Prognostic value of HMGA2, P16, and HPV in oral squamous cell carcinomas

Loeschke, Siegfried; Ohlmann, Anne Katharina; Bräsen, Jan Hinrich; Holst, René; Warnke, Patrick H.

doi:10.1016/j.jcms.2016.06.009

Cited by 12 publications

(13 citation statements)

References 34 publications

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“…Furthermore, for OSCC patients, the OS of the P16-negative group was slightly higher than that of the P16-positive group, but not statistically significant (P = 0.343); these findings were consistent with findings from another study [26]. However, controversial results could be found with respect to the relationship between P16 status and the prognosis of OSCC [27][28][29], possibly due to individual differences, the strategy, and data that were lost to follow-up, suggesting that more systematic research is needed to verify these results. The Cox regression model revealed that the smoking index is an independent prognostic factor.…”

Section: Discussionsupporting

confidence: 85%

“…However, Loeschke et al. used Cox regression analysis to demonstrate that N stage was a prognostic factor.…”

Section: Discussionmentioning

confidence: 99%

“…The Cox regression model revealed that the smoking index is an independent prognostic factor. However, Loeschke et al [28] used Cox regression analysis to demonstrate that N stage was a prognostic factor.…”

Section: Discussionmentioning

confidence: 99%

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A systematic investigation of the association between HPV and the clinicopathological parameters and prognosis of oral and oropharyngeal squamous cell carcinomas

et al. 2017

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Human papillomavirus (HPV), the causal factor of cervical cancers, was closely linked to the etiology and prognosis of oropharyngeal squamous cell carcinoma (OPSCC), but its role in oral squamous cell carcinoma (OSCC) was unclear. In addition, few researches based on Chinese population were documented. Hence, we sought to investigate the relationship of HPV marker P16 protein to the clinicopathological parameters and survival of OPSCC and OSCC patients systematically to assess the influence of ethnic, regional difference on HPV susceptibility. Specimens from 93 OPSCC patients and 95 OSCC patients were recut, and P16 immunohistochemistry (IHC) was performed. Moreover, survival analysis was conducted to confirm the independent factors that influenced the prognosis. The P16 results were positive in 25.8% and 9.5% of patients with OPSCC and OSCC, respectively. The overall survival (OS) of HPV‐positive OPSCC patients was significantly longer than that of HPV‐negative OPSCC patients (P = 0.004). Conversely, statistical significance was not observed regarding the OS of OSCC patients (P = 0.343). Cox regression analysis indicated that T stage and P16 status were independent factors that affected the prognosis of OPSCC patients, and the smoking index influenced the prognosis of OSCC patients. Among OPSCC patients who received radiochemotherapy (RCT), HPV‐positive patients had a better survival rate than their HPV‐negative counterparts (P = 0.015). Conversely, no significant difference was observed between HPV‐positive and HPV‐negative OSCC patients who received RCT (P = 0.237). P16 is a credible surrogate by which to define HPV status. HPV expression had a favorable effect on OPSCC patients as opposed to their OSCC counterparts in this single center population‐based study.

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Section: Discussionsupporting

confidence: 85%

“…However, Loeschke et al. used Cox regression analysis to demonstrate that N stage was a prognostic factor.…”

Section: Discussionmentioning

confidence: 99%

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A systematic investigation of the association between HPV and the clinicopathological parameters and prognosis of oral and oropharyngeal squamous cell carcinomas

et al. 2017

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“…However, regarding its association with angiogenesis, only a few studies have shown that HMGA2 is required and sufficient to modulate angiogenesis in endothelial cells and endothelial progenitor cells [25,26]. Although, some reports described the importance of HMGA2 in the poor prognosis of oral cancer [27,28,29,30,31,32], its precise role in OSCC has not been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

HMGA2 Contributes to Distant Metastasis and Poor Prognosis by Promoting Angiogenesis in Oral Squamous Cell Carcinoma

Sakata

Hirosue

Yoshida

et al. 2019

IJMS

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The highly malignant phenotype of oral squamous cell carcinoma (OSCC), including the presence of nodal and distant metastasis, reduces patient survival. High-mobility group A protein 2 (HMGA2) is a non-histone chromatin factor that is involved in advanced malignant phenotypes and poor prognosis in several human cancers. However, its biological role in OSCC remains to be elucidated. The purpose of this study was to determine the clinical significance and role of HMGA2 in the malignant potential of OSCC. We first investigated the expression pattern of HMGA2 and its clinical relevance in 110 OSCC specimens using immunohistochemical staining. In addition, we examined the effects HMGA2 on the regulation of vascular endothelial growth factor (VEGF)-A, VEGF-C, and fibroblast growth factor (FGF)-2, which are related to angiogenesis, in vitro. High expression of HMGA2 was significantly correlated with distant metastasis and poor prognosis. Further, HMGA2 depletion in OSCC cells reduced the expression of angiogenesis genes. In OSCC tissues with high HMGA2 expression, angiogenesis genes were increased and a high proportion of blood vessels was observed. These findings suggest that HMGA2 plays a significant role in the regulation of angiogenesis and might be a potential biomarker to predict distant metastasis and prognosis in OSCC.

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“…HMGA proteins are non-histone, architectural chromatin proteins that have been found to have prognostic value in lung cancer [ 2 ], oral squamous cell carcinoma [ 44 , 45 ], ovarian cancer [ 8 ], breast cancer [ 46 ], and colorectal cancer [ 47 ] in terms of survival and recurrence rates. However, no previous studies have evaluated the prognostic value of HMGA2 overexpression in GC patients, which was the subject of our investigation.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological and prognostic significance of HMGA2 overexpression in gastric cancer: a meta-analysis

Zhu

Wang

et al. 2017

Oncotarget

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BackgroundHigh mobility group protein A2 (HMGA2) overexpression has been reported to be closely related to tumor progression [1-4] and indicate significantly worse overall survival in gastric cancer [5-8]. However, a final consensus regarding this issue has not yet been reached. Thus, we conducted a meta-analysis to evaluate the association between HMGA2 expression and prognosis of gastric cancer patients.MethodsThe Cochrane Library, Embase, PubMed, Web of Science and China Biology Medicine databases were searched to identify eligible literature published prior to September 2016. In the included studies, the level of HMGA2 amplification was evaluated by immunohistochemistry. We performed a meta-analysis, and pooled relative risk (RRs), hazard ratio (HRs), and 95% confidence intervals (CIs) were analyzed using Review Manager 5.3.ResultsSix studies [5-7, 9-11] involving 712 gastric cancer patients were included and stratified by HMGA2 amplification magnitude. The results of the analysis indicated that higher HMGA2 levels were associated with several clinicopathological parameters and predicted poor prognosis in terms of overall survival (OS).ConclusionsThe results of the present study indicate that higher HMGA2 levels were significantly associated with TNM stage, lymph node status, vascular invasion, and poor OS in patients with gastric cancer. In conclusion, HMGA2 may serve as a promising prognostic biomarker in gastric cancer.

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Prognostic value of HMGA2, P16, and HPV in oral squamous cell carcinomas

Cited by 12 publications

References 34 publications

A systematic investigation of the association between HPV and the clinicopathological parameters and prognosis of oral and oropharyngeal squamous cell carcinomas

A systematic investigation of the association between HPV and the clinicopathological parameters and prognosis of oral and oropharyngeal squamous cell carcinomas

HMGA2 Contributes to Distant Metastasis and Poor Prognosis by Promoting Angiogenesis in Oral Squamous Cell Carcinoma

Clinicopathological and prognostic significance of HMGA2 overexpression in gastric cancer: a meta-analysis

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