Prognostic value of MICA/B in cancers: a systematic review and meta-analysis

Zhao, Yijing; Chen, Naifei; Yu, Yu; Zhou, Lili; Niu, Chao; Liu, Yudi; Tian, Huimin; Lv, Zheng; Han, Fujun; Cui, Jiuwei

doi:10.18632/oncotarget.21466

Cited by 76 publications

(54 citation statements)

References 40 publications

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“…However, this diversity was due to the inability to discriminate soluble and membrane expressed ligands in histology. Today we know, that solely membrane-bound ligands on cancer cells are a positive predictor for patient survival ( 65 ). However, the levels of soluble stress-induced ligands in the serum cancer patients pose a valuable prognostic factor.…”

Section: Shedding-an Efficient Way To Evade From Nkg2d-mediated Survementioning

confidence: 99%

NKG2D Ligands–Critical Targets for Cancer Immune Escape and Therapy

2018

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DNA damage, oncogene activation and excessive proliferation, chromatin modulations or oxidative stress are all important hallmarks of cancer. Interestingly, all of these abnormalities also induce a cellular stress response. By upregulating “stress-induced ligands,” damaged or transformed cells can be recognized by immune cells and cleared. The human genome encodes eight functional “stress-induced ligands”: MICA, MICB, and ULBP1-6. All of them are recognized by a single receptor, NKG2D, which is expressed on natural killer (NK) cells, cytotoxic T cells and other T cell subsets. The NKG2D ligand/NKG2D-axis is well-recognized as an important mediator of anti-tumor activity; however, patient data about the role of NKG2D ligands in immune surveillance and escape appears conflicting. As these ligands are often actively transcribed, tumor cells are urged to manipulate the expression of these ligands on post-transcriptional or post-translational level. Although our knowledge on the regulation of NKG2D ligand expression remains fragmentary, research of the past years revealed multiple cellular mechanisms that are adopted by tumor cells to reduce the expression of “stress-induced ligands” and therefore escape immune recognition. Here, we review the post-transcriptional and post-translational mechanisms by which NKG2D ligands are modulated in cancer cells and their impact on patient prognosis.We discuss controversies and approaches to apply our understanding of the NKG2D ligand/NKG2D-axis for cancer therapy.

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Section: Shedding-an Efficient Way To Evade From Nkg2d-mediated Survementioning

confidence: 99%

NKG2D Ligands–Critical Targets for Cancer Immune Escape and Therapy

2018

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“…It is necessary to investigate the distribution of alkenylacyl-PC species further to estimate the healthiness of each tissue in pork, because plasmalogens may be involved in cancer or age-related neurodegenerative disorders, such as Alzheimer's disease or Parkinson's disease [11,12]. In addition, red meat containing pork has been reported as a potential cause of chronic diseases, such as colorectal cancer [3]. The literature has reported the utility of linear ion-trap multiple-stage mass spectrometry to analyze diacyl-, alkylacyl-, and alkenylacyl-PC species separately [9].…”

Section: Discussionmentioning

confidence: 99%

“…Consumer choice regarding meat consumption is influenced by the quality of the product, which is generally described by four parameters: Satisfaction, serviceability, security, and healthiness [1][2][3]. Healthiness, or nutritional quality, has become increasingly important due to a growing knowledge of how food components affect our physical and mental well-being.…”

Section: Introductionmentioning

confidence: 99%

Unique Distribution of Diacyl-, Alkylacyl-, and Alkenylacyl-Phosphatidylcholine Species Visualized in Pork Chop Tissues by Matrix-Assisted Laser Desorption/Ionization–Mass Spectrometry Imaging

Enomoto

Furukawa

Takeda

et al. 2020

Foods

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Phosphatidylcholine (PC) is the major phospholipid in meat and influences meat qualities, such as healthiness. PC is classified into three groups based on the bond at the sn-1 position: Diacyl, alkylacyl, and alkenylacyl. To investigate their composition and distribution in pork tissues, including longissimus thoracis et lumborum (loin) spinalis muscles, intermuscular fat, and transparent tissues, we performed matrix-assisted laser desorption/ionization–mass spectrometry imaging (MALDI–MSI). Eleven diacyl-, seven alkylacyl-, and six alkenylacyl-PCs were identified using liquid chromatography (LC)-tandem MS (MS/MS) analysis. Despite many alkylacyl- and alkenylacyl-PC species sharing identical m/z values, we were able to visualize these PC species using MALDI–MSI. Diacyl- and alkylacyl- and/or alkenylacyl-PC species showed unique distribution patterns in the tissues, suggesting that their distribution patterns were dependent on their fatty acid compositions. PCs are a major dietary source of choline in meat, and the amount was significantly higher in the muscle tissues. Consumption of choline mitigates age-related memory decline and neurodegenerative diseases; therefore, the consumption of pork muscle tissues could help to mitigate these diseases. These results support the use of MALDI–MSI analysis for assessing the association between PC species and the quality parameters of meat.

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“…Similarly, it has been recently found that increased expression of MICB could be considered a good prognostic factor for OS for patients with breast cancer [64]. Interestingly, only the membrane-bound form of the ligands has been associated with a positive survival prognosis for patients [108].…”

Section: Nk-mediated Immune Surveillance and Mirnas Involved In Immunmentioning

confidence: 90%

microRNAs in the Antitumor Immune Response and in Bone Metastasis of Breast Cancer: From Biological Mechanisms to Therapeutics

Maroni

Banfi

Lombardi

2020

IJMS

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Breast cancer is the most common type of cancer in women, and the occurrence of metastasis drastically worsens the prognosis and reduces overall survival. Understanding the biological mechanisms that regulate the transformation of malignant cells, the consequent metastatic transformation, and the immune surveillance in the tumor progression would contribute to the development of more effective and targeted treatments. In this context, microRNAs (miRNAs) have proven to be key regulators of the tumor-immune cells crosstalk for the hijack of the immunosurveillance to promote tumor cells immune escape and cancer progression, as well as modulators of the metastasis formation process, ranging from the preparation of the metastatic site to the transformation into the migrating phenotype of tumor cells. In particular, their deregulated expression has been linked to the aberrant expression of oncogenes and tumor suppressor genes to promote tumorigenesis. This review aims at summarizing the role and functions of miRNAs involved in antitumor immune response and in the metastasis formation process in breast cancer. Additionally, miRNAs are promising targets for gene therapy as their modulation has the potential to support or inhibit specific mechanisms to negatively affect tumorigenesis. With this perspective, the most recent strategies developed for miRNA-based therapeutics are illustrated.

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Prognostic value of MICA/B in cancers: a systematic review and meta-analysis

Cited by 76 publications

References 40 publications

NKG2D Ligands–Critical Targets for Cancer Immune Escape and Therapy

NKG2D Ligands–Critical Targets for Cancer Immune Escape and Therapy

Unique Distribution of Diacyl-, Alkylacyl-, and Alkenylacyl-Phosphatidylcholine Species Visualized in Pork Chop Tissues by Matrix-Assisted Laser Desorption/Ionization–Mass Spectrometry Imaging

microRNAs in the Antitumor Immune Response and in Bone Metastasis of Breast Cancer: From Biological Mechanisms to Therapeutics

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