Prognostic Value of Hematologic Parameters in Patients with Metastatic Renal Cell Carcinoma Using Tyrosine Kinase Inhibitors

Abstract

This study showed that increased pretreatment NLR is an independent prognostic factor for patients with metastatic RCC using tyrosine kinase inhibitors.

Neutrophil to lymphocyte ratio is an independent prognostic factor in patients with recurrent or metastatic head and neck squamous cell cancer

“…Nakano et al (9) investigated the association between NLR and survival outcome in preoperative local and locally advanced breast cancer and concluded that it may be an independent prognostic factor for disease-free survival and breast cancer-specific survival in patients with breast cancer. It has also been demonstrated that increased pretreatment NLR is an independent prognostic factor in patients with metastatic renal cell carcinoma who received tyrosine kinase inhibitors (14).…”

“…Neutrophilia may inhibit the immune system by suppressing lymphocytes, activated T cells and natural killer cells (3,17). The prognostic role of the NLR has been evaluated in >60 studies on a number of solid tumors (7)(8)(9)(10)(11)(12)(13)(14)16,18).…”

“…NLR was reported to be an independent prognostic factor for patients with various types of cancer. An increase in NLR has been shown to be associated with adverse overall survival (OS) in several solid tumors (3); a high NLR was associated with adverse outcomes of nasopharyngeal carcinoma, castration-resistant metastatic prostate carcinoma, breast cancer, non-small-cell lung cancer (NSCLC), local and advanced esophageal squamous carcinoma and renal cell carcinoma (7)(8)(9)(10)(11)(12)(13)(14).…”

Treatment of Metastatic Colorectal Cancer With or Without Bevacizumab: Can the Neutrophil/Lymphocyte Ratio Predict the Efficiency of Bevacizumab?

“…Moreover, the morbidity and cost-effectiveness of this drug is also a problematic issue. The objective of this study was to evaluate the efficiency of bevacizumab in the first line treatment of mCRC patients when added to standard combination chemotherapy and to analyze the predictive role of clinicopathologic and biochemical parameters, including the neutrophil/lymphocyte ratio, shown to be relevant as a diagnostic or prognostic factors for many cancers (Unal et al, 2013;Zheng 2013;Cihan et al, 2014;Gunduz et al, 2014;Kacan et al, 2014;Kemal et al, 2014;Ozdemir et al, 2014).…”

Yüksek nötrofil- lenfosit oranının renal hücreli karsinomda preoperatif ve postoperatif dönemde sağkalıma etkisi

“…C-reactive protein, neutrophil or platelet count which correlates with systemic inflammation has been shown as a prognostic factor in different cancer types. Various studies have shown that high NLR is a poor prognostic factor such as in pancreatic, colorectal, lung, breast cancers (6)(7)(8)(9)). An increased neutrophillymphocyte ratio (NLR) has been proposed as a marker to predict the prognosis of RCC patients and many studies found preoperative NLR as a poor prognostic marker in RCC (10)(11)(12)(13)(14).…”