High pretreatment plasma D-dimer levels predict poor survival in patients with diffuse large B-cell lymphoma in the real world

Huang, Haobo; Fan, Liping; Fu, Danhui; Lin, Qiuyan; Shen, Jian-Zhen

doi:10.21037/tcr-20-2908

Cited by 4 publications

(7 citation statements)

References 30 publications

(46 reference statements)

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“…A total of 13 studies 1 , 6 , 7 , 16 , 19 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 were included in our study (PRISMA flow diagram) based on the searched databases. Overall, eight studies 1 , 6 , 7 , 37 , 39 , 40 , 41 , 43 focused on the role of RDW and the remaining five studies 16 , 19 , 36 , 38 , 42 focused on D‐Dimer levels in DLBCL patients.…”

Section: Resultsmentioning

confidence: 99%

“…All included articles were retrospective cohorts. Eight studies were conducted in China 7 , 16 , 19 , 36 , 38 , 39 , 40 , 43 and others were conducted in Croatia, 41 Iraq, 37 Japan, 42 Peru, 1 and Spain. 6 The total sample size of the meta‐analysis was 3972 people (1252 and 2720 patients in the studies were related to prognostic roles of D‐Dimer and RDW in DLBCL patients, respectively) varying from 81 to 992 people in the included studies.…”

Section: Resultsmentioning

confidence: 99%

“…The pooled analysis presented a significant association between increased RDW and adverse OS of the patients (HR Pooled = 2.01, 95% CI: 1.62–2.48, p value <.01) (Table 1 ) (Figure 2 ). Examining the correlation between the D‐Dimer and OS among the patients with DLBCL was performed by four studies 16 , 19 , 38 , 42 with 1066 patients and D‐Dimer levels correlated with poorer OS. The combined results also demonstrated that increased D‐Dimer was associated with worse OS of the patients (HR Pooled = 2.30, 95% CI: 1.03–5.14, p value <.05) (Figure 3 ).…”

Section: Resultsmentioning

confidence: 99%

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Prognostic value of red blood cell distribution width and D‐Dimer in diffuse large B‐cell lymphoma: Systematic review and meta‐analysis

Rahchamani,

Sedghi,

Hakimi

et al. 2023

Cancer Reports

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BackgroundThe significant role of red blood cell distribution width (RDW) and D‐Dimer as prognostic factors in patients with some blood malignancies has been reported recently.AimWe designed and performed a meta‐analysis to investigate the prognostic roles of RDW and D‐Dimer in subjects with diffuse large B‐cell lymphoma (DLBCL).Materials and MethodsWe systematically reviewed PubMed‐Medline, SCOPUS, EMBASE, Web of Science Core Collection, and Google Scholar up to the present to look for publications on prognostic effects of RDW and D‐Dimer in DLBCL patients. For investigation of the associations between RDW and D‐Dimer with the overall survival (OS) and progression‐free survival (PFS) of the DLBCL cases, hazard ratio (HR) with 95% confidence intervals (CIs) was used.ResultsWe included 13 eligible studies in the present meta‐analysis. The results of pooled analysis showed that increased levels of RDW was related to poor OS (HR = 2.01, 95% CI: 1.62–2.48, p value <.01, I2 = 0%) and poor PFS (HR = 1.52, 95% CI: 1.24–1.85, p value <.01, I2 = 16%) among the DLBCL patients. Similarly, a significant relationship was found between increased D‐Dimer and poor OS (HR = 2.30, 95% CI: 1.03–5.14, p value <.05, I2 = 95%) of the DLBCL patients as well. In addition, there was no significant heterogeneity in OS (p value H = 0.65) and PFS (p value H = 0.31) related to RDW among studies included in the meta‐analysis.ConclusionOur finding clearly confirmed that elevated RDW levels and D‐Dimer were associated with adverse OS and PFS in DLBCL.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Prognostic value of red blood cell distribution width and D‐Dimer in diffuse large B‐cell lymphoma: Systematic review and meta‐analysis

Rahchamani,

Sedghi,

Hakimi

et al. 2023

Cancer Reports

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show abstract

“…A total of 13 studies (1,6,7,16,19,(36)(37)(38)(39)(40)(41)(42)(43) were included in our study (PRISMA flow diagram) based on the searched databases. Overall, eight studies (1,6,7,37,(39)(40)(41)43) focused on the role of RDW and the remaining five studies (16,19,36,38,42) focused on D-Dimer levels in DLBCL patients. The included studies were published from 2015 to 2022.…”

Section: Resultsmentioning

confidence: 99%

Prognostic Value of Red Blood Cell Distribution Width and D-Dimer in Diffuse Large B-cell Lymphoma: Systematic Review and Meta-analysis.

