Prognostic value of delta inflammatory biomarker-based nomograms in patients with inoperable locally advanced NSCLC

Guo, Meiying; Li, Wanlong; Li, Butuo; Zou, Bing; Wang, Shijiang; Meng, Xue; Sun, Xuejun; Yu, Jinming; Wang, Linlin

doi:10.1016/j.intimp.2019.04.032

Cited by 21 publications

(17 citation statements)

References 41 publications

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“…15 The delta in NLR >2.24 after chemoradiotherapy in NSCLC patients had a significantly worse OS and PFS (p<0.05 for each). 28 Together with those findings, our study adds to the growing body of literature supporting post-treatment and change in inflammatory factors as predictors of clinical outcomes in patients treated with SBRT. The molecular mechanisms underlying the relationships between high PLR and large change in NLR with poor prognosis in patients with HCC are not fully understood.…”

Section: Discussionsupporting

confidence: 69%

“…In addition, a research focused on non-small cell lung cancer (NSCLC) receiving chemoradiotherapy also proved that post-treatment and change in inflammatory biomarkers may have more prognostic significance than baseline measurements. 28 It is well known that as the most radiosensitive cells of the hematopoietic system, lymphocytes circulating through the radiation portal are frequently depleted. 17 Patients receiving SBRT may, therefore, experience a marked decrease in peripheral lymphocyte count and even lymphopenia.…”

Section: Discussionmentioning

confidence: 99%

“…The results are in line with previous observations of the predictive role of post-treatment and change in inflammation markers in different malignancies. 15,28 For example, an elevated post-PLR >290.0 was significantly associated with inferior OS (HR: 3.45; 95% CI: 1.17-10.17; p<0.05) in patients with liver cancer treated with SIRT. 15 The delta in NLR >2.24 after chemoradiotherapy in NSCLC patients had a significantly worse OS and PFS (p<0.05 for each).…”

Section: Discussionmentioning

confidence: 99%

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<p>Pre/Post-Treatment Dynamic of Inflammatory Markers Has Prognostic Value in Patients with Small Hepatocellular Carcinoma Managed by Stereotactic Body Radiation Therapy</p>

Zhuang

Yuan

et al. 2020

CMAR

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The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are inflammatory indexes that may reflect immune response to tumors and prognosis. We investigated the prognostic values of pre-treatment and post-treatment NLR and PLR and changes in those ratios in patients with small hepatocellular carcinoma (sHCC) treated with stereotactic body radiation therapy (SBRT). Patients and methods: Sixty patients who received SBRT were retrospectively reviewed. NLR and PLR were calculated by division of neutrophil and platelet counts, respectively, by lymphocyte counts. Independent factors for progression-free survival (PFS) and overall survival (OS) were determined by the Kaplan-Meier method, log-rank test, and Cox multivariate regression. Hazard ratios (HRs) and 95% confidence intervals (CIs) were also calculated. Results: The median follow-up was 36.9 (range: 4.1-73.5) months. Median PFS was 21.4 (range: 1.8-66.9) months. The 1-year and 2-year PFS rates were 76.7% and 55.0%, respectively. The 1-year and 2-year OS rates were 95.0% and 78.3%, respectively. In multivariate analysis, post-treatment PLR ≥263.0 indicated both poor PFS (HR: 3.70; 95% CI: 1.07-12.76, p=0.038) and OS (HR: 3.23; 95% CI: 1.01-9.11, p=0.043) for sHCC patients treated with SBRT. In addition, the presence of hepatitis infection and a low level of red blood cell count were also proved to be significantly associated with patients' poor prognosis (p<0.05 for each). Post-treatment increase in NLR ≥2.7-fold was shown to be a negative independent predictor of inferior OS (HR: 3.43; 95% CI: 1.14-10.38, p=0.029). Conclusion: High post-treatment PLR and change in NLR ≥2.7-fold were associated with poor prognosis in patients treated with SBRT and might be considered as reliable and independent prognostic biomarkers for patients with sHCC.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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<p>Pre/Post-Treatment Dynamic of Inflammatory Markers Has Prognostic Value in Patients with Small Hepatocellular Carcinoma Managed by Stereotactic Body Radiation Therapy</p>

