Prognostic value of high plasma brain natriuretic peptide concentrations in very elderly persons

Ueda, Ryuji; Yokouchi, Masatoshi; Suzuki, Taiji; Otomo, E; Kubo, Takashi

doi:10.1016/s0002-9343(02)01525-5

Cited by 61 publications

(48 citation statements)

References 18 publications

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“…The increases in CNHs with aging may be attributable to the paraphysiologic decrease in myocardial function and other organs, including the kidney, that is typical of senescence (24 ). In this case, CNH assays may be considered as biochemical markers of increased risk of cardiac morbidity in old age (25 ). Moreover, the increase in CNHs with aging may be attributable to a decrease in their clearance rate.…”

Section: Pathophysiologic Relevance Of the Cnh Systemmentioning

confidence: 99%

“…diagnostic accuracy of cnh assays in the elderly HF is primarily a disease of old age. The authors of some recent studies have reported that BNP assays could be clinically useful in elderly people suspected to have HF (25,36 ). In particular, a prospective cohort study specifically evaluated the diagnostic accuracy for HF of BNP assays in 299 consecutive patients (mean age, 79 years; 65% women) attending a day-hospital over a period of 13 months (36 ).…”

Section: Diagnostic Accuracy Of Cnh Assays In Patients With Acute Myomentioning

confidence: 99%

“…Two studies specifically investigated whether CNH assays can predict mortality in elderly persons (25,92 ). Wallen et al (92 ) studied the relationship of BNP concentrations with aging and whether BNP could reflect current disease states in the general elderly population (545 individuals Ͼ85 years of age).…”

Section: Prognosis In Hfmentioning

confidence: 99%

“…Furthermore, over recent years, several well-designed studies demonstrated the prognostic relevance of CNH assays in patients with both HF (25,33,(87)(88)(89)(90)(91)(92) and ACS (33-35, 38, 60, 72, 86, 94 -107 ). Currently, use as prognostic markers seems to be the main indication for CNH assays.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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Diagnostic Accuracy and Prognostic Relevance of the Measurement of Cardiac Natriuretic Peptides: A Review

2004

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Background:The pathophysiologic and clinical relevance of cardiac natriuretic hormone (CNH) assays has been investigated in numerous experimental and clinical studies. Authors have sought to evaluate the diagnostic accuracy and prognostic relevance of the measurement of CNHs according to evidence-based laboratory medicine principles. Methods: In June 2003, we ran a computerized literature search on National Library of Medicine using keywords "ANP" and "BNP" and found more than 12 300 and 1200 articles, respectively. A more refined search with keywords "ANP or BNP assay" extracted ϳ7000 and 800 articles, respectively. Only studies specifically designed to evaluate the diagnostic accuracy and prognostic relevance of CNH measurements were selected from this huge mass of articles to be discussed in this review. Content: Several studies suggested that CNH assays may be clinically useful for the screening and classification of patients with heart failure, as a prognostic marker in cardiovascular disease, in the follow-up of patients with heart failure, and because they may reduce the need for further cardiac investigation. However, it is difficult to compare even the best-designed studies because not only did the authors evaluate different populations, they also used different gold standards. Conclusions: CNH assays and conventional diagnostic work-ups provide complementary information for evaluation of the presence and severity of cardiac dysfunction and clinical disease. Several aspects of CNH assays are still to be elucidated, and further work is needed to

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Section: Pathophysiologic Relevance Of the Cnh Systemmentioning

confidence: 99%

Section: Diagnostic Accuracy Of Cnh Assays In Patients With Acute Myomentioning

confidence: 99%

Section: Prognosis In Hfmentioning

confidence: 99%

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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Diagnostic Accuracy and Prognostic Relevance of the Measurement of Cardiac Natriuretic Peptides: A Review

2004

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“…Moreover, in very elderly persons, the plasma brain natriuretic peptide concentration increases and may be a predictor of both cardiac disorders and mortality (18). These findings suggest that the increase of PASP and the level of brain natriuretic peptides may both be caused by the same events, which have yet to be determined.…”

Section: Discussionmentioning

confidence: 93%

Pulmonary Artery Systolic Pressure is Elevated in the Elderly: Relationships between Echocardiographic and Pathological Findings

et al. 2004

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Objective We investigated the relationship between the right cardiac system and increased pulmonary artery systolic pressure (PASP) in the elderly.Patients and Methods Echocardiography stable state data were available for 163 of 200 consecutive autopsied patients. Of these, PASP could be estimated by extrapolation from the maximum pressure gradient in tricuspid valve regurgitation from echocardiograms in 73 cases; however, 22 cases with secondary changes attributable to left cardiac insufficiency had to be excluded. We studied the remaining 51 patients in detail (16 men, 35 women, age 68-103 years; mean, 87.7±8.1). We investigated the following: echocardiographic and pathologic variables, age, sex, body mass index, the survival time (from echocardiography to autopsy), and the presence or absence of chronic pulmonary disease.Results

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Outpatient Evaluation for Cardiovascular Diseases Using Natriuretic Peptide Testing

Baggish¹,

Januzzi²

2007

Markers in Cardiology

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Prognostic value of high plasma brain natriuretic peptide concentrations in very elderly persons

Cited by 61 publications

References 18 publications

Diagnostic Accuracy and Prognostic Relevance of the Measurement of Cardiac Natriuretic Peptides: A Review

Diagnostic Accuracy and Prognostic Relevance of the Measurement of Cardiac Natriuretic Peptides: A Review

Pulmonary Artery Systolic Pressure is Elevated in the Elderly: Relationships between Echocardiographic and Pathological Findings

Outpatient Evaluation for Cardiovascular Diseases Using Natriuretic Peptide Testing

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