Prognostic Value of Global Longitudinal Strain in Hypertrophic Cardiomyopathy

Tower‐Rader, Albree; Mohananey, Divyanshu; To, Andrew; Lever, Harry M.; Popović, Zoran B.; Desai, Milind Y.

doi:10.1016/j.jcmg.2018.07.016

Cited by 117 publications

(70 citation statements)

References 33 publications

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“…An overlap with the phenotype of LV non-compaction (LVNC) is being discussed. Abnormal global longitudinal strain is a marker for an impaired prognosis [ 246 ].…”

Section: Myocarditis and Other Cardiomyopathiesmentioning

confidence: 99%

SCMR Position Paper (2020) on clinical indications for cardiovascular magnetic resonance

Leiner

Bogaert

Friedrich

et al. 2020

Journal of Cardiovascular Magnetic Resonance

209

110

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The Society for Cardiovascular Magnetic Resonance (SCMR) last published its comprehensive expert panel report of clinical indications for CMR in 2004. This new Consensus Panel report brings those indications up to date for 2020 and includes the very substantial increase in scanning techniques, clinical applicability and adoption of CMR worldwide. We have used a nearly identical grading system for indications as in 2004 to ensure comparability with the previous report but have added the presence of randomized controlled trials as evidence for level 1 indications. In addition to the text, tables of the consensus indication levels are included for rapid assimilation and illustrative figures of some key techniques are provided.

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“…An overlap with the phenotype of LV non-compaction (LVNC) is being discussed. Abnormal global longitudinal strain is a marker for an impaired prognosis [ 246 ].…”

Section: Myocarditis and Other Cardiomyopathiesmentioning

confidence: 99%

SCMR Position Paper (2020) on clinical indications for cardiovascular magnetic resonance

Leiner

Bogaert

Friedrich

et al. 2020

Journal of Cardiovascular Magnetic Resonance

209

110

View full text Add to dashboard Cite

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“…Currently, left ventricular global longitudinal strain (GLS) using speckle tracking echocardiography is the most ubiquitously used strain parameter in HCM (online supplementary figure 2). 39 In a recent systemic review of 14 observational studies in patients with HCM (n=3154), we found a clear association between abnormal LV GLS with adverse cardiac outcomes including mortality, appropriate ICD discharge and ventricular arrhythmias. A barrier to the routine use of LV GLS for clinical decision making is the lack of prospective evaluations to confirm its utility in HCM 39.…”

Section: Introductionmentioning

confidence: 78%

“…39 In a recent systemic review of 14 observational studies in patients with HCM (n=3154), we found a clear association between abnormal LV GLS with adverse cardiac outcomes including mortality, appropriate ICD discharge and ventricular arrhythmias. A barrier to the routine use of LV GLS for clinical decision making is the lack of prospective evaluations to confirm its utility in HCM 39. Furthermore, there are variations in the normal reference ranges in part contributed by the lack of standardisation between various echocardiography platforms.…”

Section: Introductionmentioning

confidence: 78%

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Advanced imaging for risk stratification of sudden death in hypertrophic cardiomyopathy

Ramchand

Fava

Chetrit

et al. 2020

Heart

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Hypertrophic cardiomyopathy (HCM) is a common inherited cardiac condition, which typically manifests as left ventricular hypertrophy. A small subset of patients with HCM have an increased risk of sudden cardiac death (SCD) from ventricular arrhythmias. Risk of SCD can be effectively reduced following implantation of implantable cardiac defibrillators (ICD), although this treatment carries a risk of complications such as inappropriate shocks. With this in mind, we turn to advances in cardiac imaging to guide risk stratification for SCD and to select the appropriate individual who may benefit from ICD implantation. In this review, we have taken the opportunity to briefly summarise the role of imaging in the diagnosis of HCM before focusing on how specific imaging features influence risk of SCD in patients with HCM.

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“…Beside well-established echocardiographic risk factors, there are novel echo parameters derived from 2D STE analysis that may provide additional insight in SCD risk stratification. In a study on more than 3000 HCM patients, abnormal GLS was associated with VA [48]. Mechanical dispersion (i.e., the standard deviation of the time from the onset of systole to maximum contraction for each of the myocardial segments, an expression of heterogeneous contraction and electrical activation) relates to the extent of fibrosis (assessed by CMR) and is an independent predictor of VA (Fig.…”

Section: Assessing the Risk Of Sudden Cardiac Deathmentioning

confidence: 99%

The role of echocardiography for diagnosis and prognostic stratification in hypertrophic cardiomyopathy

et al. 2020

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Hypertrophic cardiomyopathy (HCM) is the most frequent cardiac disease with genetic substrate, affecting about 0.2-0.5% of the population. While most of the patients with HCM have a relatively good prognosis, some are at increased risk of adverse events. Identifying such patients at risk is important for optimal treatment and follow-up. While clinical and electrocardiographic information plays an important role, echocardiography remains the cornerstone in assessing patients with HCM. In this review, we discuss the role of echocardiography in diagnosing HCM, the key features that differentiate HCM from other diseases and the use of echocardiography for risk stratification in this setting (risk of sudden cardiac death, heart failure, atrial fibrillation and stroke). The use of modern echocardiographic techniques (deformation imaging, 3D echocardiography) refines the diagnosis and prognostic assessment of patients with HCM. The echocardiographic data need to be integrated with clinical data and other information, including cardiac magnetic resonance, especially in challenging cases or when there is incomplete information, for the optimal management of these patients.

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Prognostic Value of Global Longitudinal Strain in Hypertrophic Cardiomyopathy

Abstract: Our systematic review of more than 3000 HCM patients suggests an association of abnormal LV-GLS with adverse composite cardiac outcomes and ventricular arrhythmias.

Cited by 117 publications

References 33 publications

SCMR Position Paper (2020) on clinical indications for cardiovascular magnetic resonance

SCMR Position Paper (2020) on clinical indications for cardiovascular magnetic resonance

Advanced imaging for risk stratification of sudden death in hypertrophic cardiomyopathy

The role of echocardiography for diagnosis and prognostic stratification in hypertrophic cardiomyopathy

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