Prognostic Value of D-Dimer in Patients with Diffuse Large B-cell Lymphoma: A Retrospective Study

High pretreatment plasma D-dimer levels predict poor survival in patients with diffuse large B-cell lymphoma in the real world

“…(1.6 μg/mL) but much greater than that reported by Geng et al (0.92 μg/mL) (16). The low cut-off value reported by Geng et al might classify the subset of patients with DLBCL with low plasma D-dimer level and good prognosis into a group with high plasma D-dimer level, leading to a reduction in the discrimination efficiency of the cut-off value (16).…”

“…Liu et al found that higher pretreatment plasma D-dimer level was negatively associated with OS and an independent prognostic factor for worse OS among untreated patients with DLBCL ( 17 ). Geng et al found that higher pretreatment plasma D-dimer level was associated with some clinicopathological factors, such as advanced Ann Arbor stage (III–IV) and high LDH level (> ULN), and was negatively associated with OS, but was not an independent poor prognostic factor among untreated patients with DLBCL ( 16 ).…”

“…Several studies have shown that elevated pretreatment plasma D-dimer levels were predictors of poor survival in various types of solid tumor (9)(10)(11)(12)(13)(14)(15). However, only few studies have assessed the prognostic role of pretreatment plasma D-dimer level in DLBCL (16,17). Thus, we retrospectively analyzed data of patients with DLBCL at our hospital, aiming to explore the relationship between pretreatment plasma D-dimer levels and the prognosis of patients with DLBCL and to evaluate the prognostic value of pretreatment plasma D-dimer level.…”

Diagnostic Value of Serum D-Dimer for Detection of Gallbladder Carcinoma

“…[10][11][12][13][14][15] Recent studies have shown that D-dimers are dysregulated in many different types of cancers, including gastric cancer, musculoskeletal sarcoma, lung cancer, pancreatic cancer, esophageal squamous cell carcinoma, ovarian cancer, nasopharyngeal cancer, liver cancer, lymphoma, spinal giant cell tumor, and breast cancer. 6,7,[16][17][18][19][20][21][22][23][24][25][26] Moreover, several studies have shown that elevated levels of D-dimer are significantly associated with cancer recurrence, metastasis, and worse survival outcome. 6,17,[24][25][26] However, to date, no one has studied the diagnostic value of D-dimer in gallbladder carcinoma.…”

Correlation of 18F-FDG PET/CT SUVmax with clinical features, D-dimer and LDH in patients with primary intestinal lymphoma

“…It is used to monitor the diagnosis and condition of disseminated intravascular coagulation and thrombophilia. 23 Patients with malignant lymphoma have recently been found to exhibit a hypercoagulable state, dysfunction of the fibrinolytic system and a higher incidence of venous thrombosis. 24 Related reports suggest that the incidence of deep vein thrombosis in patients with NHL is 5.77%.…”