Rahchamani,

Sedghi,

Hakimi

et al. 2023

Preprint

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Background: The significant role of red blood cell distribution width (RDW) and D-Dimer as prognostic factors in patients with some blood malignancies has been reported recently. Aim: We designed and performed a meta-analysis to investigate the prognostic roles of RDW and D-Dimer in subjects with diffuse large B-cell lymphoma (DLBCL). Materials and Methods: We systematically reviewed PubMed-Medline, SCOPUS, EMBASE, Web of Science Core Collection, and Google Scholar up to 30 April 2023 to look for publications on prognostic effects of RDW and D-Dimer in DLBCL patients. For investigation of the associations between RDW and D-Dimer with the overall survival (OS) and progression-free survival (PFS) of the DLBCL cases, hazard ratio (HR) with 95% confidence intervals (CIs) was used. Results: We included 13 eligible studies in the present meta-analysis. The results of pooled analysis showed that increased levels of RDW was related to poor OS (HR=2.01, 95% CI: 1.62-2.48, P value<0.01) and poor PFS (HR=1.52, 95% CI: 1.24-1.85, P value<0.01) among the DLBCL patients. On the other hand, a significant relationship was found between increased D-Dimer and poor OS (HR=2.30, 95% CI: 1.03-5.14, P value<0.05) of the DLBCL patients as well. Conclusion: Our finding clearly confirmed that elevated RDW levels and D-Dimer were associated with adverse OS and PFS in DLBCL.

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“…As a degradation product of fibrin, elevated D-dimer could reflect high activation of coagulation and fibrinolysis, which was supposed to be related with poor OS of DLBCL. 10,11 Furthermore, CRP is one of the standard markers that reflect objective inflammation 12 and it has shown that elevated CRP has a negative prognostic impact on DLBCL. 13 Inadequate diet and proliferation of tumor cells have contributed to malnutrition in cancer patients, which in turn leads to poor response to treatment.…”

Section: Introductionmentioning

confidence: 99%

A Novel Inflammatory-Nutritional Prognostic Scoring System for Patients with Diffuse Large B Cell Lymphoma

Wang,

Bao,

et al. 2024

JIR

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Purpose This study aimed to examine the predictive ability of inflammatory and nutritional markers and further establish a novel inflammatory nutritional prognostic scoring (INPS) system. Patients and Methods We collected clinicopathological and baseline laboratory data of 352 patients with DLBCL between April 2010 and January 2023 at the First affiliated hospital of Ningbo University. Eligible patients were randomly divided into training and validation cohorts (n = 281 and 71, respectively) in an 8:2 ratio. We used the least absolute shrinkage and selection operator (LASSO) Cox regression model to determine the most important factors among the eight inflammatory-nutritional variables. The impact of INPS on OS was evaluated using the Kaplan–Meier curve and the Log rank test. A prognostic nomogram was developed based on the multivariate Cox regression method. Then, we used the concordance index (C-index), calibration plot, and time-dependent receiver operating characteristic (ROC) analysis to evaluate the prognostic performance and predictive accuracy of the nomogram. Results Seven inflammatory-nutritional biomarkers, including neutrophil-lymphocyte ratio (NLR), prognostic nutritional index (PNI), body mass index (BMI), monocyte-lymphocyte ratio (MLR), prealbumin, C reactive protein, and D-dimer were selected using the LASSO Cox analysis to construct INPS, In the multivariate analysis, IPI-High-intermediate group, IPI-High group, high INPS were independently associated with OS, respectively. The prognostic nomogram for overall survival consisting of the above two indicators showed excellent discrimination. The C-index for the nomogram was 0.94 and 0.95 in the training and validation cohorts. The time-dependent ROC curves showed that the predictive accuracy of the nomogram for OS was better than that of the NCCN-IPI system. Conclusion The INPS based on seven inflammatory-nutritional indexes was a reliable and convenient predictor of outcomes in DLBCL patients.

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High pretreatment plasma D-dimer levels predict poor survival in patients with diffuse large B-cell lymphoma in the real world

Abstract: Background: Data on the role of pretreatment plasma D-dimer levels in the prognostic prediction of patients with diffuse large B-cell lymphoma (DLBCL) are limited. We here studied the potential prognostic roles of pretreatment plasma D-dimer levels in patients with DLBCL.

Cited by 4 publications

References 30 publications

Prognostic value of red blood cell distribution width and D‐Dimer in diffuse large B‐cell lymphoma: Systematic review and meta‐analysis

Prognostic value of red blood cell distribution width and D‐Dimer in diffuse large B‐cell lymphoma: Systematic review and meta‐analysis

Prognostic Value of Red Blood Cell Distribution Width and D-Dimer in Diffuse Large B-cell Lymphoma: Systematic Review and Meta-analysis.

A Novel Inflammatory-Nutritional Prognostic Scoring System for Patients with Diffuse Large B Cell Lymphoma

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