Prognostic value of global longitudinal strain in hypertrophic cardiomyopathy: A systematic review and meta‐analysis

Yang, Ying; Wu, Dong; Wang, Hui; Wang, Yanting

doi:10.1002/clc.23928

Cited by 11 publications

(6 citation statements)

References 35 publications

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“…32 A meta-analysis that included 2441 patients confirmed the role of global longitudinal strain in predicting the outcome and risk stratification of HCM patients. 33 Even after septal myectomy, global longitudinal strain predicted worse survival rates;…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the prognostic value of papillary muscle‐free strain in patients with hypertrophic cardiomyopathy

Koyuncu,

Yildiz,

Oflar

et al. 2024

Echocardiography

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BackgroundThe prognosis of hypertrophic cardiomyopathy (HCM) varies from mild disease with a normal life expectancy to heart failure and sudden cardiac death (SCD). The identification of patients who are at high risk for SCD remains challenging.AimsIn this study, we evaluated the prognostic value of papillary muscle‐free strain in HCM patients.Methods and ResultsSeventy‐nine patients with a diagnosis of HCM were included in this study. Patients were divided into low/intermediate‐risk (n = 57) and high‐risk (n = 22) groups. Two‐dimensional (2‐D) echocardiography and strain imaging were performed for each patient. The mean age of the study population was 53.85 ± 15.88 years; 47 (59.5%) of them were male. During a mean follow‐up duration of 74.45 ± 17.03 months, 12 patients died. A comparison of the low‐intermediate and high‐SCD risk groups revealed that patients in the high‐SCD risk group had greater maximal wall thickness, interventricular septum thickness, posterior wall thickness, and left ventricular mass index (LVMI) and lower (less negative) global longitudinal, anterolateral papillary muscle (ALPM) and posteromedial papillary muscle (PMPM) free strain. Additionally, a history of syncope and ICD implantation were found to be more common in patients with high SCD risk scores. The SCD risk score was positively correlated with the global longitudinal strain, ALPM‐free strain, and PMPM‐free strain (r = .528, r = .658, and r = .600, respectively; p < .001 for all). Our results showed that the LVMI, presence of syncope, global longitudinal strain, and ALPM‐free strain were predictors of death.ConclusionsDecreased papillary muscle‐free strain values might have prognostic value in patients with HCM.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the prognostic value of papillary muscle‐free strain in patients with hypertrophic cardiomyopathy

Koyuncu,

Yildiz,

Oflar

et al. 2024

Echocardiography

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“…The follow-up duration extended for a period of 6 months, during which no attrition of clinical patients occurred. Throughout this follow-up period, the incidence of major adverse cardiovascular events (MACE) [11] was diligently recorded among AMI patients. Subsequently, patients were categorized into two distinct groups, namely the MACE group and the non-MACE group, based on the occurrence of these adverse events.…”

Section: Follow-upmentioning

confidence: 99%

The Value of Combined Detection of Serum BNP, Cardiac Troponin-I and Dynamic Electrocardiogram in Early Clinical Diagnosis and Prognosis of Patients with Acute Myocardial Infarction