Zhuang

Yuan

et al. 2020

CMAR

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“…According to univariate analysis, we found that delta NLR less than 0.18 had a significantly worse prognosis of EFS (p=0.0119, HR= 3.05, 95% CI, 1.28 to 7.28), in addition to pre-LMR also maintaining a significant relationship with EFS (p=0.0169, HR= 3.11, 95% CI, 1.23 to 7.90). Although these results did not prove to be significant in multivariate analysis, they are supported by current literature studying the use of delta inflammatory biomarkers in nonsmall-cell lung cancer (NSCLC) [34]. Delta NLR and pre-LMR were significantly associated with OS and progression-free survival (PFS), in both univariate and multivariate analysis in patients with NSCLC undergoing concurrent chemoradiotherapy.…”

Section: Discussionmentioning

confidence: 64%

“…In the past, the delta ratio has been used in other cancers such as colon cancer and has shown delta NLR to be an independent prognostic indicator of overall survival [20]. In addition, delta NLR has been shown to be an independent predictor of overall survival in patients with advanced non-small cell lung cancer [21]. Delta NLR has also proven itself to be a strong predictor in breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Relationship between Delta Inflammatory Markers and Prognosis in Head and Neck Squamous Cell Carcinoma

Khaymovich

Wong

et al. 2021

Preprint

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Purpose: Inflammatory markers, such as Lymphocyte-to-Monocyte Ratio (LMR), Neutrophil-to-Lymphocyte Ratio (NLR), and Platelet-to-Lymphocyte Ratio (PLR), have been shown to hold significant prognostic value in the context of head and neck cancer (HNC). Recently, delta inflammatory markers, the difference between pre and post- treatment inflammatory marker ratios, have been suggested as potentially significant values in predicting cancer prognosis. Our objective was to evaluate the prognostic utility of delta LMR, NLR, and PLR in head and neck squamous cell carcinoma (HNSCC). Methods: Retrospective cohort study in a tertiary academic hospital setting. Patients diagnosed with HNSCC in the oral cavity, larynx, and oropharynx treated with curative intent treatment were included. The variables collected were age, sex, BMI, alcohol/tobacco exposure, performance scores, ACE-27, tumor characteristics, adjuvant treatment, ECOG score, and lab values. Overall Survival (OS) and Event-Free Survival (EFS) were chosen as endpoints. OS was defined as time from date of treatment to date of last follow-up or death from any cause, and EFS was defined as the start of treatment to any progression, recurrence, or death from any cause. Univariate and multivariate analyses were performed on the primary endpoints. Results: A total of 89 patients were included from 2010 to 2017. In multivariate analysis, EFS was found to be significantly associated with an N stage of 3 (p=0.0005) and delta LMR > -1.48 (p=0.0241). No significant relationships were uncovered with OS in multivariate analysis. Conclusion: A higher delta LMR value (>-1.48) was associated with poorer EFS, but was not associated with OS.

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The Influence of Severe Radiation-Induced Lymphopenia on Overall Survival in Solid Tumors: A Systematic Review and Meta-Analysis

Damen¹,

Kroese²,

Hillegersberg³

et al. 2021

International Journal of Radiation Oncology*Biology*Physics

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Prognostic value of delta inflammatory biomarker-based nomograms in patients with inoperable locally advanced NSCLC

Cited by 21 publications

References 41 publications

<p>Pre/Post-Treatment Dynamic of Inflammatory Markers Has Prognostic Value in Patients with Small Hepatocellular Carcinoma Managed by Stereotactic Body Radiation Therapy</p>

<p>Pre/Post-Treatment Dynamic of Inflammatory Markers Has Prognostic Value in Patients with Small Hepatocellular Carcinoma Managed by Stereotactic Body Radiation Therapy</p>

Investigation of the Relationship between Delta Inflammatory Markers and Prognosis in Head and Neck Squamous Cell Carcinoma

The Influence of Severe Radiation-Induced Lymphopenia on Overall Survival in Solid Tumors: A Systematic Review and Meta-Analysis

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