and decreased blood pressure, 32,33) whereas others have suggested that such supplements are not effective. 6,34,35) Therefore, in addition to evaluating the long-term outcome of the subjects in this study, further studies on the possible benefits of vitamin supplementation are necessary.…”

Section: Limitationsmentioning

confidence: 99%

Relationship Between Plasma Homocysteine Levels and Congestive Heart Failure in Patients With Acute Myocardial Infarction Homocysteine and Congestive Heart Failure

et al. 2011

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SummaryHeart failure after acute myocardial infarction (AMI) is an important factor in determining clinical outcome. We examined whether the plasma homocysteine level was a predictor of heart failure in patients with AMI. A series of 96 patients without renal failure who were admitted to our hospital because of AMI between January 2003 and December 2005 were assigned to two groups; a group with a high homocysteine level (group H: n = 48) and a group with a low homocysteine level (group L: n = 48) based on a median homocysteine level. Congestive heart failure was defined as Killip Class II or higher at the time of admission or the development of congestive heart failure after hospitalization. The mean brain natriuretic peptide (BNP) level at the time of admission in group H was higher than that of group L (175.3 pg/mL versus 89.9 pg/mL; P = 0.068). The incidence of heart failure in group H was significantly higher than that in group L (43.7% versus 12.5%; P < 0.001, log-rank test; hazard ratio: 2.92). Multivariate Cox regression analysis indicated that a high plasma homocysteine level of 10.8 μmol/L or higher was a risk factor for the development of heart failure (HR: 7.175, P < 0.01). The plasma homocysteine level in patients with AMI may be related to the development of heart failure. (Int Heart J 2011; 52: 224-228)

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Section: Limitationsmentioning

confidence: 99%

Relationship Between Plasma Homocysteine Levels and Congestive Heart Failure in Patients With Acute Myocardial Infarction Homocysteine and Congestive Heart Failure

et al. 2011

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“…Since HL-1 cells are known to demonstrate the same phenotype as primary culture cardiomyocytes, we did not view this as a limitation. The duration of time for treatment in vitro (24 hours) was chosen since it is known that treatment of cells with receptor agonists for many minutes or hours resulted in a loss of cellular receptors (downregulation) 6. If downregulation is going to occur, it is likely to be captured within this period of time.…”

Section: Resultsmentioning

confidence: 99%

“…It is known that treatment of cells with receptor agonists for many minutes or hours results in a loss of cellular receptors (downregulation) 6. Hence, this treatment would have been sufficient to evoke receptor downregulation and variable G protein content if Hcy is, indeed, an agonist to GPCRs utilizing these G proteins.…”

Section: Discussionmentioning

confidence: 99%

Differential expression of Gs in a murine model of homocysteinemic heart failure

Vacek

Sen²,

Tyagi³

et al. 2008

VHRM

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High plasma homocysteine levels are a known risk factor in heart failure and sudden cardiac death. The G proteins, G s (stimulatory) and G i (inhibitory), are involved in calcium regulation; overexpression has pathological consequences. The aims of this study were to examine the differential expression of G s G protein and G i in the hearts of hyperhomocysteinemic (Hhcy) mice, and to determine if homocysteine (Hcy) acts as an agonist in cell culture to mediate the change in G protein isoforms. To create Hhcy, heterozygous cystathionine-β-synthase (CBS) knockout (KO) mice were used. Mice were sacrifi ced, hearts were excised, cardiac tissue homogenates were prepared, and Western blots were performed. The results suggested that G s G protein was downregulated in cardiac tissue of heterozygous CBS KO mice to 46% that of control hearts. However, the intracellular G i G protein content remained the same in heterozygous CBS KO mice. Transformed cardiomyocyte HL-1 cells were treated with varying concentrations of homocysteine. The results suggested no detectable differential G s and G i expression. This suggested that Hcy did not act as an agonist in vitro to alter G protein content, but that Hcy produced some other in vivo effects to incur these results.

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“…The presence of HHcy is associated with faster progression of coronary plaque (16) and higher probability for recurrent cardiovascular events (6,9). In myocardial infarction, HHcy is considered a predictive factor of mortality, independent of other predictive factors (4,17,18).…”

Section: Discussionmentioning

confidence: 99%

Incidence of Hyperhomocysteinemia Among Patients With Acute Myocardial Infarction Younger Than 45 Years

Beletić¹,

Mirković²,

Antonijević³

et al. 2007

Journal of Medical Biochemistry

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Prognostic value of homocysteinemia in patients with congestive heart failure

Abstract: Elevated homocysteine levels observed in CHF patients, whatever the etiology of their heart disease (ischemic or non-ischemic), were correlated with the severity of the disease. Hyperhomocysteinemia appears to be a predictive factor of mortality in CHF patients.

Cited by 20 publications

References 21 publications

Relationship Between Plasma Homocysteine Levels and Congestive Heart Failure in Patients With Acute Myocardial Infarction Homocysteine and Congestive Heart Failure

Relationship Between Plasma Homocysteine Levels and Congestive Heart Failure in Patients With Acute Myocardial Infarction Homocysteine and Congestive Heart Failure

Differential expression of Gs in a murine model of homocysteinemic heart failure

Incidence of Hyperhomocysteinemia Among Patients With Acute Myocardial Infarction Younger Than 45 Years

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