Yu,

2024

Discovery Medicine

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Background: Acute myocardial infarction (AMI) is a prevalent cardiovascular disease resulting from myocardial ischemia and necrosis due to coronary artery occlusion. AMI is characterized by a sudden onset and high mortality, underscoring the significance of early diagnosis and treatment for improving patient prognosis. This study endeavors to assess the utility of a combined assessment involving serum brain natriuretic peptide (BNP), cardiac troponin-I (cTnI), and dynamic electrocardiogram (ECG) in the early clinical diagnosis and prognosis prediction of AMI. Methods: This paper constitutes a retrospective study. All enrolled patients underwent dynamic ECG examination. The study compared the serum levels of BNP and cTnI, along with pertinent dynamic ECG parameters [turbulence slope (TS) and standard deviation (SDNN) of the 24-hour interval between normal atrial depolarization and ventricular depolarization (R-R)], between the observation group (AMI patients) and the control group (patients with unstable angina (UA)). To evaluate the early diagnostic potential of AMI, we utilized receiver operating characteristic (ROC) curves to analyze serum BNP, cTnI, dynamic ECG, and their combined utility. Furthermore, a follow-up period of 6 months was conducted for AMI patients to record major adverse cardiovascular events (MACE). Results: In the observation group, the serum levels of BNP and cTnI were significantly higher than those in the control group (p < 0.001), while dynamic ECG parameters, specifically TS and SDNN, were significantly lower in the observation group compared to the control group (p < 0.001). The results obtained from the ROC curve analysis revealed that the area under the curve (AUC) for BNP, cTnI, dynamic ECG, and their combination in early AMI diagnosis were 0.838, 0.887, 0.874, and 0.974, respectively. The 95% confidence intervals (CI) were 0.781~0.884, 0.836~0.926, 0.822~0.915, and 0.942~0.991, respectively. Sensitivity values were 64.29%, 82.14%, 91.07%, and 88.39%, and specificity values were 91.00%, 88.00%, 70.00%, and 98.00%, respectively. Significantly, the combination of all three markers demonstrated superior efficacy in early AMI diagnosis compared to any single index (p < 0.05). During the 6-month follow-up of 112 AMI patients, 22 experienced MACE. The MACE group exhibited notably higher serum BNP and cTnI levels compared to the non-MACE group. Additionally, dynamic electrocardiogram parameters TS and SDNN demonstrated a significant decrease (p < 0.05) in the MACE group. Conclusions: The combined assessment of serum BNP, cTnI, and dynamic electrocardiogram enhances the early clinical diagnostic potential for AMI and holds value in assessing the prognosis of AMI patients.

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“…GLS has been used as an early marker of systolic dysfunction in genotype-positive phenotype-negative patients. It carries incremental prognostic value, being associated with adverse outcomes and progression to heart failure [37,38]. Moreover, pediatric studies on myocardial torsion have demonstrated an abnormal basal rotation with preserved or increased apical rotation [39].…”

Section: Echocardiography Application To Paediatric Cardiomyopathiesmentioning

confidence: 99%

The Role of Multimodality Imaging in Pediatric Cardiomyopathies

Moscatelli

Leo

Bianco³

et al. 2023

JCM

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Cardiomyopathies are a heterogeneous group of myocardial diseases representing the first cause of heart transplantation in children. Diagnosing and classifying the different phenotypes can be challenging, particularly in this age group, where cardiomyopathies are often overlooked until the onset of severe symptoms. Cardiovascular imaging is crucial in the diagnostic pathway, from screening to classification and follow-up assessment. Several imaging modalities have been proven to be helpful in this field, with echocardiography undoubtedly representing the first imaging approach due to its low cost, lack of radiation, and wide availability. However, particularly in this clinical context, echocardiography may not be able to differentiate from cardiomyopathies with similar phenotypes and is often complemented with cardiovascular magnetic resonance. The latter allows a radiation-free differentiation between different phenotypes with unique myocardial tissue characterization, thus identifying the presence and extent of myocardial fibrosis. Nuclear imaging and computed tomography have a complementary role, although they are less used in daily clinical practice due to the concern related to the use of radiation in pediatric patients. However, these modalities may have some advantages in evaluating children with cardiomyopathies. This paper aims to review the strengths and limitations of each imaging modality in evaluating pediatric patients with suspected or known cardiomyopathies.

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Prognostic value of global longitudinal strain in hypertrophic cardiomyopathy: A systematic review and meta‐analysis

Cited by 11 publications

References 35 publications

Evaluation of the prognostic value of papillary muscle‐free strain in patients with hypertrophic cardiomyopathy

Evaluation of the prognostic value of papillary muscle‐free strain in patients with hypertrophic cardiomyopathy

The Value of Combined Detection of Serum BNP, Cardiac Troponin-I and Dynamic Electrocardiogram in Early Clinical Diagnosis and Prognosis of Patients with Acute Myocardial Infarction

The Role of Multimodality Imaging in Pediatric Cardiomyopathies

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