Relationship Between Plasma Homocysteine Levels and Congestive Heart Failure in Patients With Acute Myocardial Infarction Homocysteine and Congestive Heart Failure

Abstract

SummaryHeart failure after acute myocardial infarction (AMI) is an important factor in determining clinical outcome. We examined whether the plasma homocysteine level was a predictor of heart failure in patients with AMI. A series of 96 patients without renal failure who were admitted to our hospital because of AMI between January 2003 and December 2005 were assigned to two groups; a group with a high homocysteine level (group H: n = 48) and a group with a low homocysteine level (group L: n = 48) based on a median homocysteine level. Congestive heart failure was defined as Killip Class II or higher at the time of admission or the development of congestive heart failure after hospitalization. The mean brain natriuretic peptide (BNP) level at the time of admission in group H was higher than that of group L (175.3 pg/mL versus 89.9 pg/mL; P = 0.068). The incidence of heart failure in group H was significantly higher than that in group L (43.7% versus 12.5%; P < 0.001, log-rank test; hazard ratio: 2.92). Multivariate Cox regression analysis indicated that a high plasma homocysteine level of 10.8 μmol/L or higher was a risk factor for the development of heart failure (HR: 7.175, P < 0.01). The plasma homocysteine level in patients with AMI may be related to the development of heart failure. (Int Heart J 2011; 52: 224-228)

Analysis of factors related to short-term prognosis in patients undergoing percutaneous coronary intervention for acute myocardial infarction

“…Consistent with previous reports (8,19–24), our data demonstrated that in the adverse events group the ages of the patients were higher than those in the control group and the proportion of females was significantly higher than that in the control group. The morbidity of hypertension in the adverse events group was higher than that in the control group and UA, HCY and CK levels, as well as CKMB enzyme peak were clearly higher than those in the control group.…”

“…A study has shown that with increasing age, the morbidities of hypertension and old myocardial infarction in AMI patients are significantly increased and the incidence rates of mechanical complications, arrhythmia and multivessel disease are also clearly higher than in younger patients (1,2). The hospital mortality rate of female AMI patients is significantly higher than that of males (3,4) and the increase of serum uric acid (UA) (5–7) and homocysteine (HCY) (8) increases the morbidity and mortality of cardiovascular diseases. Age, gender, blood pressure, lipid level and blood glucose are predictors influencing the outcome of AMI.…”

Methoxistasis: Integrating the Roles of Homocysteine and Folic Acid in Cardiovascular Pathobiology

“…Multiple small clinical studies have demonstrated that blood homocysteine levels are elevated in patients with heart failure compared to control population [81,82,83,84]. Blood homocysteine level is also related to the clinical severity of heart failure [85].…”

Selective homocysteine-lowering gene transfer attenuates pressure overload-induced cardiomyopathy via reduced oxidative stress

“…Furthermore, left ventricular diastolic function is significantly worse in hypertensive patients with elevated levels of homocysteine compared to hypertensive patients with normal homocysteine levels [3]. Finally, plasma homocysteine levels predict heart failure incidence in patients with or without prior myocardial infarction [4][5][6].…”