Clinicopathological and prognostic significance of HMGA2 overexpression in gastric cancer: a meta-analysis

Zhu, Jianwei; Wang, Hailong; Xu, Shuangnian; Hao, Ya

doi:10.18632/oncotarget.19001

Cited by 19 publications

(22 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been shown that HMGA2 regulates the expression of the potent fetal growth factor IGF2 linking the gene to the phenotype of growth restriction (Abi Habib et al, 2017). Somatic mutations in HMGA2 have been identified in various tumors such as uterine leiomyoma, gastric cancer or in pediatric lipoma (Lagana et al, 2017;Zhu et al, 2017;Dadone et al, 2015). In addition, genome-wide association studies identified common germline variants in HMGA2 to be associated with height in various populations in both children and adults (Weedon et al, 2007;Weedon et al, 2008;Lettre et al, 2008;Wood et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

A case report and review of the literature indicate that HMGA2 should be added as a disease gene for Silver-Russell syndrome

Leszinski

Warncke

Hoefele

et al. 2018

Gene

View full text Add to dashboard Cite

Patients with Silver-Russell syndrome (SRS), a syndromic growth retardation syndrome, usually harbor an epimutation at chromosome 11p15 or a maternal uniparental disomy of chromosome 7. However, to date the genetic cause remains unknown in around 40% of SRS cases, suggesting genetic heterogeneity and involvement of other genes. We present a 4-year-old female patient with the clinical diagnosis of SRS and negative results in common genetic SRS diagnostics. Whole exome sequencing identified a de novo heterozygous 7.3 kb deletion on chromosome 12q14.3 including exon 1 and 2 of HMGA2. HMGA2 encodes an architectural transcription factor and has already been linked to body size variations in various genome-wide association studies and mouse models. Reviewing the literature, we found additional four patients with a phenotype of SRS harboring point mutations or structural variants involving HMGA2. We conclude that genetic testing of HMGA2 should be considered in routine diagnostics in patients with the suspicion of SRS.

show abstract

Section: Discussionmentioning

confidence: 99%

A case report and review of the literature indicate that HMGA2 should be added as a disease gene for Silver-Russell syndrome

Leszinski

Warncke

Hoefele

et al. 2018

Gene

View full text Add to dashboard Cite

show abstract

“…Unlike previous studies that have focused on cancer cell-centric prognosis biomarkers, such as microRNA, lncRNA, or relative progression proteins, the present meta-analysis focused on biomarkers associated with immune cell interaction [ 3 , 35 , 36 ]. Immune effector molecules MICA/B not only reflect a distinct underlying biology of the tumor, but they are also involved in innate immune activation and cancer immune tolerance [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of MICA/B in cancers: a systematic review and meta-analysis

Zhao

Chen

et al. 2017

Oncotarget

View full text Add to dashboard Cite

PurposeMHC class I chain related-proteins A (MICA) and B (MICB) are natural killer group 2D ligands that mediate tumor surveillance. Several studies have suggested that MICA/B levels predict clinical outcomes in patients with cancer; however, this remains contentious. Here, we present a systematic review and meta-analysis of available studies of the prognostic value of MICA/B in cancer.Materials and MethodsWe searched PubMed, Embase, Clinicaltrials.gov, and Cochrane Library to identify studies published from inception to July 2017 that assessed MICA/B in patients with cancer. The hazard ratio (HR) and 95% confidence interval (CI) of MICA/B were extracted for overall survival (OS) analysis.ResultsA total of 19 studies comprising 2,588 patients with 10 different types of cancer were included in the study. Low sMICA/B levels were found associated with significantly longer OS (HR = 1.65, 95% CI [1.42–1.92], P < 0.00001). Patients with cancers of digestive system that exhibited high MICA/B expression had significantly longer OS in (HR = 0.56, 95% CI [0.39–0.80], P = 0.002) compared with those with lower MICA/B expression (I2 = 35%, P = 0.18).ConclusionsSerum soluble MICA/B represents a potential prognostic marker in various human cancers. High cell-surface MICA/B expression in cancers of the digestive system was found associated with increased survival.

show abstract

“…Moreover, HMGA2 has showed to be essential in regulating cell growth, proliferation, differentiation and death, in promoting adipocyte differentiation. Over-expression of HMGA2 has also been found in some tumoral tissues (uterine leiomyoma, gastric cancer, pediatric lipoma) [ 6 – 8 , 12 , 24 – 27 ]. These experimental studies, added to the clinical data reported in literature, converge in proving the key role of HMGA2 alterations in pre- and postnatal growth failure and failure to thrive that is otherwise unexplained.…”

Section: Discussionmentioning

confidence: 99%

12q14.3 microdeletion involving HMGA2 gene cause a Silver-Russell syndrome-like phenotype: a case report and review of the literature

et al. 2020

View full text Add to dashboard Cite

Background: Silver-Russell Syndrome (SRS) is a genetic disorder characterized by intrauterine and postnatal growth restriction and normal head circumference with consequent relative macrocephaly. Addictional findings are protruding forehead in early life, body asymmetry (of upper and lower limbs) and substantial feeding difficulties. Although several genetic mechanisms that cause the syndrome are known, more than 40% of patients with a SRSlike phenotype remain without an etiological diagnosis. In the last few years, different clinical reports have suggested that mutations or deletions of the HMGA2 gene can be responsible for a SRS-like phenotype in patients with negative results of the common diagnostic tests for this syndrome. Case presentation: We present a 3-year-old male patient with clinical diagnosis of Silver-Russell Syndrome (SRS) associated with a de novo heterozygous deletion of the long arm of the chromosome 12 (12q14.3) encompassing the HMGA2 gene. Conclusions: Our report confirms the etiological role of HMGA2 as a disease gene in the development of a SRS-like phenotype.

show abstract

Clinicopathological and prognostic significance of HMGA2 overexpression in gastric cancer: a meta-analysis

Cited by 19 publications

References 49 publications

A case report and review of the literature indicate that HMGA2 should be added as a disease gene for Silver-Russell syndrome

A case report and review of the literature indicate that HMGA2 should be added as a disease gene for Silver-Russell syndrome

Prognostic value of MICA/B in cancers: a systematic review and meta-analysis

12q14.3 microdeletion involving HMGA2 gene cause a Silver-Russell syndrome-like phenotype: a case report and review of the literature

Contact Info

Product

Resources

About