The Influence of Severe Radiation-Induced Lymphopenia on Overall Survival in Solid Tumors: A Systematic Review and Meta-Analysis

Damen, P.; Kroese, Tiuri E.; Hillegersberg, Richard van; Schuit, Ewoud; Peters, Max; Verhoeff, Joost J.C.; Lin, Steven H.; Rossum, Peter S.N. van

doi:10.1016/j.ijrobp.2021.07.1695

Cited by 70 publications

(61 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the best objective responses in terms of size reduction according to RECIST were observed in patients with multiple measurable target lesions, apparently rejecting a direct link between number/size of the lesions and R-RIT effectiveness. Moreover, a negative correlation between radiation-induced lymphopenia and outcome has been reported in solid tumors [ 33 , 34 ]. In our cohort, the patient who exhibited the best response experienced a severe (G3) but transient lymphopenia.…”

Section: Discussionmentioning

confidence: 99%

ED-B-Containing Isoform of Fibronectin in Tumor Microenvironment of Thymomas: A Target for a Theragnostic Approach

Petrini

Sollini

Bartoli

et al. 2022

Cancers

View full text Add to dashboard Cite

Aim: to exploit tissue-specific interactions among thymic epithelial tumor (TETs) cells and extra-domain B fibronectin (ED-B FN). Material and methods: The stromal pattern of ED-B FN expression was investigated through tumor specimen collection and molecular profiling in 11 patients with recurrent TETs enrolled in prospective theragnostic phase I/II trials with Radretumab, an ED-B FN specific recombinant human antibody. Radretumab radioimmunotherapy (R-RIT) was offered to patients who exhibited the target expression. Experiments included immunochemical analysis (ICH), cell cultures, immunophenotypic analysis, Western blot, slot-blot assay, and quantitative RT-PCR of two primary thymoma cultures we obtained from patients’ samples and in the Ty82 cell line. Results: The in vivo scintigraphic demonstration of ED-B FN expression resulted in R-RIT eligibility in 8/11 patients, of which seven were treated. The best observed response was disease stabilization (n = 5/7) with a duration of 4.3 months (range 3–5 months). IHC data confirmed high ED-B FN expression in the peripherical microenvironment rather than in the center of the tumor, which was more abundant in B3 thymomas. Further, there was a predominant expression of ED-B FN by the stromal cells of the thymoma microenvironment rather than the epithelial cells. Conclusions: Our data support the hypothesis that thymomas induce stromal cells to shift FN production to the ED-B subtype, likely representing a favorable hallmark for tumor progression and metastasis. Collectively, results derived from clinical experience and molecular insights of the in vitro experiments suggested that R-RIT inefficacy is unlikely related to low target expression in TET, being the mechanism of R-RIT resistance eventually related to patients’ susceptibility (i.e., inherent characteristics), the pattern expression of the target (i.e., at periphery), the biological characteristics of the tumor (i.e., aggressive and resistant phenotypes), and/or to format of the target agent (i.e., 131I-L19-SIP).

show abstract

Section: Discussionmentioning

confidence: 99%

ED-B-Containing Isoform of Fibronectin in Tumor Microenvironment of Thymomas: A Target for a Theragnostic Approach

Petrini

Sollini

Bartoli

et al. 2022

Cancers

View full text Add to dashboard Cite

show abstract

“…Lymphopenia and treatment-induced reduction of lymphocytes as an immunological side effect of radiotherapy are emerging negative prognostic factors for multiple solid tumor entities 3. , 4. , 5.…”

Section: Discussionmentioning

confidence: 99%

“…Although the return of the circulating lymphocyte count to the baseline is usually rapid in the post-RT period, numerous recent studies on the clinical level have implicated a negative influence of RIL on the survival outcomes in patients bearing solid tumors 3. , 4. , 5.…”

Section: Introductionmentioning

confidence: 99%

Radiation-induced lymphopenia does not impact treatment efficacy in a mouse tumor model

et al. 2022

View full text Add to dashboard Cite

“…Radiation-induced lymphopenia (RIL) has been recently identified as a negative biomarker for patients. A recent meta-analysis reported that patients who experienced grade ≥3 lymphopenia after irradiation demonstrated an increased risk of death of 65%, compared to patients who did not [83]. Multiple factors have been reported to influence the risk of developing RIL, including patient age, sex, baseline absolute lymphocyte count (ALC), irradiated tumor volume and fractionation [49,50].…”

Section: Circulating Blood Cellsmentioning

confidence: 99%

Leveraging Blood-Based Diagnostics to Predict Tumor Biology and Extend the Application and Personalization of Radiotherapy in Liver Cancers

Hauth

Roberts

Hong

et al. 2022

IJMS

View full text Add to dashboard Cite

While the incidence of primary liver cancers has been increasing worldwide over the last few decades, the mortality has remained consistently high. Most patients present with underlying liver disease and have limited treatment options. In recent years, radiotherapy has emerged as a promising approach for some patients; however, the risk of radiation induced liver disease (RILD) remains a limiting factor for some patients. Thus, the discovery and validation of biomarkers to measure treatment response and toxicity is critical to make progress in personalizing radiotherapy for liver cancers. While tissue biomarkers are optimal, hepatocellular carcinoma (HCC) is typically diagnosed radiographically, making tumor tissue not readily available. Alternatively, blood-based diagnostics may be a more practical option as blood draws are minimally invasive, widely availability and may be performed serially during treatment. Possible blood-based diagnostics include indocyanine green test, plasma or serum levels of HGF or cytokines, circulating blood cells and genomic biomarkers. The albumin–bilirubin (ALBI) score incorporates albumin and bilirubin to subdivide patients with well-compensated underlying liver dysfunction (Child–Pugh score A) into two distinct groups. This review provides an overview of the current knowledge on circulating biomarkers and blood-based scores in patients with malignant liver disease undergoing radiotherapy and outlines potential future directions.

show abstract

The Influence of Severe Radiation-Induced Lymphopenia on Overall Survival in Solid Tumors: A Systematic Review and Meta-Analysis

Cited by 70 publications

References 93 publications

ED-B-Containing Isoform of Fibronectin in Tumor Microenvironment of Thymomas: A Target for a Theragnostic Approach

ED-B-Containing Isoform of Fibronectin in Tumor Microenvironment of Thymomas: A Target for a Theragnostic Approach

Radiation-induced lymphopenia does not impact treatment efficacy in a mouse tumor model

Leveraging Blood-Based Diagnostics to Predict Tumor Biology and Extend the Application and Personalization of Radiotherapy in Liver Cancers

Contact Info

Product

Resources

About