Neutrophil to lymphocyte ratio is an independent prognostic factor in patients with recurrent or metastatic head and neck squamous cell cancer

Salim, Derya Kivrak; Mutlu, Hasan; Eryılmaz, Melek Karakurt; Salim, Ozan; Musri, Fatma Yalcin; Tural, Deniz; Gündüz, Şeyda; Çoşkun, Hasan Şenol

doi:10.3892/mco.2015.557

Cited by 33 publications

(22 citation statements)

References 18 publications

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“…Finally, 25 studies with 28 cohorts fulfilled the criteria and were eligible in this meta‐analysis. All of them are retrospective observation studies.…”

Section: Resultsmentioning

confidence: 99%

High pretreatment neutrophil‐to‐lymphocyte ratio as a predictor of poor survival prognosis in head and neck squamous cell carcinoma: Systematic review and meta‐analysis

et al. 2018

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Background The prognostic roles of neutrophil‐to‐lymphocyte ratio (NLR) and platelet‐to‐lymphocyte ratio (PLR) have been reported in head and neck squamous cell carcinoma (HNSCC), but their results remain controversial. Methods A total of 25 literatures with 28 cohorts involving 6847 HNSCC patients were included. The hazard ratio (HR) was pooled with 95% confidence interval (CI) using fixed‐effects or random‐effects models. Results High pretreatment NLR predicted poor overall survival (OS: HR = 1.68; 95% CI = 1.39‐2.03; P < .001), disease‐free survival (DFS: HR = 1.76; 95% CI = 1.42‐2.17; P < .001), progression‐free survival (PFS: HR = 1.53; 95% CI = 1.09‐2.14; P = .014), and cancer‐specific survival (CSS: HR = 1.45; 95% CI = 1.23‐1.71; P < .001) in HNSCC. However, the association between PLR and OS or DFS was not statistically significant. Conclusion The NLR can serve as a potential prognostic biomarker for patients with HNSCC.

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“…Finally, 25 studies with 28 cohorts fulfilled the criteria and were eligible in this meta‐analysis. All of them are retrospective observation studies.…”

Section: Resultsmentioning

confidence: 99%

High pretreatment neutrophil‐to‐lymphocyte ratio as a predictor of poor survival prognosis in head and neck squamous cell carcinoma: Systematic review and meta‐analysis

et al. 2018

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“…The PRISMA flow chart of the systematic review can be found in Figure . An initial search done using the search strategy (Supporting Materials) obtained an initial 900 results.…”

Section: Methodsmentioning

confidence: 99%

Neutrophil‐to‐lymphocyte ratio as a prognostic indicator in head and neck cancer: A systematic review and meta‐analysis

et al. 2018

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“…The NLR is a well-known marker of inflammation. Recent studies stressed that an elevated NLR increased the risk of recurrence and distant metastasis and that it was therefore associated with a poor prognosis in head, neck, and thyroid cancers (Lang et al, 2014;Haddad et al, 2015;Salim et al, 2015). A previous study suggested that an increased NLR indicated an increased risk of metastasis in NPC (Jin et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Can Platelet and Leukocyte Indicators Give Us an Idea about Distant Metastasis in Nasopharyngeal Cancer?

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et al. 2017

Prague Med. Rep.

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Abstract:This study aimes to evaluate platelet and leucocyte indicators, such as the mean platelet volume, platelet distribution width, plateletcrit, white blood cell count, neutrophil to lymphocyte ratio in nasopharyngeal cancer patients and also to evaluate the relationship between these indicators and nasopharyngeal cancer with distant metastasis. The medical records of 118 patients diagnosed with nasopharyngeal cancer in our hospital between January 2006 and August 2015 were reviewed. The nasopharyngeal cancer group was further sub grouped according to the presence or absence of distant metastasis and TNM (tumour -T, node -N, metastasis -M) classification. A control group consisted of 120 healthy patients. The platelet and leucocyte values at the time of the initial diagnosis were recorded. Neutrophil to lymphocyte ratio and platelet distribution width values were significantly higher in the nasopharyngeal cancer group. But only platelet distribution width values were significantly higher in the nasopharyngeal cancer group with distant metastasis compared to the nasopharyngeal cancer group without distant metastasis. Neutrophil to lymphocyte ratio and platelet distribution width values may increase in nasopharyngeal cancer. But only the platelet distribution width values may give us an idea about the distant metastasis in nasopharyngeal cancer.

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Neutrophil to lymphocyte ratio is an independent prognostic factor in patients with recurrent or metastatic head and neck squamous cell cancer

Cited by 33 publications

References 18 publications

High pretreatment neutrophil‐to‐lymphocyte ratio as a predictor of poor survival prognosis in head and neck squamous cell carcinoma: Systematic review and meta‐analysis

High pretreatment neutrophil‐to‐lymphocyte ratio as a predictor of poor survival prognosis in head and neck squamous cell carcinoma: Systematic review and meta‐analysis

Neutrophil‐to‐lymphocyte ratio as a prognostic indicator in head and neck cancer: A systematic review and meta‐analysis

Can Platelet and Leukocyte Indicators Give Us an Idea about Distant Metastasis in Nasopharyngeal Cancer?

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